Enterovirus A71 Subgenotype B5, France, 2013

Mirand, Audrey; Molet, Lucie; Hassel, Chervin; Peigue-Lafeuille, Ha C lA Ne; Rozenberg, Flore; Bailly, Jean‐Luc; Henquell, C

doi:10.3201/eid2104.141093

Cited by 10 publications

(9 citation statements)

References 9 publications

(14 reference statements)

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“…The recent reporting of sporadic circulation of EV-71 strains of the 'Asian subgenogroups' B5 [30,31] and C4 [32][33][34] in European countries makes it important to determine the evolutionary origins and spatiotemporal spread of EV-71 infections in geographical areas other than eastern and south-east Asia. There is a large body of literature on the molecular epidemiology of EV-71 [35] but, to our knowledge, the spread of this virus has not yet been analysed explicitly with recently developed phylogeographical models [26].…”

Section: Discussionmentioning

confidence: 99%

“…The introduction events in Russia are shown with full triangles. The introduction events of the EV-71 subgenogroup B5 in Denmark [30] and France [31] are shown with diamonds. The 1D VP1 sequences were determined in the virus isolates with the previously described genotyping methods [12,22].…”

Section: Figurementioning

confidence: 99%

“…The population size of both C1 and C2 subgenogroups remained low over the years 2004 to 2006 and 2008 to 2013, periods during which the EV-71/C4 subgenogroup occurred in several European countries (Austria, Croatia, France, Germany, and Hungary) and Canada (see below). EV-71/B5 caused an outbreak in Denmark (2007) [30] and a sporadic infection in France (2013) [31].…”

Section: Genealogy-based Population Dynamics Of Enterovirus 71 Subgenmentioning

confidence: 99%

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Transmission patterns of human enterovirus 71 to, from and among European countries, 2003 to 2013

et al. 2015

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Enterovirus 71 (EV-71) is involved in epidemics of hand, foot, and mouth disease (HFMD) and has been reported to occur with severe neurological complications in eastern and south-east Asia. In other geographical areas, the transmission of this virus is poorly understood. We used large sequence datasets (of the gene encoding the viral protein 1, VP1) and a Bayesian phylogenetic approach to compare the molecular epidemiology and geographical spread patterns of EV-71 subgenogroups B4, B5, C1, C2, and C4 in Europe relative to other parts of the world. For the study, European countries considered were European Union (EU) Member States and Iceland, Norway and Switzerland. Viruses of the B4, B5, and C4 subgenogroups circulate mainly in eastern and south-east Asia. In Europe sporadic introductions of these subgenogroups are observed, however C1 and C2 viruses predominate. The phylogenies showed evidence of multiple events of spread involving C1 and C2 viruses within Europe since the mid-1990s. Two waves of sporadic C2 infections also occurred in 2010 and 2013. The 2007 Dutch outbreak caused by C2 and the occurrence of B5 and C4 infections in the EU between 2004 and 2013 arose while the circulation of C1 viruses was low. A transmission chain involving a C4 virus was traced from Japan to the EU and then further to Canada between 2001 and 2006. Recent events whereby spread of viruses have occurred from, to, and within Europe appear to be involved in the long term survival of EV-71, highlighting the need for enhanced surveillance of this virus.

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Section: Discussionmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Section: Genealogy-based Population Dynamics Of Enterovirus 71 Subgenmentioning

confidence: 99%

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Transmission patterns of human enterovirus 71 to, from and among European countries, 2003 to 2013

et al. 2015

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“…Additionally, we showed neutralization of the C4 strain by a polyclonal rabbit serum against EV-71 C1, which confirms that nAbs elicited against C1 are cross-protective against C4. We did not have access to antigenically divergent genotype B5 strains, which is unfortunate, as B5 strains were isolated from clinical specimens in Denmark in 2007 and in France in 2013 ( 8 ).…”

Section: Discussionmentioning

confidence: 99%

Prediction of Protection against Asian Enterovirus 71 Outbreak Strains by Cross-neutralizing Capacity of Serum from Dutch Donors, The Netherlands

Sanden¹,

Koen²,

Eijk³

et al. 2016

Emerg. Infect. Dis.

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“…The B5 subgenotype, which was detected several years after the discovery of C4, is also considered to be a predominant genotype circulating in a manner similar to that of the C4 subgenotype (Huang et al, 2008 ; Mirand et al, 2015 ). It was first described in an outbreak that occurred in Sarawak, Malaysia (Podin et al, 2006 ).…”

Section: Introductionmentioning

confidence: 99%

Global Spread of the B5 Subgenotype EV-A71 and the Phylogeographical Analysis of Chinese Migration Events

Huang¹,

Zhang

Han³

et al. 2020

Front. Cell. Infect. Microbiol.

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The subgenotype B5 of EV-A71 is a widely circulating subgenotype that frequently spreads across the globe. Several outbreaks have occurred in nations, such as Malaysia, Thailand, Vietnam, and Japan. Appearing first in Taiwan, China, the subgenotype has been frequently reported in mainland of China even though no outbreaks have been reported so far. The current study reconstructed the migration of the B5 subgenotype of EV-A71 in China via phylogeographical analysis. Furthermore, we investigated its population dynamics in order to draw more credible inferences. Following a dataset cleanup of B5 subgenotype of EV-A71, we detected earlier B5 subgenotypes of EV-A71 sequences that had been circulating in Malaysia and Singapore since the year 2000, which was before the 2003 outbreak that occurred in Sarawak. The Bayesian inference indicated that the most recent common ancestor of B5 subgenotype EV-A71 appeared in September, 1994 (1994.75). With respect to the overall prevalence, geographical reconstruction revealed that the B5 subgenotype EV-A71 originated singly from single-source cluster and subsequently developed several active lineages. Based on a large amount of data that was accumulated, we conclude that the appearance of the B5 subgenotype of EV-A71 in mainland of China was mainly due to multiple migrations from different origins.

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Enterovirus A71 Subgenotype B5, France, 2013

Cited by 10 publications

References 9 publications

Transmission patterns of human enterovirus 71 to, from and among European countries, 2003 to 2013

Transmission patterns of human enterovirus 71 to, from and among European countries, 2003 to 2013

Prediction of Protection against Asian Enterovirus 71 Outbreak Strains by Cross-neutralizing Capacity of Serum from Dutch Donors, The Netherlands

Global Spread of the B5 Subgenotype EV-A71 and the Phylogeographical Analysis of Chinese Migration Events

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