The Effects of Tryptophan on Everyday Interpersonal Encounters and Social Cognitions in Individuals with a Family History of Depression

Hogenelst, Koen; Schoevers, Robert A.; Rot, Marije aan het

doi:10.1093/ijnp/pyv012

Cited by 7 publications

(6 citation statements)

References 46 publications

(70 reference statements)

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“…Our results could be in agreement with those which found that a family history of depression was associated with poor social functioning . This fact may be due to the existence of subtle impairments in the processing of emotional stimuli . Further longitudinal, genetic studies and research with unaffected relatives are needed to gain a better insight into the trajectories of social cognitive deficits in BD.…”

Section: Discussionsupporting

confidence: 92%

Social cognition in bipolar disorder: the role of sociodemographic, clinical, and neurocognitive variables in emotional intelligence

Varo

Jiménez

Solé

et al. 2019

Acta Psychiatr Scand

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Objective The main aims of this study were to examine the differences in the Emotional Intelligence (EI), the emotional domain of social cognition (SC), between euthymic patients with bipolar disorder (BD) and healthy controls (HC) and to evaluate the contribution of sociodemographic, clinical, and neuropsychological variables to EI. Methods We recruited 202 patients with BD and 50 HC. EI was evaluated using the Mayer–Salovey–Caruso Emotional Intelligence Test (MSCEIT). The sociodemographic, clinical, and neurocognitive variables that showed a significant association with EI were entered into hierarchical multiple regression analysis. Results BD patients obtained significantly lower scores compared to HC in the Emotional Intelligence Quotient (EIQ) and in the Understanding Emotions branch score. The best fitting model for the variables associated with EI in the patients group was a linear combination of gender, estimated IQ, family history of affective diagnosis, and executive function. The model, including these previous variables, explained up to 27.6% of the observed variance (R2 = 0.276, F = 16.406, P < 0.001). Conclusions The identification of variables associated with deficit in EI, such as male gender, lower estimated IQ, family history of affective diagnosis. and lower executive function performance, may help in selecting treatment targets to improve SC, and especially EI, in patients with BD.

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Section: Discussionsupporting

confidence: 92%

Social cognition in bipolar disorder: the role of sociodemographic, clinical, and neurocognitive variables in emotional intelligence

Varo

Jiménez

Solé

et al. 2019

Acta Psychiatr Scand

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“…For example, there is evidence that TRP supplementation can promote prosocial behaviour in economic decision-making tasks ( 22 ) . Somewhat counterintuitively, a more recent study, in which 1 g TRP was given three times daily for 14 d to those with a family history of depression, found increased quarrelsomeness and reduced agreeableness (at home), but improved mood, compared with placebo ( 86 ) . This was interpreted as possibly reflecting the development of more control in social interactions at home.…”

Section: Effects Of L-tryptophan Administration and Supplementationmentioning

confidence: 97%

Tryptophan supplementation and serotonin function: genetic variations in behavioural effects

Gibson

2018

Proc. Nutr. Soc.

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The neurotransmitter serotonin has a role in affective disorders such as depression and anxiety, as well as sleep, cognitive function and appetite. This review examines the evidence that serotonin-related genotypes may moderate the behavioural effects of supplementation with the serotonin precursor amino acid l-tryptophan (TRP), on which synthesis of serotonin (or 5-hydroxytryptamine; 5-HT) depends. However, 95 % of serotonin is synthesised and used in the periphery, and TRP is also metabolised via non-5-HT routes such as the kynurenine pathway. Moreover, understanding of genotypes involved in regulation of serotonin raises questions over the generalisability of TRP effects on behaviour across individuals with varied serotonergic genotypes. To date, only differences between variants of the 5-HT transporter-linked promoter region (5-HTTLPR) have been investigated in relation to behavioural effects of TRP supplementation. Effects of 5-HTTLPR genotypes are usually compared between the alleles that are either high (L/L') or low (S/S') expressing of mRNA for the 5-HT transporter receptor. Yet, another key genetic variable is sex: in women, the S/S' genotype predicts sensitivity to improved mood and reduced cortisol by TRP supplementation, during stressful challenges, whereas the L/L' genotype protects against stress-induced mood deterioration. In men, the L/L' genotype may confer risk of stress-induced increases in negative affect; there are insufficient data to assess effects on male S/S' genotypes. However, better-powered studies to detect sex by genotype by stress by TRP interactions, as well as consideration of more genotypes, are needed before strong conclusions and recommendations for behavioural effects of TRP treatment can be reached.

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“…This study is part of a more comprehensive project assessing the role of serotonin in social behaviour; an overview of all included measures can be found at Clinical Trials.gov (NCT020051530). Eleven FH+ individuals also participated in a related project (Hogenelst et al, 2015; NCT02051569).…”

Section: Methodsmentioning

confidence: 99%

The effects of acute tryptophan depletion on speech and behavioural mimicry in individuals at familial risk for depression

et al. 2016

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Major depressive disorder (MDD) has been associated with abnormalities in speech and behavioural mimicry. These abnormalities may contribute to the impairments in interpersonal functioning that are often seen in MDD patients. MDD has also been associated with disturbances in the brain serotonin system, but the extent to which serotonin regulates speech and behavioural mimicry remains unclear. In a randomized, double-blind, crossover study, we induced acute tryptophan depletion (ATD) in individuals with or without a family history of MDD. Five hours afterwards, participants engaged in two behavioural-mimicry experiments in which speech and behaviour were recorded. ATD reduced the time participants waited before speaking, which might indicate increased impulsivity. However, ATD did not significantly alter speech otherwise, nor did it affect mimicry. This suggests that a brief lowering of brain serotonin has limited effects on verbal and non-verbal social behaviour. The null findings may be due to low test sensitivity, but they otherwise suggest that low serotonin has little effect on social interaction quality in never-depressed individuals. It remains possible that recovered MDD patients are more strongly affected.

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The Effects of Tryptophan on Everyday Interpersonal Encounters and Social Cognitions in Individuals with a Family History of Depression

Cited by 7 publications

References 46 publications

Social cognition in bipolar disorder: the role of sociodemographic, clinical, and neurocognitive variables in emotional intelligence

Social cognition in bipolar disorder: the role of sociodemographic, clinical, and neurocognitive variables in emotional intelligence

Tryptophan supplementation and serotonin function: genetic variations in behavioural effects

The effects of acute tryptophan depletion on speech and behavioural mimicry in individuals at familial risk for depression

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