Elevated hypercoagulability markers in hemoglobin SC disease

Abstract

ABSTRACTincluded in the study was being treated with hydroxyurea. Patients who were on anticoagulation were excluded. A total of 56 HbSC patients were compared to a population of 39 HbSS patients, of whom 15 were described in a previous study. 17 We also selected 27 healthy age-matched HbAA controls. The University's ethics committee approved the study and all of the patients included signed a written informed consent form.Venous blood samples for all of the study analyses, including peripheral blood counts and hemolysis markers, were obtained simultaneously.

Effects of hydroxyurea treatment for patients with hemoglobin SC disease

“…Increasing the MCV, particularly if the Hb remains stable, should improve red cell rheology and reduce blood viscosity. Decreases in ANC and ARC may tamp down inflammation, reduce cellular expression of adhesion molecules, and decrease circulating microparticles . As it is metabolized, hydroxyurea may release nitric oxide, which could promote vasodilation and enhance blood flow , even if blood viscosity is minimally impacted.…”

Beta-Globin Haplotypes and Alpha-Thalassemia 3.7 kb Deletion in Sickle Cell Disease Patients From the Occidental Brazilian Amazon

“…Parameters such as MCV, MCH and RDW were higher in HbSS patients, corroborating surveys such as performed by Colella et al in patients with SCD attended in Hematologic and Center of Hematology and Hemotherapy (Sao Paulo, Brazil). In addition, a more pronounced leukocytosis among HbSS patients confirms the participation of leukocytes in the pathophysiology of the disease, likely due to the participation in vaso-occlusive events and not necessarily in infectious processes [27]. Several haplotypes distribution analyses of variants linked to the globin β S gene have been published using population samples from distinct Brazilian regions, with conflicting results.…”

Stroke in a Child with Hemoglobin SC Disease: A Case Report Describing Use of Hydroxyurea after Transfusion Therapy

“…Data in children are limited but findings of a cross-sectional observational study support increased risk of thromboembolic events in adults with HbSC disease. 15 There was observed increased expression of tissue factor, thrombin-antithrombin complex and D-dimer when compared to healthy controls, but levels in HbSC patients were lower than those in SCA patients. 15 The higher hemolytic activity and inflammation observed in HbSC patients were associated with retinopathy and osteonecrosis.…”

“…15 There was observed increased expression of tissue factor, thrombin-antithrombin complex and D-dimer when compared to healthy controls, but levels in HbSC patients were lower than those in SCA patients. 15 The higher hemolytic activity and inflammation observed in HbSC patients were associated with retinopathy and osteonecrosis. 15 …”

“…15 The higher hemolytic activity and inflammation observed in HbSC patients were associated with retinopathy and osteonecrosis. 15 …”