Effect of Curcumin Supplementation on Physiological Fatigue and Physical Performance in Mice

Huang, Wen-Ching; Chiu, Wan‐Chun; Chuang, Hsiao-Li; Tang, Deh-Wei; Lee, Zon-Min; Wei, Li; Chen, Fu‐An; Huang, Chi‐Chang

doi:10.3390/nu7020905

Cited by 127 publications

(144 citation statements)

References 43 publications

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“…The results also revealed that the swimming times to exhaustion of the supplemented groups were 36.23 (AVII) and 37.97 (SBWII) per cent longer than that of the control group. Reduction in the physiological fatigue and increase in the physical performance due to supplementation of Curcumin for enhanced muscular glycogen content on Swiss mice was also reported (Huang et al, 2015). In the present study the increase in swimming time with concomitant reduction in fatigue might be due to the presence of health promoting bio constituents present in PHG containing various herbs (Jung et al, 2004).…”

Section: Anti-fatigue Activitysupporting

confidence: 71%

Development of Poly Herbal Granules and its Anti-Fatigue Efficacy in Swiss Mice

Devi¹,

Nalwade²,

Rajurkar³

2017

Int.J.Curr.Microbiol.App.Sci

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The current study sought to investigate the anti-fatigue efficacy of poly herbal granule (PHG) formulations of the extracts of Asparagus racemosus, Chlorophytum borivilianum, Tinospora cordifolia, Tribulus terrestris and Withania somnifera enriched with general tonic and health promoting properties based on Aloe vera gel and soyabean whey in Swiss mice. The nutrient compositions of the selected PHG exhibited that the carbohydrates were the major constituents in both AVII and SBWII, followed by protein and total ash. Fat contents were 0.96 and 1.18 g100g -1 in AVII and SBWII, respectively. The energy levels of AVII and SBWII were 378 and 377 kcal100g -1 , correspondingly. Higher contents of Ca (70.20 mg100g -1 ), Mg (85.27mg100g -1 ) and P (61.55 mg100g -1 ) were observed in SBWII. The trace elements revealed that, Zn and Fe content were 1.84 and 8.63mg100g-1 in AVII and 1.85 and 7.85mg100g -1 in SBWII, respectively. The retention and stability of Vitamin C, total sugar, reducing sugar and non-reducing sugar for 270 days illustrated the storage life of the product in ambient condition. The body weight of mice, swimming time and corresponding biochemical parameters including haemoglobin, serum protein and blood glucose level were measured by standard method. The oral administration with PHG supplement for 30 days markedly increased the body weight (11.40-11.80%), haemoglobin (11.82-12.46%), serum protein (3.77-6.02%) of the mice. Following forced swimming test (FST), prolonged exhaustive exercise time of 231.02 (AVII), 237.50 (SBWII) minutes were recorded for PHG supplemented groups which were 36.23 (AVII) and 37.97 (SBWII) per cent longer than that of the control group. The minute increase of blood glucose levels (4.51-4.37%) in PHG supplemented Swiss mice after FST as compared to tremendous increase in blood glucose level (40.07%) in the control group illustrated the anti-fatigue activity of PHG. K e y w o r d s

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Section: Anti-fatigue Activitysupporting

confidence: 71%

Development of Poly Herbal Granules and its Anti-Fatigue Efficacy in Swiss Mice

Devi¹,

Nalwade²,

Rajurkar³

2017

Int.J.Curr.Microbiol.App.Sci

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“…The swimming exercise performance test was performed as previously described [20]. After 4 weeks of CAP supplementation, a lead sheet (5% equivalent to individual body weight) was attached to the tail of mice for exhaustive swimming challenge.…”

Section: Methodsmentioning

confidence: 99%

“…A previous article reviewed the physiological effects on energy metabolism and utilization via TRPV1 activation [15]. Therefore, we conducted this study to evaluate the potential ergogenic and anti-fatigue effects of CAP using our previously established in vivo platform [19,20]. …”

