Abdominal Adiposity and Insulin Resistance in Early Pregnancy

Souza, Leanne R. De; Kogan, Eva; Berger, Howard; Alves, João Guilherme Bezerra; Lebovic, Gerald; Retnakaran, Ravi; Maguire, Jonathon L.; Ray, Joel G.

doi:10.1016/s1701-2163(15)30409-6

Cited by 35 publications

(40 citation statements)

References 33 publications

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“…Some studies investigated the relationship between glycemic status in pregnancy and sonographic thickness of maternal adipose tissue, mostly based on small groups of cases evaluated during the first trimester of pregnancy [11][12][13][14]. Bartha et al [11] examined 30 women at 11-14 weeks' gestation and found a significant association between sonographic measurement of visceral adipose tissue and glycemia, insulinemia, and insulin sensitivity.…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown that an excessive accumulation of adipose tissue into the visceral compartment is associated with an increased risk for metabolic disorders [7][8][9][10]. Some studies have investigated the measurement of maternal adipose compartments by ultrasound in patients with GDM, showing that an increased thickness of visceral adipose tissue in the first trimester of pregnancy was associated with subsequent development of metabolic disorders [11][12][13][14].…”

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confidence: 99%

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Maternal Subcutaneous and Visceral Adipose Ultrasound Thickness in Women with Gestational Diabetes Mellitus at 24-28 Weeks' Gestation

D’Ambrosi¹,

Crovetto²,

Colosi³

et al. 2017

Fetal Diagn Ther

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Objective: To compare the sonographic measurement of maternal subcutaneous and visceral adipose thickness between pregnant women with gestational diabetes mellitus (GDM) and patients with nondiabetic pregnancies. Methods: Adipose thickness was measured by transabdominal ultrasound in pregnant women attending our antenatal clinics at 24-28 weeks' gestation. All patients underwent a 75-g oral glucose challenge as a diagnostic test for GDM. Results: The study population comprised 56 women with a positive glucose challenge test and 112 nondiabetic pregnancies. Measurements of subcutaneous and visceral adipose tissues were converted into multiples of the median (MoM), adjusted for gestational age. The mean subcutaneous thickness MoM in patients with GDM was significantly higher compared to nondiabetic pregnancies (1.31 vs. 1.07; p = 0.011). Similarly, the mean visceral thickness MoM was higher in women with a positive oral glucose tolerance test compared to controls (1.61 vs. 1.06; p < 0.001). Multivariate logistic regression analysis demonstrated that visceral adipose thickness, but not subcutaneous thickness, was significantly and independently associated with GDM (odds ratio 34.047, 95% confidence interval 9.489-122.166). Conclusions: Sonographic thickness of maternal visceral adipose tissue at 24-28 weeks' gestation was higher in women with GDM compared to nondiabetic pregnancies, independently from other known risk factors associated with GDM.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Maternal Subcutaneous and Visceral Adipose Ultrasound Thickness in Women with Gestational Diabetes Mellitus at 24-28 Weeks' Gestation

D’Ambrosi¹,

Crovetto²,

Colosi³

et al. 2017

Fetal Diagn Ther

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“…Our finding concurs with the study done by De Souza et al where BMI and waist circumference was found to be significantly higher in cases than in controls. 12 The lipid profile of the study population showed a significantly higher value of Triglycerides among patients while the difference in HDL -Cholesterol levels were not significant. TGL values in cases was significantly higher than in controls, thus proving the exaggerated hypertriglyceridaemia found throughout, in diabetic pregnancy studies by Hollisworth et al and Kokkou et al13 compared to normal pregnancy.…”

Section: Figure 1: Age Distributionmentioning

confidence: 71%

A study of visceral adiposity index as a diagnostic index in gestational diabetes mellitus in a tertiary care centre

