Diffuse Decreased Gray Matter in Patients with Idiopathic Craniocervical Dystonia: A Voxel-Based Morphometry Study

Piccinin, Camila; Piovesana, Luiza; Santos, Maria Carolina dos; Guimarães, Rachel; Campos, Brunno Machado de; Rezende, Thiago Junqueira Ribeiro de; Campos, Lidiane; Torres, Fábio R.; Amato-Filho, Augusto; França, Marcondes C.; Lopes-Cendes, Íscia; Cendes, Fernando; D’Abreu, Anelyssa

doi:10.3389/fneur.2014.00283

Cited by 31 publications

(43 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This corresponds with neuroimaging data of idiopathic dystonia that points toward dysfunction in the putamen and caudate nucleus (e.g., Lehèricy et al, 2013). Further, grey matter changes in CD were reported in the cingulate cortex and precuneus (Piccinin et al, 2015) additional brain regions implicated in ToM processing. This is the first study to report disturbances in social cognition in patients with CD.…”

Section: Discussionmentioning

confidence: 95%

Social cognition and idiopathic isolated cervical dystonia

et al. 2017

View full text Add to dashboard Cite

For a long time, cervical dystonia (CD) has been characterised only by disturbances in motor functioning. Despite accumulating evidence for symptomatology in various non-motor domains, to date no study has investigated social cognition in CD. The aim of this study was to compare performance of CD patients and healthy controls in neurocognitive and socio-cognitive domain. Twenty-five non-depressed patients with CD and 26 healthy controls underwent neuropsychological testing. This involved assessment of cognitive status (general intellect, verbal memory, and executive function), and socio-cognitive functions using a Theory of mind task and self-report on empathy and emotion regulation. In comparison to controls, CD patients displayed significantly decreased cognitive abilities, particularly in executive function and verbal memory tasks. Difficulties in inferring mental states on both cognitive and affective levels were also observed. The largest discrepancies were detected in understanding intentionality in others. Poorer performance in cognitive and socio-cognitive tasks was unrelated to severity of the disease. This is the first evidence of compromised socio-cognitive functions in CD patients, highlighting this domain as another facet of non-motor symptoms of this disease. Future studies should advance our understanding of the extent, nature, and time course of these deficits in other aspects of social cognition in this patient population.

show abstract

Section: Discussionmentioning

confidence: 95%

Social cognition and idiopathic isolated cervical dystonia

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Another DTI study showed that persons with CD had decreased axonal fiber organization in the superior cerebellar peduncles, which carry the output fibers from the cerebellum to the thalamus and brainstem (53). Voxel-based morphometry studies in CD have demonstrated abnormalities in cerebellar gray matter volume, including the anterior cerebellum (15, 17, 52, 54, 55). PET studies have indicated increased glucose metabolism in the cerebellar hemispheres bilaterally (22).…”

Section: Discussionmentioning

confidence: 99%

A Functional Magnetic Resonance Imaging Study of Head Movements in Cervical Dystonia

et al. 2016

View full text Add to dashboard Cite

Cervical dystonia (CD) is a neurological disorder characterized by abnormal movements and postures of the head. The brain regions responsible for these abnormal movements are not well understood, because most imaging techniques for assessing regional brain activity cannot be used when the head is moving. Recently, we mapped brain activation in healthy individuals using functional magnetic resonance imaging during isometric head rotation, when muscle contractions occur without actual head movements. In the current study, we used the same methods to explore the neural substrates for head movements in subjects with CD who had predominantly rotational abnormalities (torticollis). Isometric wrist extension was examined for comparison. Electromyography of neck and hand muscles ensured compliance with tasks during scanning, and any head motion was measured and corrected. Data were analyzed in three steps. First, we conducted within-group analyses to examine task-related activation patterns separately in subjects with CD and in healthy controls. Next, we directly compared task-related activation patterns between participants with CD and controls. Finally, considering that the abnormal head movements in CD occur in a consistently patterned direction for each individual, we conducted exploratory analyses that involved normalizing data according to the direction of rotational CD. The between-group comparisons failed to reveal any significant differences, but the normalization procedure in subjects with CD revealed that isometric head rotation in the direction of dystonic head rotation was associated with more activation in the ipsilateral anterior cerebellum, whereas isometric head rotation in the opposite direction was associated with more activity in sensorimotor cortex. These findings suggest that the cerebellum contributes to abnormal head rotation in CD, whereas regions in the cerebral cortex are involved in opposing the involuntary movements.

