2015
DOI: 10.1210/jc.2015-1392
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Abnormal Skeletal Strength and Microarchitecture in Women With Celiac Disease

Abstract: Women with CD had abnormal vBMD and microarchitecture at both the radius and tibia. Trabecular bone was preferentially affected. These deficits were associated with lower estimates of skeletal strength. These findings suggest a potential structural mechanism for skeletal fragility in CD and support further research into the pathogenesis of fracture in this population.

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Cited by 22 publications
(25 citation statements)
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“…Lower BMD than expected also affects about half of patients with subclinical CD, who have mild symptoms and often remain undiagnosed [3]. In addition to low BMD, the bone microarchitecture may be deteriorated [4,5] making CD patients more susceptible to low energy fractures. Evidence of increased fracture risk in CD patients is however not consistent [6] and the need for BMD screening is debated.…”
Section: Introductionmentioning
confidence: 99%
“…Lower BMD than expected also affects about half of patients with subclinical CD, who have mild symptoms and often remain undiagnosed [3]. In addition to low BMD, the bone microarchitecture may be deteriorated [4,5] making CD patients more susceptible to low energy fractures. Evidence of increased fracture risk in CD patients is however not consistent [6] and the need for BMD screening is debated.…”
Section: Introductionmentioning
confidence: 99%
“…When making a diagnosis of CD, it is very important to know if the patient suffers from the different symptoms; since studies that diagnose CD are invasive analyses [4,5,9,10,20,22,24,26,27,[30][31][32]37,39,41,43,45,46,[49][50][51]58]. Therefore, before requesting the analyses, it is useful to perform a Celiac Symptom Index test to identify the symptoms apart from the clear use of the clinical history; in this way, a better diagnosis can be made [57].…”
Section: Discussionmentioning
confidence: 99%
“…Another of the least performed studies for the diagnosis of CD is the immunoassay metric [40]; in this, the level of antigens and antibodies is measured and they use the serum endomysia antibody [1,19,20,22,33,35,37]. Different articles present that sensitivity to gluten or development of CD were related to a genetic factor.…”
Section: Characteristic Of the Included Studiesmentioning
confidence: 99%
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“…Other factors include chronic inflammation, with increased cytokine levels that interfere with bone growth and autoimmune factors . Skeletal fragility, as measured by microarchitecture by high‐resolution computed tomography, is also diminished in individuals with newly diagnosed CD . Improvement of bone density often occurs after institution of the gluten‐free diet, though the improvement can be modest …”
Section: Discussionmentioning
confidence: 99%