First-trimester plasma tocopherols are associated with risk of miscarriage in rural Bangladesh

Shamim, Abu Ahmed; Schulze, Kerry; Merrill, Rebecca D.; Kabir, Alamgir; Christian, Parul; Shaikh, Saijuddin; Wu, Lee; Ali, Hasmot; Labrique, Alain; Mehra, Sucheta; Klemm, Rolf; Rashid, Mahbubur; Sungpuag, Pongtorn; Udomkesmalee, Emorn; West, Keith P.

doi:10.3945/ajcn.114.094920

Cited by 50 publications

(59 citation statements)

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“…It was stated that there is evidence in pregnant women that shows a significantly increased rate of miscarriage with a vitamin E concentration < 12 μmol/L (Shamim et al, 2015), which corresponds to the concentration at which an increased risk of haemolysis was observed by Horwitt (1960). It was suggested that DRVs should be set using serum vitamin E concentration as a biomarker, taking into account the negative impact on health of concentrations < 12 μmol/L.…”

Section: Outcome Of a Public Consultation On A Draft Scientific Opinimentioning

confidence: 99%

Section: Panel Consideration Of Comments Receivedmentioning

confidence: 99%

“…Although it is acknowledged that a revision of the UL is not within the current DRV mandate, it was asked to give an explanation within the text on why it has not been reviewed. 4. It was asked that the section on excess be considered in the context that there were insufficient data to use a biomarker to identify a level on which to base DRVs.…”

Section: Excessmentioning

confidence: 99%

“…It was suggested that DRVs should be set using serum vitamin E concentration as a biomarker, taking into account the negative impact on health of concentrations < 12 μmol/L. Given the animal data on the essential role of vitamin E on embryonic development, and the recently published study by Shamim et al (2015) showing a significantly increased rate of miscarriage with a vitamin E concentration < 12 μmol/L, it was suggested that women with a low intake of vitamin E may be at risk of adverse effects on the fetus. Additionally, it was stated that there is a link between maternal vitamin E status and the development of asthma and allergies in the offspring (Cook-Mills, 2015).…”

Section: The Setting Of Drvs For Pregnant and Lactating Womenmentioning

confidence: 99%

“…The Panel also notes that plasma α-tocopherol concentrations of these pregnant women were lower than mean maternal concentrations in Western countries such as the US and Ireland, i.e., respectively, 31.3 µmol/L at delivery (Pressman et al, 2003) and 20.6 µmol/L at 10-20 weeks of gestation (Kiely et al, 1999) (Section 5.2. of the Scientific Opinion). The Panel considers that the study by Shamim et al (2015) cannot be used to derive DRVs for α-tocopherol in pregnant women in the EU.The narrative review by summarises data on the development of allergic disease early in life and the impact of environmental factors on this development. In particular, it points out animal data suggesting that supplementation with α-tocopherol during gestation or lactation may play a role in risk of allergy in pups.…”

mentioning

confidence: 99%

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Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for vitamin E as ɑ‐tocopherol

