Burden of chronic obstructive pulmonary disease: Healthcare costs and beyond

May, Sara M.; Li, James T.C.

doi:10.2500/aap.2015.36.3812

Cited by 175 publications

(129 citation statements)

References 62 publications

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“…In the US alone it is estimated that the direct and indirect healthcare expenditure of COPD will be $50 billion . In spite of the expected increase in prevalence of chronic lung disease, there are currently no cures–only symptomatic therapies and lung transplantation for end‐stage disease patients …”

Section: Introductionmentioning

confidence: 99%

Evolution of Bioengineered Lung Models: Recent Advances and Challenges in Tissue Mimicry for Studying the Role of Mechanical Forces in Cell Biology

Doryab

Taş

Taskin

et al. 2019

Adv Funct Materials

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Mechanical stretch under both physiological (breathing) and pathophysiological (ventilator-induced) conditions is known to significantly impact all cellular compartments in the lung, thereby playing a pivotal role in lung growth, regeneration and disease development. In order to evaluate the impact of mechanical forces on the cellular level, in vitro models using lung cells on stretchable membranes have been developed. Only recently have some of these cell-stretching devices become suitable for air-liquid interface cell cultures, which is required to adequately model physiological conditions for the alveolar epithelium. To reach this goal, a multi-functional membrane for cell growth balancing biophysical and mechanical properties is critical to mimic (patho)physiological conditions. In this review, i) the relevance of cyclic mechanical forces in lung biology is elucidated, ii) the physiological range for the key parameters of tissue stretch in the lung is described, and iii) the currently available in vitro cell-stretching devices are discussed. After assessing various polymers, it is concluded that natural-synthetic copolymers are promising candidates for suitable stretchable membranes used in cell-stretching models. This work provides guidance on future developments in biomimetic in vitro models of the lung with the potential to function as a template for other organ models (e.g., skin, vessels).

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Section: Introductionmentioning

confidence: 99%

Evolution of Bioengineered Lung Models: Recent Advances and Challenges in Tissue Mimicry for Studying the Role of Mechanical Forces in Cell Biology

Doryab

Taş

Taskin

et al. 2019

Adv Funct Materials

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show abstract

“…Due to smoking and increasing air pollution the current prevalence of 10.1% is estimated to further increase in the next decades (Celli and Wedzicha, 2019). Considering the enormous medical and financial burden of COPD (May and Li, 2015;Patel et al, 2018), there is a need to develop efficient biomarker-based diagnostics, and molecularly defined therapies.…”

Section: Introductionmentioning

confidence: 99%

Alterations of multiple alveolar macrophage states in chronic obstructive pulmonary disease

Baßler

Fujii

Kapellos

et al. 2020

Preprint

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Despite the epidemics of chronic obstructive pulmonary disease (COPD), the cellular and molecular mechanisms of this disease are far from being understood. Here, we characterize and classify the cellular composition within the alveolar space and peripheral blood of COPD patients and control donors using a clinically applicable single-cell RNA-seq technology corroborated by advanced computational approaches for: machine learning-based cell-type classification, identification of differentially expressed genes, prediction of metabolic changes, and modeling of cellular trajectories within a patient cohort. These high-resolution approaches revealed: massive transcriptional plasticity of macrophages in the alveolar space with increased levels of invading and proliferating cells, loss of MHC expression, reduced cellular motility, altered lipid metabolism, and a metabolic shift reminiscent of mitochondrial dysfunction in COPD patients. Collectively, single-cell omics of multi-tissue samples was used to build the first cellular and molecular framework for COPD pathophysiology as a prerequisite to develop molecular biomarkers and causal therapies against this deadly disease.

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“…COPD is a debilitating condition affecting millions of people worldwide and is the leading cause of chronic morbidity and mortality in patients with lung disease . Tobacco smoking and atmospheric pollution are the main risk factors for the development of COPD . It is characterized by excess mucus production and small airway destruction, causing reduced lung compliance.…”

Section: Metabolomic‐driven Discovery Of Biomarkersmentioning

confidence: 99%

Metabolomics in chronic lung diseases

et al. 2019

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Chronic lung diseases represent a significant global burden. Their increasing incidence and complexity render a comprehensive, multidisciplinary and personalized approach to each patient, critically important. Most recently, unique biochemical pathways and disease markers have been identified through large‐scale metabolomic studies. Metabolomics is the study of metabolic pathways and the measurement of unique biomolecules in a living system. Analysing samples from different compartments such as bronchoalveolar lavage fluid (BALF) and plasma has proven useful for the characterization of a number of pathological conditions and offers promise as a clinical tool. For example, several studies using mass spectrometry (MS) have shown alterations in the sphingolipid metabolism of chronic obstructive pulmonary disease (COPD) sufferers. In this article, we present a practical review of the application of metabolomics to the study of chronic lung diseases (CLD): COPD, idiopathic pulmonary fibrosis (IPF) and asthma. The insights, which the analytical strategies employed in metabolomics, have provided to the dissection of the biochemistry of CLD and future clinical biomarkers are explored.

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Burden of chronic obstructive pulmonary disease: Healthcare costs and beyond

Abstract: Chronic

Cited by 175 publications

References 62 publications

Evolution of Bioengineered Lung Models: Recent Advances and Challenges in Tissue Mimicry for Studying the Role of Mechanical Forces in Cell Biology

Evolution of Bioengineered Lung Models: Recent Advances and Challenges in Tissue Mimicry for Studying the Role of Mechanical Forces in Cell Biology

Alterations of multiple alveolar macrophage states in chronic obstructive pulmonary disease

Metabolomics in chronic lung diseases

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