Switch to mania after ayahuasca consumption in a man with bipolar disorder: a case report

Szmulewicz, Alejandro G.; Valerio, Marina P; Smith, José

doi:10.1186/s40345-014-0020-y

Cited by 37 publications

(37 citation statements)

References 12 publications

(12 reference statements)

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“…Ayahuasca may be contraindicated for bipolar disorders patients, since a recent case report described a man with bipolar disorder that developed a manic episode after ayahuasca consumption. 12 Increased blood perfusion in the subgenual area, nucleus accumbens, and insula were observed after ayahuasca intake. Hypoactivation of these brain regions is usually associated with depression, while increased activation is usually associated with antidepressive effects.…”

Section: Discussionmentioning

confidence: 98%

Antidepressant Effects of a Single Dose of Ayahuasca in Patients With Recurrent Depression

Sanches¹,

Osório²,

Santos³

et al. 2016

Journal of Clinical Psychopharmacology

402

434

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Ayahuasca is an Amazonian botanical hallucinogenic brew which contains dimethyltryptamine, a 5-HT2A receptor agonist, and harmine, a monoamine-oxidase A inhibitor. Our group recently reported that ayahuasca administration was associated with fast-acting antidepressive effects in 6 depressive patients. The objective of the present work was to assess the antidepressive potentials of ayahuasca in a bigger sample and to investigate its effects on regional cerebral blood flow. In an open-label trial conducted in an inpatient psychiatric unit, 17 patients with recurrent depression received an oral dose of ayahuasca (2.2 mL/kg) and were evaluated with the Hamilton Rating Scale for Depression, the Montgomery-Åsberg Depression Rating Scale, the Brief Psychiatric Rating Scale, the Young Mania Rating Scale, and the Clinician Administered Dissociative States Scale during acute ayahuasca effects and 1, 7, 14, and 21 days after drug intake. Blood perfusion was assessed eight hours after drug administration by means of single photon emission tomography. Ayahuasca administration was associated with increased psychoactivity (Clinician Administered Dissociative States Scale) and significant score decreases in depression-related scales (Hamilton Rating Scale for Depression, Montgomery-Åsberg Depression Rating Scale, Brief Psychiatric Rating Scale) from 80 minutes to day 21. Increased blood perfusion in the left nucleus accumbens, right insula and left subgenual area, brain regions implicated in the regulation of mood and emotions, were observed after ayahuasca intake. Ayahuasca was well tolerated. Vomiting was the only adverse effect recorded, being reported by 47% of the volunteers. Our results suggest that ayahuasca may have fast-acting and sustained antidepressive properties. These results should be replicated in randomized, double-blind, placebo-controlled trials.

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Section: Discussionmentioning

confidence: 98%

Antidepressant Effects of a Single Dose of Ayahuasca in Patients With Recurrent Depression

Sanches¹,

Osório²,

Santos³

et al. 2016

Journal of Clinical Psychopharmacology

402

434

View full text Add to dashboard Cite

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“…[94] also suggested that recreational DMT use could be a contributor to psychosis. Another case report discussed a man with preexisting bipolar disorder who had a manic episode following ayahuasca consumption [95].…”

Section: Physiologic Effects Safety and Adverse Effectsmentioning

confidence: 99%

Ayahuasca: Psychological and Physiologic Effects, Pharmacology and Potential Uses in Addiction and Mental Illness

et al. 2019

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Many years of shamanic wisdom have indicated potential therapeutic uses for ayahuasca, and many present day studies suggest that it may be useful for treating various psychiatric disorders and addictions. The side effect profile appears to be relatively mild, but more detailed studies need to be done. Several prominent researchers feel that government regulations with regard to ayahuasca should be relaxed so that it could be provided more readily to recognized credible researchers to conduct comprehensive clinical trials.

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“…Another report associated an individual with polar disorders, that presented a manic episode after in a 4-day ingested ayahuasca, without any caution [155]. Also, intoxication by β-carboline alkaloids in a P. harmala seeds infusion was reported [156].…”

Section: Cases Of Intoxication Associated With the Ingestion Of Ayahumentioning

confidence: 99%

Ayahuasca: Uses, Phytochemical and Biological Activities

Estrella-Parra

Almanza-Perez

Alarcón-Aguilar

2019

Nat. Prod. Bioprospect.

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Ayahuasca (caapi, yajé), is a psychoactive brew from the Amazon Basin region of South America traditionally considered a "master plant." It is prepared as a decoction from Banisteriopsis caapi and Psychotria viridis, which it is thought that it stimulates creative thinking and visual creativity. Native healers of the Orinoco and Amazon basins have used traditionally ayahuasca as a healing tool for multiple purposes, particularly to treat psychological disorders in the patients, with some beneficial effects experimentally and clinically validated. Recently, several syncretic religions, as the "União de Vegetal" (UDV) group in Brazil, have been spread around the world. The use of ayahuasca has been popularized by internet and smart-shops, bringing the psychoactive substance to new highs, emerging new "ayahuasqueros." Ayahuasca has alkaloids as β-carbolines and dimethyltryptamines, which inhibit the monoamine oxidase and active the 5-HT 2A (5-hydroxytryptamine) receptor, respectively, resulting in hallucinations in the users. Ayahuasca induces a psychedelic change in the anteroposterior coupling of the electrophysiological brain oscillations in humans. Traditional ayahuasca beverage is generating pharmacological, commercial and spiritual interest among the scientific community, government people, and different populations worldwide. The goal of this article is to report about the uses, chemistry and biological activities of ayahuasca.

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Switch to mania after ayahuasca consumption in a man with bipolar disorder: a case report

Cited by 37 publications

References 12 publications

Antidepressant Effects of a Single Dose of Ayahuasca in Patients With Recurrent Depression

Antidepressant Effects of a Single Dose of Ayahuasca in Patients With Recurrent Depression

Ayahuasca: Psychological and Physiologic Effects, Pharmacology and Potential Uses in Addiction and Mental Illness

Ayahuasca: Uses, Phytochemical and Biological Activities

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