2583 Expression of the cell cycle regulator p27 kip1 in Saudi bladder cancer patients

The role of p27 as a prognostic factor in association with grading and staging of urothelial bladder cancer

“…Regarding tumor grade, 56.6% of the cases were high-grade UC. There was no significant statistical correlation between p27 expression and tumor grade, which contrasts with other studies where a significant correlation was noted [7,8] . This study found an inverse relationship between low p27 expression and high-grade tumors, similar to findings in other populations [9] .…”

“…The expression of p27 was found in 41.5% of the cases, aligning with findings from similar studies, where p27 expression varied between 43.3% to 83.4% in UC cases. These variations could be attributed to differences in the type of specimens (e.g., recurrent or progressing UCs) and sample sizes [4,[7][8][9] . Age distribution in the study ranged from 36 to 92 years, with a mean of 62.70±11.44 years, predominantly in the sixth decade.…”

“…Stages 0 and 1, considered superficial bladder cancers, showed higher p27 positivity compared to stages 2, 3, and 4, which are considered deeper invasions. This significant association between p27 expression and earlystage tumors suggests its potential as a prognostic marker for less aggressive disease stages [7][8][9]13] . The muscle invasion status of bladder cancer revealed that non-muscle invasive bladder tumors (NMIBT) had a higher p27 expression score compared to muscle invasive bladder tumors (MIBT), although the difference was not statistically significant in this study.…”