“…The therapeutic effect demonstrated by Z. officinale or omega‐3 is coherent with other studies that evaluated both therapies or their individual components against metabolic syndrome disorders such as type2 diabetes, obesity, IR, and NAFLD. These effects have been studied to be through regulation of lipogenesis, β‐oxidation besides their antioxidant and anti‐inflammatory activity (de Castro, Cardoso, Calder, Jordão, & Vannucchi, ; Huang, Deng, Meng, & Ma, ; Lai et al, ; Li et al, ; Molinar‐Toribio et al, ; Singh, Akanksha, Singh, Maurya, Srivastava, ). Here, we demonstrated a novel pathway by which the therapeutic approaches treat NAFLD by modulation of ER stress proposed to be responsible for NAFLD progression through different mechanisms (Ferré & Foufelle, ; Jo et al, ; Lee et al, ).…”