Review Selenium as a marker of cancer risk and of selection for control examinations in surveillance

Lener, Marcin; Muszyńska, Magdalena; Jakubowska, Anna; Jaworska–Bieniek, Katarzyna; Sukiennicki, Grzegorz; Kaczmarek, Katarzyna; Durda, Katarzyna; Gromowski, Tomasz; Serrano-Fernández, Pablo; Kładny, Józef; Wiechowska–Kozłowska, Anna; Grodzki, Tomasz; Jaworowska, Ewa; Lubiński, J; Górecka-Szyld, Barbara; Wilk, Grażyna; Huzarski, Tomasz; Byrski, Tomasz; Cybulski, Cezary; Gronwald, Jacek; Dębniak, Tadeusz; Ashuryk, Olgierd; Tołoczko‐Grabarek, Aleksandra; Morawski, Antoni W.; Scott, Rodney J.; Lubiński, Jan

doi:10.5114/wo.2014.47131

Cited by 5 publications

(6 citation statements)

References 5 publications

(4 reference statements)

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“…Geographical differences can cause discrepancies. The average Se level in North America is 122.4–151.8 μg/L, while the level in the serum / plasma of Poles is about 70 μg/L; in some regions, it is even 50–55 μg/L [2,32,33,34]. In our control (normotensive group), the mean Se level in the serum in the 10–14th pregnancy week was 62.89 μg/L (range 41.14–125.54 µg/L).…”

Section: Discussionmentioning

confidence: 99%

Serum Selenium Level in Early Healthy Pregnancy as a Risk Marker of Pregnancy Induced Hypertension

Lewandowska

Sajdak²,

Lubiński³

2019

Nutrients

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Selenium (Se) is an antioxidant nutrient whose deficiency can influence adverse outcomes of pregnancy. The aim of this study is to determine whether serum Se level in early healthy pregnancy may be a risk marker for pregnancy induced hypertension. We obtained data from our prospective study in which we recruited healthy women in weeks 10–14 of a single pregnancy. In this analysis, we examined 121 women who subsequently developed pregnancy-induced hypertension and matched 363 women who remained normotensive. We measured Se levels (using the ICP-MS technique) in the serum in weeks 10–14 of the pregnancy. The odds ratios of pregnancy-induced hypertension (95% confidence intervals) were calculated using multivariate logistic regression. We found that the mean Se level was lower in the case group compared to the control (57.51 vs. 62.89 μg/L; p = 2.6 × 10−10). Excessive body mass index (BMI) and smoking influenced the estimated odds ratios. In the subgroup of women who had never smoked with normal pre-pregnancy BMI, the adjusted odds ratio (AOR) of pregnancy-induced hypertension was 15.34 (95% CI: 2.73–86.31, p = 0.002) for Se levels in the lowest quartile (≤57.68 µg/L), as compared to the highest quartile (>66.60 µg/L), after adjusting for all the accepted confounders. In the whole cohort, the prognostic value of Se by logistic regression showed that the area under curve (AUC) = 0.814. In our study, one can consider the role of Se as a risk marker of pregnancy-induced hypertension.

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Section: Discussionmentioning

confidence: 99%

Serum Selenium Level in Early Healthy Pregnancy as a Risk Marker of Pregnancy Induced Hypertension

Lewandowska

Sajdak²,

Lubiński³

2019

Nutrients

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“…In many research papers devoted to the study of the mechanisms of endogenous neuroprotection under conditions of ischemia, the resumption of the work of the glutathione unit of the thiol-disulfide system (TDS) during an increase in the level of HSP70 is noted, and the administration of exogenous HSP70 leads to an increase in the functional activity of the glutathione system in ischemic neurons of experimental animals ( Hacke et al, 2008 ). Thus, under conditions of ischemia, HSP70 proteins mobilize antioxidant resources in neurons by increasing the level of both the cytosolic and mitochondrial pool of reduced glutathione ( Lener et al, 2015 ). Recently, data have appeared on the role of HSP in the stabilization of HIF-1a, which, under conditions of ischemia, is responsible for ensuring the processes of proliferation, apoptosis, angiogenesis, and stabilization of protein molecules under conditions of oxidative stress.…”

Section: The Role Of Hsp70 Proteins In the Mechanisms Of Endogenous N...mentioning

confidence: 99%

“…A number of research papers determine the effectiveness of sodium selenite in myocardial infarction. Selenium compounds have an immunomodulating, radioprotective effect due to the function of glutathione peroxidase, which provides the recovery of hydroperoxides and other products of free radical reactions and regulates the release of lipoxygenase and cyclooxygenase metabolites of arachidonic acid ( Koszta et al, 2012 ; Costa et al, 2014 ; Lener et al, 2015 ; Okuyama et al, 2015 ).…”

Section: Possible Pathways For Activation Of Hsp70-dependent Mechanis...mentioning

confidence: 99%

Involvement of heat shock proteins HSP70 in the mechanisms of endogenous neuroprotection: the prospect of using HSP70 modulators

Беленичев

Aliyeva

Popazova

et al. 2023

Front. Cell. Neurosci.