2015

EFSA Supporting Publications

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The European Food Safety Authority (EFSA) carried out a public consultation to receive input from the scientific community and all interested parties on the draft Scientific Opinion on Dietary Reference Values (DRVs) for vitamin E as α-tocopherol, prepared by the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA Panel) and endorsed by the Panel for public consultation at its Plenary meeting on 5 February 2015. The written public consultation for this document was open from 9 March 2015 to 13 April 2015. EFSA received comments from five interested parties. EFSA and its NDA Panel wish to thank all stakeholders for their contributions. The current report summarises the outcome of the public consultation, and includes a brief summary of the comments received and how the comments were addressed. The NDA Panel prepared an updated version of the Scientific Opinion on Dietary Reference Values for vitamin E as α-tocopherol taking into account the comments received. The Opinion was discussed and adopted at the NDA Plenary meeting on 11 June 2015, and is published in the EFSA Journal. © European Food Safety Authority, 2015Reproduction is authorised provided the source is acknowledged. Outcome of a public consultation on a Draft Scientific Opinion on Dietary Reference Values for vitamin E as α-tocopherolwww.efsa.europa.eu/publications 3 EFSA Supporting publication 2015:EN-844 Terms of ReferenceIn line with EFSA's policy on openness and transparency, and in order for EFSA to receive comments from the scientific community and stakeholders, EFSA shall release the Draft Scientific Opinion on Dietary Reference Values for vitamin E as α-tocopherol for public consultation. The comments resulting from the public consultation shall be published in a technical report.Before its adoption by the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA Panel), the Draft Scientific Opinion on Dietary Reference Values for vitamin E as α-tocopherol needs to be revised, taking into account the comments received during the public consultation. ConsiderationUpon request from the European Commission and following previously published Scientific Opinions on Dietary Reference Values for macronutrients, energy, water, and several micronutrients, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA Panel) developed a Draft Scientific Opinion on Dietary Reference Values (DRVs) for vitamin E as α-tocopherol. In line with EFSA's policy on openness and transparency, and in order for EFSA to receive comments on its work from the scientific community and stakeholders, EFSA engages in public consultations on key issues. Accordingly, the draft Scientific Opinion was published on EFSA's website for comments (9 March to 13 April 2015) (see Appendix A). The NDA Panel prepared an updated version of the Scientific Opinion, taking into account the comments received. The updated Scientific Opinion was discussed and adopted at the NDA Plenary meeting on 11 June 2015, and is published in the EFSA Journal (EFSA NDA Panel, 20...

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Section: Outcome Of a Public Consultation On A Draft Scientific Opinimentioning

confidence: 99%

Section: Panel Consideration Of Comments Receivedmentioning

confidence: 99%

Section: Excessmentioning

confidence: 99%

Section: The Setting Of Drvs For Pregnant and Lactating Womenmentioning

confidence: 99%

mentioning

confidence: 99%

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Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for vitamin E as ɑ‐tocopherol

2015

EFSA Supporting Publications

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Maternal diet as a risk factor for primary congenital glaucoma and defects of the anterior segment of the eye in the National Birth Defects Prevention Study

Moore

Carmichael

Forestieri

et al. 2020

Birth Defects Research

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Primary congenital glaucoma (PCG) and anterior segment defects (ASDs) are rare ocular malformations diagnosed early in life which can cause blindness. Pathogenic variants in several genes have been linked to these conditions, but little is known about nongenetic risk factors. We investigated the association between maternal nutrition and PCG and ASDs in the National Birth Defects Prevention Study, a large population‐based, multicenter case–control study of major birth defects in the United States. Mothers of cases (n = 152) and control infants without a birth defect (n = 9,178) completed an interview which included a food frequency questionnaire capturing usual dietary intake in the year before pregnancy. Maternal nutrition was assessed through individual nutrient intake, calculating a Diet Quality Index for Pregnancy (DQI‐P) score for each mother, and using latent class analysis to empirically derive four dietary patterns. We calculated adjusted odds ratios (aORs) and 95% confidence intervals (CI) using logistic regression. The results for individual nutrients varied, with some having an inverse or U‐shaped pattern of association with increasing intake. The DQI‐P was not associated with risk of PCG and ASDs (aOR 0.91; CI 0.49–1.66, highest vs. lowest quartile). The dietary pattern analysis suggested lower odds among women with a Prudent and Mexican dietary pattern (aOR 0.82, 95% CI 0.52–1.29; aOR 0.80, 95% CI 0.36–1.78, respectively) compared to those with a Western dietary pattern. We found that higher intake of some nutrients and certain dietary patterns may be inversely associated with PCG and ASDs, though caution is urged due to imprecision of estimates.

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100 Years of Vitamin E: From Discovery to Commercialization

et al. 2022

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First-trimester plasma tocopherols are associated with risk of miscarriage in rural Bangladesh

Cited by 50 publications

References 40 publications

Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for vitamin E as ɑ‐tocopherol

Outcome of a public consultation on the Draft Scientific Opinion of the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) on Dietary Reference Values for vitamin E as ɑ‐tocopherol

Maternal diet as a risk factor for primary congenital glaucoma and defects of the anterior segment of the eye in the National Birth Defects Prevention Study

100 Years of Vitamin E: From Discovery to Commercialization

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