2015
DOI: 10.1371/journal.pone.0120939
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Comprehensive Comparison of Three Different Immunosuppressive Regimens for Liver Transplant Patients with Hepatocellular Carcinoma: Steroid-Free Immunosuppression, Induction Immunosuppression and Standard Immunosuppression

Abstract: The different choices of immunosuppression (IS) regimens influenced the outcomes of liver transplantation. Steroid was applied as a standard IS to prevent and treat rejections. However, steroid-related complications were increasingly prominent. This study compared the efficacy and safety of standard IS regimens with the efficacy and safety of steroid-free IS regimen and induction IS regimen in Chinese liver transplantation recipients for hepatocellular carcinoma (HCC). A total of 329 patients who underwent liv… Show more

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Cited by 13 publications
(8 citation statements)
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“… 3 Moreover, the choice of an appropriate immunosuppressive treatment protocol is of great importance. 4 6 Consideration should be given to protocols with low levels of adverse effects, so that approaches would largely translate into the quality of life of patients.…”
Section: Introductionmentioning
confidence: 99%
“… 3 Moreover, the choice of an appropriate immunosuppressive treatment protocol is of great importance. 4 6 Consideration should be given to protocols with low levels of adverse effects, so that approaches would largely translate into the quality of life of patients.…”
Section: Introductionmentioning
confidence: 99%
“…For immunosuppressive protocol, we used the standard three-drug regimen including steroid, tacrolimus/cyclosporine, and mycophenolate mofetil (MMF). For recipients with hepatocellular carcinoma (HCC), steroid-free protocol was applied as described by Shen et al[ 8 ].…”
Section: Methodsmentioning
confidence: 99%
“…Das mögliche Ausschleichen (▶ Tab. 4) und Absetzen von Kortison wurde in mehreren Studien untersucht und aufgearbeitet [28,29]. Die Therapie der akuten Abstoßung wird in Form einer hochdosierten Kortisongabe (500-1000 mg) über 3- Erhaltungstherapie Merke Der Goldstandard der Erhaltungstherapie nach NTx, der auch in den Leitlinien [32] empfohlen ist, besteht aus einer Kombination von CyA oder TAC, MMF und Steroiden.…”
Section: De-novo-therapieunclassified