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This analytical review summarizes literature data and our own research on HSP70-dependent mechanisms of neuroprotection and discusses potential pharmacological agents that can influence HSP70 expression to improve neurological outcomes and effective therapy. The authors formed a systemic concepts of the role of HSP70-dependent mechanisms of endogenous neuroprotection aimed at stopping the formation of mitochondrial dysfunction, activation of apoptosis, desensitization of estrogen receptors, reduction of oxidative and nitrosative stress, prevention of morpho-functional changes in brain cells during cerebral ischemia, and experimentally substantiated new target links for neuroprotection. Heat shock proteins (HSPs) are an evolutionarily integral part of the functioning of all cells acting as intracellular chaperones that support cell proteostasis under normal and various stress conditions (hyperthermia, hypoxia, oxidative stress, radiation, etc.). The greatest curiosity in conditions of ischemic brain damage is the HSP70 protein, as an important component of the endogenous neuroprotection system, which, first of all, performs the function of intracellular chaperones and ensures the processes of folding, holding and transport of synthesized proteins, as well as their degradation, both under normoxic conditions and stress-induced denaturation. A direct neuroprotective effect of HSP70 has been established, which is realized through the regulation the processes of apoptosis and cell necrosis due to a long-term effect on the synthesis of antioxidant enzymes, chaperone activity, and stabilization of active enzymes. An increase in the level of HSP70 leads to the normalization of the glutathione link of the thiol-disulfide system and an increase in the resistance of cells to ischemia. HSP 70 is able to activate and regulate compensatory ATP synthesis pathways during ischemia. It was found that in response to the cerebral ischemia formation, HIF-1a is expressed, which initiates the launch of compensatory mechanisms for energy production. Subsequently, the regulation of these processes switches to HSP70, which “prolongs” the action of HIF-1a, and also independently maintains the expression of mitochondrial NAD-dependent malate dehydrogenase activity, thereby maintaining the activity of the malate-aspartate shuttle mechanism for a long time. During ischemia of organs and tissues, HSP70 performs a protective function, which is realized through increased synthesis of antioxidant enzymes, stabilization of oxidatively damaged macromolecules, and direct anti-apoptotic and mitoprotective action. Such a role of these proteins in cellular reactions during ischemia raises the question of the development of new neuroprotective agents which are able to provide modulation/protection of the genes encoding the synthesis of HSP 70 and HIF-1a proteins. Numerous studies of recent years have noted the important role of HSP70 in the implementation of the mechanisms of metabolic adaptation, neuroplasticity and neuroprotection of brain cells, so the positive modulation of the HSP70 system is a perspective concept of neuroprotection, which can improve the efficiency of the treatment of ischemic-hypoxic brain damage and be the basis for substantiating of the feasibility of using of HSP70 modulators as promising neuroprotectors.

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“…Concentrations above 90 μg/L were associated with a higher risk of cancer, but the changes were not statistically significant [ 5 ]. However, Lenar et al indicated that the risk of developing lung cancer increases with decreasing serum selenium concentrations, taking a concentration of 70 μg/L as the cutoff value [ 6 ]. The authors also pointed out that determining the optimal serum selenium concentration is geographically and populationally variable [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Serum Selenium Concentration as a Potential Diagnostic Marker for Early-Stage Colorectal Cancer: A Comparative Study

Chalcarz,

Grabarek,

de Mezer

et al. 2024

Med Sci Monit

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Background Selenium deficiency is an established risk factor for colorectal cancer. The aim of the present study was to determine selenium levels in blood samples obtained from colorectal cancer patients compared with the levels of this element in the blood of patients who had undergone hernia repair and cholecystectomy. Material/Methods The study group consisted of 49 patients diagnosed with colorectal cancer at our institution. The comparison group consisted of 29 and 26 patients undergoing hernia repair and cholecystectomy, respectively. The histological staging level was evaluated on a 4-grade scale. Serum selenium concentration was quantified by inductively coupled mass spectrometry using methane to reduce polyatomic interference. Results Colorectal cancer patients had significantly lower serum selenium concentration than the comparison patients (67.24±15.55 μg/L vs 78.81±12.93 μg/L; P <0.001), and selenium concentration was below the reference range in a high percentage of colorectal cancer patients. However, among the colorectal cancer patients, no significant difference in cancer grading was observed according to selenium concentration ( P =0.235). Serum selenium concentration in the patients was evaluated on the basis of 5 independent variables (R=0.6250): age ( P =0.011), number of leukocytes ( P =0.010), family history of cancer ( P =0.045), dietary supplements ( P =0.023), and exposure to chemical factors ( P =0.057). Conclusions This study supports findings from previous studies that low serum selenium levels are associated with colorectal cancer and that selenium deficiency may be a risk factor for colorectal cancer.

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Review Selenium as a marker of cancer risk and of selection for control examinations in surveillance

Abstract: Publication is summarization of existing data being results of literature review and our experience on usefulness of selenium as a diagnostic marker selection for control examinations in surveillance and as a marker of patients with high risk of cancers.

Cited by 5 publications

References 5 publications

Serum Selenium Level in Early Healthy Pregnancy as a Risk Marker of Pregnancy Induced Hypertension

Serum Selenium Level in Early Healthy Pregnancy as a Risk Marker of Pregnancy Induced Hypertension

Involvement of heat shock proteins HSP70 in the mechanisms of endogenous neuroprotection: the prospect of using HSP70 modulators

Serum Selenium Concentration as a Potential Diagnostic Marker for Early-Stage Colorectal Cancer: A Comparative Study

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