256 Check: Cohort Hip and Cohort Knee; Similarities and Differences With the Oa Initiative

Objective. To predict the 2-year course of activity limitations in patients with early knee and/or hip osteoarthritis (OA). Methods. The Cohort Hip & Cohort Knee (CHECK) study is a prospective followup study. The CHECK cohort, comprising participants (n ‫؍‬ 1,002) with early OA-related knee and/or hip symptoms, was followed for 2 years. Participants completed questionnaires and underwent physical, laboratory, and radiographic examination. Regression models were used to examine whether baseline variables predicted the course of activity limitations as measured with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Analyses were performed separately for participants with knee symptoms and participants with hip symptoms. Results. After 2 years of followup, activity limitations slightly decreased. Large between-subject variation was observed in WOMAC change scores. In participants with knee symptoms, young age, non-Western ethnicity, bilateral hip pain, morning stiffness in the knee, high comorbidity count, high body mass index, high bodily pain, poor general health perception, and pain coping strategy were associated with a poor 2-year outcome on activity limitations. In participants with hip symptoms, few activity limitations at baseline, bilateral hip pain, morning stiffness in the knee, high comorbidity count, low active hip flexion, poor general health perception, and pain coping strategy were associated with a poor 2-year outcome on activity limitations. Conclusion. After 2 years of followup, large between-subject variation was observed in the course of activity limitations. The course of activity limitations is to some extent already predictable at an early stage of knee and hip OA.

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Prognostic factors for the two‐year course of activity limitations in early osteoarthritis of the hip and/or knee

Holla¹,

Steultjens²,

Roorda³

et al. 2010

“…We used 5-year followup data from a sample of the Cohort Hip and Cohort Knee (CHECK) cohort with early symptomatic knee OA (27). Measurements were performed at baseline, after 2 years, and after 5 years, resulting in 3 measurements over time.…”

Section: Methodsmentioning

confidence: 99%

“…The CHECK cohort was formed between October 2002 and September 2005, and consists of 1,002 individuals with early symptomatic knee and/or hip OA (27). Ten academic and general hospitals in the Netherlands participated.…”

Section: Methodsmentioning

confidence: 99%

“…Exclusion criteria were having any other pathologic condition that could explain the knee and hip symptoms, having a comorbidity that would not allow physical evaluation and/or followup of at least 10-years duration, malignancy in the last 5 years, and inability to understand the Dutch language (27). For the present study we used data of all participants who reported knee pain at baseline (n ϭ 832) and who provided sufficient data to be included in at least 1 analysis (n ϭ 828 of 832).…”

Section: Methodsmentioning

confidence: 99%

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Predictors and Outcome of Pain‐Related Avoidance of Activities in Persons With Early Symptomatic Knee Osteoarthritis: A Five‐Year Followup Study

Holla

Leeden

Knol

et al. 2014

Objective. It has been hypothesized that pain and low vitality lead to an increase in avoidance of activities in persons with early symptomatic knee osteoarthritis (OA), and that avoidance of activities leads to an increase in activity limitations. The present study aimed to evaluate these hypotheses. Methods. Baseline, 2-year, and 5-year followup data of 828 participants from the Cohort Hip and Cohort Knee Study with early symptomatic knee OA were used. Autoregressive generalized estimating equations and linear regression models were used to analyze the longitudinal and cross-sectional associations between self-reported knee pain, vitality, painrelated avoidance of activities, and activity limitations. The models were adjusted for the covariates age, sex, education level, body mass index, comorbidity, radiographic severity, and hip pain. Results. In longitudinal analyses, knee pain and vitality predicted a subsequent increase in avoidance of activities. Pain-related avoidance of activities predicted a subsequent increase in activity limitations; however, this relationship lost statistical significance (P ‫؍‬ 0.089) after adjustment for covariates. Cross-sectional analyses showed strong relationships between knee pain, low vitality, pain-related avoidance of activities, and activity limitations at all time points. Conclusions. In persons with early symptomatic knee OA, knee pain and low vitality lead to a subsequent increase in avoidance of activities. Pain-related avoidance of activities is related to activity limitations at inception of symptoms, but also years later. Therefore, it can be recommended to monitor and target avoidance of activities at various stages of the disease.

Work participation and health status in early osteoarthritis of the hip and/or knee: A comparison between the cohort hip and cohort knee and the osteoarthritis initiative

Bieleman

Oosterveld

Oostveen

et al. 2010

Objective To examine the work participation of Dutch people with early osteoarthritis (OA) in hips or knees and compare this with data from the American Osteoarthritis Initiative (OAI) cohort. The influence of health status and personal factors on work participation was analyzed. Methods In the Cohort Hip and Cohort Knee (CHECK) study, 1,002 subjects were included. Baseline questionnaire data from 970 subjects were analyzed. Rate ratios were calculated to compare work participation with the general Dutch population, after correcting (by stratifying) for age, sex, and education. Health status was measured using the Short Form 36 health survey and the Western Ontario and McMaster Universities Osteoarthritis Index. Groups were compared (CHECK versus OAI, workers versus nonworkers) using t-tests. Results The mean age of the subjects was 56 years and 79% were women. Overall participation was 51%, similar to the general Dutch population and lower than in the OAI (76%). Point prevalence of sick leave because of hip/knee symptoms was 2%, and year prevalence was 12%. Of the subjects, 14% had made work adaptations. Workers reported significantly better health status (corrected for age, sex, and education) than nonworkers. Conclusion Work participation of Dutch people with early OA is similar to the general population and significantly lower than American subjects. Increasing age, female sex, and lower education level were related to lower participation. Societal factors appear to have had more effect on work participation than health status in this stage of OA. The better health status of workers could not be explained solely by selection bias, but may be a result of work.