Comparison of penetration depth in choroidal imaging using swept source vs spectral domain optical coherence tomography

Sm, Waldstein; Faatz, Henrik; Szimacsek, Martin; Am, Glodan; Podkowinski, Dominika; Montuoro, Alessio; Simader, Christian; Gerendas, Bianca S.; Schmidt‐Erfurth, Ursula

doi:10.1038/eye.2014.319

Cited by 59 publications

(40 citation statements)

References 19 publications

(25 reference statements)

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“…Swept source OCT uses a long‐wavelength light source for accurate penetration and visualisation. It has been shown that signal penetration depths are similar for swept source OCT and spectral domain OCT using EDI . We used spectral domain EDI OCT for evaluation of the choroid in the current study.…”

Section: Discussionmentioning

confidence: 99%

Does the treatment of amblyopia normalise subfoveal choroidal thickness in amblyopic children?

Öner

Bulut

2017

Clinical and Experimental Optometry

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Section: Discussionmentioning

confidence: 99%

Does the treatment of amblyopia normalise subfoveal choroidal thickness in amblyopic children?

Öner

Bulut

2017

Clinical and Experimental Optometry

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“…The vessel contrast depends however on the light penetration into the choroid in individual eyes which also depends on the condition of ocular tissues. In diseases compromising the function of RPE and choriocapillaris, increased depth penetration of the imaging beam allows for better visualization of deep choroidal vessels [38,79,90], as demonstrated in the comparison between normal, AMD and GA cases. In projection images generated at the scleral level we also observed vessels located below Haller's layer.…”

Section: Discussionmentioning

confidence: 99%

Comparison of amplitude-decorrelation, speckle-variance and phase-variance OCT angiography methods for imaging the human retina and choroid

Gorczyńska¹,

Migacz²,

Zawadzki³

et al. 2016

Biomed. Opt. Express

133

112

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Abstract:We compared the performance of three OCT angiography (OCTA) methods: speckle variance, amplitude decorrelation and phase variance for imaging of the human retina and choroid. Two averaging methods, split spectrum and volume averaging, were compared to assess the quality of the OCTA vascular images. All data were acquired using a swept-source OCT system at 1040 nm central wavelength, operating at 100,000 A-scans/s. We performed a quantitative comparison using a contrast-to-noise (CNR) metric to assess the capability of the three methods to visualize the choriocapillaris layer. For evaluation of the static tissue noise suppression in OCTA images we proposed to calculate CNR between the photoreceptor/RPE complex and the choriocapillaris layer. Finally, we demonstrated that implementation of intensity-based OCT imaging and OCT angiography methods allows for visualization of retinal and choroidal vascular layers known from anatomic studies in retinal preparations. OCT projection imaging of data flattened to selected retinal layers was implemented to visualize retinal and choroidal vasculature. User guided vessel tracing was applied to segment the retinal vasculature. The results were visualized in a form of a skeletonized 3D model. Eye (Lond.) 4(2), 262-272 (1990). 4. B. Braaf, K. A. Vermeer, K. V. Vienola, and J. F. de Boer, "Angiography of the retina and the choroid with phase-resolved OCT using interval-optimized backstitched B-scans," Opt. Express 20(18), 20516-20534 (2012 "Real-time speckle variance swept-source optical coherence tomography using a graphics processing unit," Biomed. Opt. Express 3(7), 1557-1564 (2012 Garstecki, and M. Wojtkowski, "Differentiation of morphotic elements in human blood using optical coherence tomography and a microfluidic setup," Opt. Express 23(21), 27724-27738 (2015). 76. W. S. Rasband, "ImageJ," (U. S. National Institutes of Health, Bethesda, Maryland, USA, 1997USA, -2015

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“…Although photoacoustic imaging [Xia et al, 2014], optical coherence tomography [Waldstein et al, 2015], confocal reflectance microscopy [Olsovsky et al, 2013], and high frequency (>5 MHz) ultrasound [Wortsman, 2012;Botar-Jid et al, 2016] have been trialed clinically for the assessment of melanomas, no imaging modality, other than high frequency ultrasound, has entered clinical practice for estimating cutaneous melanoma thickness beyond 1.5 mm. Assessment of primary melanomas on the surface of the skin has also been proven to be difficult with conventional MRI, CT, and PET scanning.…”

Section: Introductionmentioning

confidence: 99%

Computational phantom study of frozen melanoma imaging at 0.45 terahertz

Vilagosh

Lajevardipour

Wood

2019

Bioelectromagnetics

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Terahertz radiation (THz) is highly absorbed by liquid water. This creates the possibility of medical imaging on the basis of the water content difference between normal and diseased tissue. The effective penetration of THz is limited, however, to a tissue depth of 0.2–0.3 mm at body temperature. A unique feature of the 0.1–2.0 THz frequency is that there is a high disparity between liquid water absorption and ice absorption, with ice being 100 times more permeable to the radiation than liquid water. This results in 90% of the radiation surviving to 1.0 mm in ice, permitting the imaging of frozen tissues to a depth of 5.0 mm. This method is practical as an in vivo procedure before or during surgical excision. Finite difference time domain (FDTD) computational modeling of frozen normal skin and frozen melanoma was undertaken using tissue phantoms. The study suggests that sufficient contrast exists to differentiate normal frozen skin and melanoma on the basis of the difference of water content alone. When the melanin pigment in melanomas is modeled as a significant absorber of THz, the contrast changes. Based on the modeling, further exploration of the “THz‐skin freeze” imaging technique is justified. In the modeling, the boundary between the frozen tissue and non‐frozen tissue is shown to be strongly reflective. If the reflective properties of the boundary are substantiated, the “THz‐skin freeze” technique will have applications in other areas of skin diagnostics and therapeutics. Bioelectromagnetics. 40:118–127, 2019. © 2019 Bioelectromagnetics Society

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Comparison of penetration depth in choroidal imaging using swept source vs spectral domain optical coherence tomography

Cited by 59 publications

References 19 publications

Does the treatment of amblyopia normalise subfoveal choroidal thickness in amblyopic children?

Does the treatment of amblyopia normalise subfoveal choroidal thickness in amblyopic children?

Comparison of amplitude-decorrelation, speckle-variance and phase-variance OCT angiography methods for imaging the human retina and choroid

Computational phantom study of frozen melanoma imaging at 0.45 terahertz

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