Fibroblast Growth Factors Stimulate Hair Growth through<i>β</i>-Catenin and Shh Expression in C57BL/6 Mice

Platelet-rich plasma (PRP) is currently used in different medical fields. The interest in the application of PRP in dermatology has recently increased. It is being used in several different applications as in tissue regeneration, wound healing, scar revision, skin rejuvenating effects, and alopecia. PRP is a biological product defined as a portion of the plasma fraction of autologous blood with a platelet concentration above the baseline. It is obtained from the blood of patients collected before centrifugation. The knowledge of the biology, mechanism of action, and classification of the PRP should help clinicians better understand this new therapy and to easily sort and interpret the data available in the literature regarding PRP. In this review, we try to provide useful information for a better understanding of what should and should not be treated with PRP.

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“…Various cytokines and GFs are involved in the regulation of hair morphogenesis and cycle hair growth [29]. …”

Section: Mechanism Of Action In Alopeciamentioning

confidence: 99%

A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification

Alves

Grimalt

2017

Skin Appendage Disord

496

416

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“…Therefore, more proliferating keratinocytes were observed in 6-OHDA-treated mice 9 days after depilation. Keratinocytes secrete many different growth factors, such as neurotrophin, fibroblast growth factor (FGF)-1, FGF-2, FGF-10, keratinocyte growth factor, and platelet-derived growth factor, all of which have been shown to promote hair growth [Guo et al, 1996;Grewe et al, 2000;Botchkarev et al, 2006;Barrientos et al, 2008;Lin et al, 2015]. We also found that increased keratinocyte proliferation in PR-treated and CTR mice results in more cells in the skin (data not shown).…”

Section: Ne Promotes the Growth Of Hfmentioning

confidence: 75%

Norepinephrine Regulates Keratinocyte Proliferation to Promote the Growth of Hair Follicles

Kong

Liu

Pan

et al. 2016

Cells Tissues Organs

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Psychological factors and stress can cause hair loss. The sympathetic-adrenal-medullary (SAM) axis has been reported to regulate the growth of hair follicles (HF). The sympathetic nerve is a component of the SAM axis, but it has not been sufficiently or convincingly linked to hair growth. In this study, we demonstrate that chemical sympathectomy via administration of the neurotoxin 6-hydroxydopamine (6-OHDA) to mice inhibited HF growth, but treatment with the β-adrenoceptor antagonist propranolol (PR) had no effect. HF length and skin thickness were greater in PR-treated and control mice than in 6-OHDA-treated mice, as evidenced by hematoxylin and eosin staining. Furthermore, we found that the reduced HF growth in sympathectomized animals was accompanied by a decreased keratinocyte proliferation. Moreover, the neurotransmitter norepinephrine (NE) was found to efficiently promote HF growth in an organotypic skin culture model. Together, these findings suggest that sympathetic nerves regulate keratinocyte behaviors to promote hair growth, providing novel insights into stress-related, chemotherapy-, and radiotherapy-induced alopecia.

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“…Furthermore, DPs help neighboring epidermal cells to differentiate into cells of hair follicle lineages [5, 30]. Other paracrine and signaling pathways, such as Wnt/β-catenin/BMP, FGF and IGF, in DPLTs also should be evaluated in a further study [4, 16, 21]. …”

Section: Discussionmentioning

confidence: 99%

Hair growth promoting effect of dermal papilla like tissues from canine adipose-derived mesenchymal stem cells through vascular endothelial growth factor

Lee

Bae

Lee

et al. 2016

The Journal of Veterinary Medical Science

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The purpose of this study was to investigate the protein expression pattern and the in vivo trichogenicity of dermal papilla-like tissues (DPLTs) made from canine adipose-derived mesenchymal stem cells (ASCs) in athymic nude mice. Canine ASCs were isolated and cultured from adipose tissue, and differentiation was induced by culturing ASCs in dermal papilla forming media. DPLTs were embedded in collagen gel, and their structural characteristics and protein expression were evaluated by hematoxylin and eosin stain and immunohistochemistry. Athymic nude mice were divided into two groups (control and DPLTs groups), and DPLTs were injected in skin wounds of mice in the DPLTs group. The trichogenicity of DPLTs was assessed by gross and histological evaluations for 30 days. The fate and the growth factor-secretion effect of DPLTs were evaluated by immunohistochemistry and Western blotting. DPLTs have a compact aggregated structure, form extracellular matrix and highly express the protein specific for dermal papillae, including ALP and versican. New hair follicle formation was remarkable in nude mice of the DPLTs group in gross findings and H&E stain. Vascularization was increased in the DPLTs group, which was the effect of vascular endothelial growth factor secreted by DPLTs in vitro and in vivo. These data suggest that engineered canine DPLTs have characteristics of dermal papillae and have a positive effect on hair regeneration by secreting growth factors.

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Fibroblast Growth Factors Stimulate Hair Growth throughβ-Catenin and Shh Expression in C57BL/6 Mice

Cited by 111 publications

References 41 publications

A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification

A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification

Norepinephrine Regulates Keratinocyte Proliferation to Promote the Growth of Hair Follicles

Hair growth promoting effect of dermal papilla like tissues from canine adipose-derived mesenchymal stem cells through vascular endothelial growth factor

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