Intrapancreatic ectopic splenic tissue found in a cloned miniature pig

Koo, Ok Jae; Ha, Sungji; Park, Sol Ji; Park, Hee Jung; Kim, Su Jin; Kwon, Dohoon; Kang, Jung Taek; Moon, Joon Ho; Park, Eun Jung; Jang, Goo; Lee, Byeong Chun

doi:10.4142/jvs.2015.16.2.241

Cited by 4 publications

(7 citation statements)

References 6 publications

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“…On the other hand, the presence of a fibrous capsule partially separating the adjacent pancreatic parenchyma from the accessory spleen was observed a few of the animals studied (2/8 cases). A fibrotic capsule surrounding accessory spleens has also been observed in previous studies in minipigs ( 9 ) and other animals ( 8 , 16 ), suggesting that capsule formation is not related to the animal species. Regarding the presence of trabeculae, it should be noted that all wild boars in the study with confirmed presence of IPAS had trabecular connective tissue.…”

Section: Discussionsupporting

confidence: 72%

“…The description of intrapancreatic accessory spleen (IPAS) is a frequent phenomenon in humans that poses no clinical significance (4,6). However, the occurrence of IPASs in animals is poorly documented in the literature, with only a few cases described in dogs and cats (5,7,8), domestic pigs (9,10), rabbits (3,(11)(12)(13), marine mammals (14)(15)(16)(17) and non-human primates (18).…”

Section: Introductionmentioning

confidence: 99%

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Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa)

Porras,

Chinchilla,

Rodríguez-Bertos

et al. 2023

Front. Vet. Sci.

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Intrapancreatic accessory spleen (IPAS) is one of the most frequent congenital splenic anomalies in humans; however, studies in veterinary medicine are scarce. This study aimed to describe the macroscopic, histopathological and immunohistochemical features of 11 suspected cases of IPAS in wild boar piglets of 3–4 months old. Seven of the 11 animals were immunised with a low virulence isolate of African swine fever virus (ASFV) and subsequently challenged with a highly virulent ASFV isolate (LVI-HVI group). The remaining four animals were exclusively infected with a highly virulent isolate of ASFV (HVI group). Grossly, lesions comprised focal or multifocal reddish areas of variable shape, located on the surface of the pancreatic tail or within the parenchyma. Histological and immunohistochemical studies (anti-CD79 and CD3) confirmed the presence of IPAS in eight of the 11 cases. IPAS shared the same histological structure and alterations as those observed in the original spleen. The immunohistochemical study against ASFV revealed the presence of VP72+ cells in both the spleen and IPAS of seven of the eight piglets. The results of this study describe for the first time the presence of IPAS in ASFV infection of wild boar (Sus scrofa) regardless the isolate and suggest that the infection may induce the development of ectopic splenic tissue due to an increased demand for phagocytic cells from the reticuloendothelial system. However, further studies are needed to understand the immunological mechanisms that trigger the formation of these accessory organs.

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Section: Discussionsupporting

confidence: 72%

Section: Introductionmentioning

confidence: 99%

Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa)

Porras,

Chinchilla,

Rodríguez-Bertos

et al. 2023

Front. Vet. Sci.

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“…3 Ectopic spleen has been recorded in the pancreas of a cloned Yucatan minipig, and accessory spleens may be found in the gastrosplenic ligament. 4 As the parathyroid is often found embedded in the cervical thymus, it is not considered an ectopic tissue in this location.…”

Section: Chapter 2 Systemic Pathologymentioning

confidence: 99%

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Minipig

et al. 2021

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions) Project ( www.toxpath.org/inhand.asp ) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP), and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in most tissues and organs from the minipig used in nonclinical safety studies. Some of the lesions are illustrated by color photomicrographs. The standardized nomenclature presented in this document is also available electronically on the internet ( http://www.goreni.org/ ). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous lesions as well as lesions induced by exposure to test materials. Relevant infectious and parasitic lesions are included as well. A widely accepted and utilized international harmonization of nomenclature for lesions in laboratory animals will provide a common language among regulatory and scientific research organizations in different countries and increase and enrich international exchanges of information among toxicologists and pathologists.

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“…Intrapancreatic splenic tissue (IPST) is sporadically reported in veterinary species, including dogs, 1 cats, 1,2 rabbits, 3,4 pigs, 5,6 cetaceans 7 and non-human primates. 8,9 IPST can have two possible origins, indistinguishable on histopathology: splenosis, which consists in autotransplantation of splenic tissue in a patient (ie, following trauma); or accessory spleen, which consists of aberrantly located splenic masses of congenital origin.…”

Section: Introductionmentioning

confidence: 99%

Ultrasonographic and colour Doppler features of intrapancreatic splenic tissue in a cat

Peschard

Jamont

Shields

et al. 2022

Journal of Feline Medicine and Surgery Open Reports

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Case summary A 2-year-old female neutered domestic longhair cat was referred for a 3-day history of lethargy and anorexia. Physical examination documented abdominal distension and pain, which, alongside marked electrolyte imbalances on blood biochemistry, was highly suspicious for a gastrointestinal obstruction. This was confirmed on diagnostic imaging, with abdominal ultrasonography also identifying an incidental, well-defined small lobular hypoechoic nodule adjacent to the tail of the spleen, with high vascularity on Doppler interrogation. This was identified as a focal nodule at the tip of the left limb of the pancreas at surgery, and resected via partial pancreatectomy. Histopathological examination confirmed intrapancreatic splenic tissue. Relevance and novel information This case report presents the first available ultrasonographic description and images of intrapancreatic splenic tissue in a cat. It is thought to be a benign lesion of low clinical significance and therefore defining its imaging characteristics may allow for improvement in diagnostic suspicion without resorting to excisional surgery.

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Intrapancreatic ectopic splenic tissue found in a cloned miniature pig

Cited by 4 publications

References 6 publications

Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa)

Intrapancreatic accessory spleens in African swine fever infection of wild boar (Sus scrofa)

International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Nonproliferative and Proliferative Lesions of the Minipig

Ultrasonographic and colour Doppler features of intrapancreatic splenic tissue in a cat

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