show abstract

“…Median time of BoNT treatment was of 2.5 years (minimum of 0, maximum of 17), last injection at most 30 days prior to MRI scanning. All the subjects who were evaluated in our previous studies [ 14 , 16 ] were included in this one. Table 2 details demographics of the studied population.…”

Section: Methodsmentioning

confidence: 99%

“…[ 5 , 7 – 15 ] For instance, while older studies demonstrated increased [ 5 , 8 – 11 ] or decreased [ 5 , 7 ] grey matter (GM) in the basal ganglia, more recent ones [ 12 – 15 ] found no alterations in these regions. Previously we assessed CCD patients using VBM [ 14 , 16 ], showing GM increase in the anterior cerebellum and brainstem (pons), along with GM decrease in the posterior lobe of cerebellum [ 16 ]. A whole brain analysis confirmed atrophy in the supplementary motor area [ 8 , 11 ], premotor cortex [ 7 , 8 ], precentral gyrus [ 7 , 11 , 12 , 15 ], inferior parietal gyrus [ 9 ], superior temporal gyrus [ 5 , 12 ], visual cortex [ 8 ], anterior cingulate [ 15 ], precuneus, middle temporal gyrus [ 11 ] and cerebellum [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Previously we assessed CCD patients using VBM [ 14 , 16 ], showing GM increase in the anterior cerebellum and brainstem (pons), along with GM decrease in the posterior lobe of cerebellum [ 16 ]. A whole brain analysis confirmed atrophy in the supplementary motor area [ 8 , 11 ], premotor cortex [ 7 , 8 ], precentral gyrus [ 7 , 11 , 12 , 15 ], inferior parietal gyrus [ 9 ], superior temporal gyrus [ 5 , 12 ], visual cortex [ 8 ], anterior cingulate [ 15 ], precuneus, middle temporal gyrus [ 11 ] and cerebellum [ 14 ]. We showed neither atrophy nor increase in GM in the basal ganglia [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Exploratory structural assessment in craniocervical dystonia: Global and differential analyses

et al. 2017

Self Cite

View full text Add to dashboard Cite

IntroductionOur goal was to investigate the cortical thickness and subcortical volume in subjects with craniocervical dystonia and its subgroups.MethodsWe studied 49 subjects, 17 with cervical dystonia, 18 with blepharospasm or oromandibular dystonia, and 79 healthy controls. We performed a whole group analysis, followed by a subgroup analysis. We used Freesurfer software to measure cortical thickness, subcortical volume and to perform a primary exploratory analysis in the craniocervical dystonia group, complemented by a region of interest analysis. We also performed a secondary analysis, with data generated from Freesurfer for subgroups, corrected by false discovery rate. We then performed an exploratory generalized linear model with significant areas for the previous steps using clinical features as independent variables.ResultsThe primary exploratory analysis demonstrated atrophy in visual processing regions in craniocervical dystonia. The secondary analysis demonstrated atrophy in motor, sensory, and visual regions in blepharospasm or oromandibular dystonia, as well as in limbic regions in cervical dystonia. Cervical dystonia patients also had greater cortical thickness than blepharospasm or oromandibular dystonia patients in frontal pole and medial orbitofrontal regions. Finally, we observed an association between precuneus, age of onset of dystonia and age at the MRI exam, in craniocervical dystonia; between motor and limbic regions and age at the exam, clinical score and time on botulinum toxin in cervical dystonia and sensory regions and age of onset and time on botulinum toxin in blepharospasm or oromandibular dystonia.ConclusionsWe detected involvement of visual processing regions in craniocervical dystonia, and a pattern of involvement in cervical dystonia and blepharospasm or oromandibular dystonia, including motor, sensory and limbic areas. We also showed an association of cortical thickness atrophy and younger onset age, older age at the MRI exam, higher clinical score and an uncertain association with longer time on botulinum toxin.

show abstract

Diffuse Decreased Gray Matter in Patients with Idiopathic Craniocervical Dystonia: A Voxel-Based Morphometry Study

Cited by 31 publications

References 45 publications

Social cognition and idiopathic isolated cervical dystonia

Social cognition and idiopathic isolated cervical dystonia

A Functional Magnetic Resonance Imaging Study of Head Movements in Cervical Dystonia

Exploratory structural assessment in craniocervical dystonia: Global and differential analyses

Contact Info

Product

Resources

About