Dakshnamurthy

Kasirajan

Nachiyar

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONGestational Diabetes Mellitus (GDM) affects up to 15% of pregnant women worldwide and an estimated 4 million women in India.1 Early detection and initiation of treatment reduces adverse maternal and foetal outcomes. Most of the pregnancies that develop GDM is associated with dyslipidemia, the assessment of which in the 2nd trimester could serve as a potential diagnostic tool. Pregnant women destined to develop GDM had higher total cholesterol, LDL, triglycerides, CRP, and t-PA but ABSTRACTBackground: Gestational Diabetes Mellitus is an emerging problem which affects pregnant women all over the world particularly in India. Early detection reduces adverse maternal and foetal outcome. Elevated central adiposity is a modifiable risk factor for abnormal glucose homeostasis in pregnancy and GDM. The Visceral Adiposity Index (VAI) is a gender-specific index of fat distribution and assessment. Methods: It is a hospital based, case control study among the subjects who attended a tertiary care centre. cases were 30 pregnant women newly diagnosed with GDM in their 2nd trimester, and Controls were 30 apparently healthy pregnant women in their 2nd trimester without risk factors for GDM such as obesity and family history for diabetes. Visceral Adiposity Index (VAI) was calculated using the formula (Waist circumference (WC)/ {36.58 +(1.89xBMI)}) x(TGL/0.81) x (1.52/HDL) where WC is expressed in cm, BMI in Kg/m2, TG in mmol/L, HDL in mmol/L. Results: The mean age of patients with GDM was higher when compared to controls (28.17 ± 3.34vs 24.40±3.07) and this difference was statistically significant (p value < 0.0001). The average weights were significantly different. The mean Body Mass Index (BMI) and waist circumference (WC) was 23.59 ± 4.19 and 88.46 ± 7.10 respectively among controls and 29.85 ±4.52 and 102.12 ± 6.96 respectively among GDM patients and these differences were highly significant (p value<0.0001). The lipid profile of these patients showed a significantly higher value of Triglycerides among patients. Conclusions:This study correlates GDM with Visceral adiposity index and found that the index to be elevated in the GDM group. The increased VAI in GDM patients shows their elevated adipose tissue distribution. VAI is less invasive and cost effective, can be used as a diagnostic index in GDM.

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“…34, 137-138 (2017) We read with interest the paper by Achong et al [1] describing the use of continuous glucose monitoring (CGM) to examine glycaemic patterns in breastfeeding women with Type 1 diabetes. We undertook a similar study using CGM and home blood glucose monitoring diaries to record glycaemic profiles in the first 4 weeks postpartum, which is when the risk of hypoglycaemia is considered to be greatest [2]. We encountered considerable difficulty both in the recruitment and the retention of participants for our study.…”

Section: Competing Interestsmentioning

confidence: 99%

First‐trimester maternal abdominal adiposity and adiponectin in pregnancy

et al. 2016

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Adiponectin, an adipokine derived exclusively from adipose tissue, is linked to the development of dysmetabolism and gestational diabetes mellitus [1]. We examined whether first-trimester subcutaneous, visceral and total adipose tissue depth were associated with hypoadiponectinaemia (low adiponectin) in mid-pregnancy, well before the time of conventional screening for gestational diabetes.Eligible participants were aged ≥18 years with a viable singleton pregnancy at 11-14 weeks' gestation, and without prepregnancy Type 2 diabetes or previous gestational diabetes. The women were followed prospectively at a general obstetrics outpatient clinic at St Michael's Hospital in Toronto, Ontario, where institutional research ethics board approval was obtained. Adiponectin and beta cell dysfunction in gestational diabetes: pathophysiological implications. Diabetologia 2005; 48: 993-1001 5. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun

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Abdominal Adiposity and Insulin Resistance in Early Pregnancy

Cited by 35 publications

References 33 publications

Maternal Subcutaneous and Visceral Adipose Ultrasound Thickness in Women with Gestational Diabetes Mellitus at 24-28 Weeks' Gestation

Maternal Subcutaneous and Visceral Adipose Ultrasound Thickness in Women with Gestational Diabetes Mellitus at 24-28 Weeks' Gestation

A study of visceral adiposity index as a diagnostic index in gestational diabetes mellitus in a tertiary care centre

First‐trimester maternal abdominal adiposity and adiponectin in pregnancy

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