Vitamin A, vitamin E, iron and zinc status in a cohort of HIV-infected mothers and their uninfected infants

Monteiro, Jacqueline Pontes; Cruz, Maria Letícia Santos; Mussi-Pinhata, Marisa Márcia; Salomão, Roberta Garcia; Jordão, Alceu Afonso; Read, Jennifer S.; Pilotto, José H.; Cohen, Rachel; Stoszek, Sonia K.; Siberry, George K.

doi:10.1590/0037-8682-0226-2014

Cited by 2 publications

(2 citation statements)

References 43 publications

(40 reference statements)

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“…No study reported prevalence among non-pregnant and non-breastfeeding women. Gurgel et al 29 did not report on the use of medicines or supplements and Monteiro et al 30 only reported on the use of antiretroviral therapy. Furthermore, most of the studies did not report mean BMI, ethnicity, educational level or per capita income.…”

Section: Characteristics Of Studies and Participantsmentioning

confidence: 99%

“…Eleven studies reported on the prevalence of deficiency or insufficiency of vitamin E. 12,14,[29][30][31][33][34][35][36][37][38][39] Different cutoffs for alpha-tocopherol in plasma were used, but a meta-analysis with three subgroups could be conducted. Machado et al 12 and Monteiro et al 30 were not included in any vitamin E meta-analysis because their cutoffs of < 9.7 mmol/l, 9.7-16.2 mmol/l and < 7 mmol/l were not used in any other study.…”

Section: Prevalence Analysismentioning

confidence: 99%

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Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis

et al. 2021

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BACKGROUND: Despite the several options available for supplements containing vitamins C and E, evidence regarding the prevalence of deficiency or insufficiency of these vitamins is weak. OBJECTIVES: To estimate the prevalence of deficiency or insufficiency of vitamins C and E and associated factors among women of childbearing age, in Brazil. DESIGN AND SETTING: Systematic review and meta-analysis conducted at a Brazilian public university. METHODS: A search from index inception until May 2020 was conducted. Meta-analyses were performed using inverse variance for fixed models, with summary proportions calculation using Freeman-Tukey double arcsine (base case). Reporting and methodological quality were assessed using the Joanna Briggs Institute tool for prevalence studies. RESULTS: Our review identified 12 studies, comprising 1,316 participants, especially breastfeeding women. There was at least one quality weakness in all studies, mainly regarding sampling method (i.e. convenience sampling) and small sample size. The prevalence of vitamin C deficiency ranged from 0% to 40%. Only vitamin E deficiency was synthetized in meta-analyses, with mean prevalences of 6% regardless of the alpha-tocopherol cutoff in plasma, and 5% and 16% for cutoffs of < 1.6-12.0 mmol/l and < 16.2 mmol/l, respectively. The cumulative meta-analysis suggested that a trend to lower prevalence of vitamin E deficiency occurred in recent studies. CONCLUSIONS: Although the studies identified in this systematic review had poor methodological and reporting quality, mild-moderate vitamin C and E deficiencies were identified, especially in breastfeeding women. Thus, designing and implementing policies does not seem to be a priority, because the need has not been properly dimensioned among women of childbearing age in Brazil. REGISTRATION NUMBER IN PROSPERO: CRD42020221605.

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Section: Characteristics Of Studies and Participantsmentioning

confidence: 99%

Section: Prevalence Analysismentioning

confidence: 99%

Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis

et al. 2021

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Vitamin E deficiency in childhood: a narrative review

Lobo

Hadler²

2022

Nutr. Res. Rev.

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Vitamin E is an important nutrient from the earliest stages of life. It plays key roles as an antioxidant and in the maintenance of the immune system, among others. Vitamin E deficiency (VED), which occurs more frequently in children, is rarely addressed in the literature. This narrative review aims to summarize the chemistry, biology, serum indicators, and clinical trials that have evaluated the impact of fortification and other relevant aspects of vitamin E, in addition to the prevalence of its deficiency, in children worldwide. Vitamin E intake in recommended amounts is essential for this nutrient to perform its functions in the body. Serum α-tocopherol is the most widely used biochemical indicator to assess the prevalence of VED. VED has been associated with symptoms secondary to fat malabsorption and may lead to peripheral neuropathy and increased erythrocyte hemolysis. Reduced concentrations of α-tocopherol may be caused by the combination of diets with low amounts of vitamin E, associated with inadequate consumption of fats, proteins, and calories. The lowest prevalence of vitamin E deficiency was found in Asia and the highest, in North America and Brazil. High proportions of VED provide evidence that this nutritional deficiency is a public health problem in children and still little addressed in the international scientific literature. The planning, evaluation, and implementation of health policies aimed at combating vitamin E deficiency in the pediatric population are extremely important.

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Vitamin A, vitamin E, iron and zinc status in a cohort of HIV-infected mothers and their uninfected infants

Cited by 2 publications

References 43 publications

Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis

Deficiency of vitamins C and E in women of childbearing age in Brazil: a systematic review and meta-analysis

Vitamin E deficiency in childhood: a narrative review

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