Section: Introductionmentioning

confidence: 99%

Capsaicin Supplementation Reduces Physical Fatigue and Improves Exercise Performance in Mice

et al. 2016

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Chili pepper is used as a food, seasoning and has been revered for its medicinal and health claims. It is very popular and is the most common spice worldwide. Capsaicin (CAP) is a major pungent and bioactive phytochemical in chili peppers. CAP has been shown to improve mitochondrial biogenesis and adenosine triphosphate (ATP) production. However, there is limited evidence around the effects of CAP on physical fatigue and exercise performance. The purpose of this study was to evaluate the potential beneficial effects of CAP on anti-fatigue and ergogenic functions following physiological challenge. Female Institute of Cancer Research (ICR) mice from four groups (n = 8 per group) were orally administered CAP for 4 weeks at 0, 205, 410, and 1025 mg/kg/day, which were respectively designated the vehicle, CAP-1X, CAP-2X, and CAP-5X groups. The anti-fatigue activity and exercise performance was evaluated using forelimb grip strength, exhaustive swimming time, and levels of serum lactate, ammonia, glucose, BUN (blood urea nitrogen) and creatine kinase (CK) after a 15-min swimming exercise. The grip strength and exhaustive swimming time of the CAP-5X group were significantly higher than other groups. CAP supplementation dose-dependently reduced serum lactate, ammonia, BUN and CK levels, and increased glucose concentration after the 15-min swimming test. In addition, CAP also increased hepatic glycogen content, an important energy source for exercise. The possible mechanism was relevant to energy homeostasis and the physiological modulations by CAP supplementation. Therefore, our results suggest that CAP supplementation may have a wide spectrum of bioactivities for promoting health, performance improvement and fatigue amelioration.

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“…Some investigations have evaluated for the effect of curcumin on DOMS (21)(22)(23)(24). However, to the best of our knowledge, no study to date has tested administration of 150mg curcumin supplement immediately after intensive eccentric exercise.…”

Section: Nakhostinmentioning

confidence: 99%

The Effect of Curcumin Supplementation on Selected Markers of Delayed Onset Muscle Soreness (DOMS)

Nakhostin-Roohi

Moradlou

Hamidabad

et al. 2016

Ann. Appl. Sport Sci.

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Inflammation and pain induced by delayed onset muscle soreness (DOMS) can be induced by eccentric exercise or an unaccustomed activity. The condition can causes problems in exercising and for athletes. The purpose of this study was to assess the effect of 150mg curcumin supplementation immediately after intensive eccentric exercise. Evaluations were made for total antioxidant Capacity (TAC), muscle damage markers, and DOMS induced pain. Ten healthy young males (age, 25.0 ± 1.6 years; height, 178.9 ± 4.1 cm; body mass, 81.1 ± 6.8 kg; fat%, 14.2 ± 2.1) completed a double blind randomized-controlled crossover trial to estimate the effects of oral curcumin supplementation (150mg) and a placebo on squat performance and DOMS following unaccustomed heavy eccentric exercise. Curcumin (CU) or placebo (P) was taken at the prescribed dose immediately after eccentric squat exercises; administrations were separated by a 14-day washout period. Measurements were made at the baseline, immediately, 24, 48, and 72h after exercise comprising: (a) limb pain (1-10 cm visual analogue scale; VAS), (b) total antioxidant capacity (TAC) (c) serum markers of muscle damage and inflammation. Measurements taken after exercise showed significantly reduced levels of pain, creatine kinase (CK), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) in C group compared with group P group (P<0.05). TAC remained significantly high in group C after exercise compared with levels in group P (P<0.05). The findings of this study suggest that a 150mg dose of curcumin may have antioxidant, anti-inflammatory and analgesic effects on DOMS.

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Effect of Curcumin Supplementation on Physiological Fatigue and Physical Performance in Mice

Cited by 127 publications

References 43 publications

Development of Poly Herbal Granules and its Anti-Fatigue Efficacy in Swiss Mice

Development of Poly Herbal Granules and its Anti-Fatigue Efficacy in Swiss Mice

Capsaicin Supplementation Reduces Physical Fatigue and Improves Exercise Performance in Mice

The Effect of Curcumin Supplementation on Selected Markers of Delayed Onset Muscle Soreness (DOMS)

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