Resolution of Crohn's disease and complex regional pain syndrome following treatment of paratuberculosis

Abstract

A cohort of family members with various chronic diseases including Crohn's disease, asthma, complex regional pain syndrome, hypothyroidism, type 1 diabetes mellitus, and lymphangiomatosis and/or evidence of infection by Mycobacterium avium subsp. paratuberculosis (MAP) are described in this series of case reports. MAP was cultured from the blood of three members affected by the first five diseases and there was accompanying elevated anti-MAP IgG in two members. The patient affected by the sixth disease has a markedly elevated anti-MAP titer. The two patients affected by the first four diseases have been treated with a combination of anti-MAP antibiotics and ultraviolet blood irradiation therapy with resolution of the disease symptomatology and inability to culture MAP in post treatment blood samples. These case reports of patients with MAP infections provide supportive evidence of a pathogenic role of MAP in humans.

Concurrent Resolution of Chronic Diarrhea Likely Due to Crohn’s Disease and Infection with Mycobacterium avium paratuberculosis

“…This case provides additional evidence, supporting studies showing MAP is the causative agent in, at least, a subset of patients with CD (26) and that antibiotic therapy may lead to a cure of CD and clearance of infection with MAP . The results are consistent with findings from a group of MAP infected patients treated successfully by one of the coauthors, Dr. J. Todd Kuenstner, in the United States using a regimen of multi-antibiotic therapy combined with ultraviolet blood irradiation (UVBI) (27, 28). Of major importance, the results obtained in this report and the mass survey in India emphasize the need for recognition, at the international level, that MAP is a zoonotic pathogen and that it is a health risk for humans and livestock (29).…”

Dental management of lymphangiomatosis: case report

“…Bone‐specific alkaline phosphatase (BAP), serum C‐terminal telopeptide‐1, tartrate‐resistant acid phosphatase and serum interleukin‐6 have also been reported as potential biomarkers. There is evidence suggesting that infection with Mycobacterium avium paratuberculosis may have a pathogenic link to lymphangiomatosis, warranting further investigation into potential infectious sources of this disease.…”

Resolution of Crohn’s (Johne’s) disease with antibiotics: what are the next steps?

“…Their disease was resolved by the therapy, and Map could no longer be cultured from their blood. One of the patients was treated with a combination of antibiotics alone [13], and the other two patients were treated with a combination of antibiotics and ultraviolet blood irradiation [14,15].…”

“…Patients could have other diseases and present with variations of the symptoms generally associated with CD [10,14,[19][20][21][22]. In some cases, evidence of infection would not be apparent because another concurrent disease might overshadow infection with Map.…”