Predictive Value of Echocardiographic Parameters for Clinical Events in Patients Starting Hemodialysis

Han, Seung Seok; Cho, Goo Yeong; Park, Youn Su; Baek, Seon Ha; Ahn, Shin Young; Kim, Sejoong; Chin, Ho Jun; Chae, Dong Wan; Na, Ki Young

doi:10.3346/jkms.2015.30.1.44

Cited by 17 publications

(17 citation statements)

References 35 publications

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“…The patients were examined by two cardiologists with the method of conventional M-mode and two-dimensional echocardiography for LVH estimation, systolic and diastolic cardiac function assessment, and consideration of the ischemic findings according to the recommendations of the American Society of Echocardiography [17]. LVH was defined by a thickness of the interventricular septum >11.5 mm.…”

Section: Echocardiographic Assessmentmentioning

confidence: 99%

The Relationship of Residual Renal Function with Cardiovascular Morbidity in Hemodialysis Patients and the Potential Role of Monocyte Chemoattractant Protein-1

Raikou¹,

Kardalinos²,

Kyriaki³

2017

Kidney Dis

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Background: Residual renal function (RRF) provides several benefits to patients on dialysis. Monocyte chemoattractant protein-1 (MCP-1) plays an important role in atherosclerotic lesions. We considered the relationship between RRF and cardiovascular morbidity and the significant role of MCP-1 serum concentrations in hemodiafiltration (HDF) patients. Methods: We enrolled 76 patients on on-line HDF. RRF was defined by interdialytic urine output, and we studied the patients in two groups according to the preservation or not of urine output. MCP-1 levels were measured using enzyme-linked immunosorbent assay. χ² tests were applied for the association between RRF and left ventricular hypertrophy (LVH), coronary artery disease (CAD), peripheral artery disease (PAD), and systolic and diastolic cardiac dysfunction. We built an adjusted model using logistic regression analysis for the factors which might impact on the loss of urine output. Results: χ² tests showed a significant association between the loss of urine output and LVH, diastolic dysfunction, and PAD (χ² = 7.4, p = 0.007; χ² = 14.3, p = 0.001; χ² = 4.2, p = 0.03, respectively), although the association with CAD and systolic dysfunction was found to be nonsignificant. The patients without RRF had significantly higher MCP-1, and the urine volume was inversely associated with MCP-1 (r = -465, p = 0.03). In the built adjusted model, the elevated MCP-1 was found to be a significant predictor for the loss of RRF. Conclusion: The loss of RRF was significantly associated with LVH, diastolic dysfunction, and PAD in HDF patients. The increased MCP-1, affected by the lack of urine, may act as an additional underlying factor on this relationship, reflecting a progressive inflammation/oxidative stress condition.

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Section: Echocardiographic Assessmentmentioning

confidence: 99%

The Relationship of Residual Renal Function with Cardiovascular Morbidity in Hemodialysis Patients and the Potential Role of Monocyte Chemoattractant Protein-1

Raikou¹,

Kardalinos²,

Kyriaki³

2017

Kidney Dis

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“…Cross-section surveys demonstrate that up to 80% of dialysis patients have left ventricular (LV) alterations, among which left ventricular hypertrophy (LVH) is the most frequent finding [3]. LVH is considered a key cardiovascular complication in peritoneal dialysis (PD) patients, with an estimated prevalence ranging from 44 to >90% [4].…”

Section: Introductionmentioning

confidence: 99%

Nonparallel Progression of Left Ventricular Structure and Function in Long-Term Peritoneal Dialysis Patients

et al. 2017

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Background/Aims: Left ventricular hypertrophy and dysfunction are key cardiovascular risk factors of patients on peritoneal dialysis (PD). The purpose of this study was to investigate the dynamic changes of left ventricular (LV) structure and function in patients on long-term PD. Methods: Patients who underwent PD catheter insertions from January 2010 to December 2012 in our PD center were enrolled into this study. Cardiac structure and function of those patients were determined by echocardiography (4 times) at 12-month intervals. Patients' biochemical parameters, body mass index, blood pressure, urine output, ultrafiltration, and total fluid removal volume were collected. The use of antihypertensive drugs and active vitamin D₃ was also recorded. Results: A total of 40 patients were included. After 3 years of follow-up, patients' PD duration time, LV mass/height^2.7 (p = 0.580), interventricular septal thickness (p = 0.216), left ventricular posterior wall thickness (p = 0.216), and LV ejection fraction (p = 0.270) did not show significant changes during the follow-up. In contrast, the E/A ratio (p = 0.004) and e' (p < 0.001) were statistically decreased, and the E/e' ratio (p = 0.006) was increased. Left atrial diameter was increased (p = 0.008), but the changes in left atrial diameter index did not reach statistical significance (p = 0.090). Conclusion: Long-term PD patients maintain stable LV structure and cardiac systolic function, but cardiac diastolic function declines over time.

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“…Prognostický význam: Dlouhodobě zvýšené plnicí tlaky podle některých autorů [22] nepříznivě ovlivňují výskyt kardiovaskulárních komplikací i mortalitu.…”

Section: Diastolická Dysfunkce Levé Komoryunclassified

Echocardiography in patients with chronic kidney diseases

Malík¹,

Danzig²,

Bednářová³

et al. 2018

Cor Vasa

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Většina pacientů s chronickým onemocněním ledvin umírá na kardiovaskulární komplikace. Echokardiografi e je základní metoda k odhalení většiny z nich. Zahrnují především dilataci a dysfunkce levé komory i levé síně, hypertrofi i levé komory, diastolickou dysfunkci levé komory, kalcifi kační postižení srdce, které může vést až k rozvoji stenotických vad, dysfunkci pravé komory a plicní hypertenzi. Zvláštností pacientů s chronickým selháním ledvin je cyklicky se měnící stav hydratace a přítomnost nízkoodporového dialyzačního zkratu (přístupu pro hemodialýzu). Tyto faktory zásadně ovlivňují aktuální echokardiografi cký nález.

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Predictive Value of Echocardiographic Parameters for Clinical Events in Patients Starting Hemodialysis

Cited by 17 publications

References 35 publications

The Relationship of Residual Renal Function with Cardiovascular Morbidity in Hemodialysis Patients and the Potential Role of Monocyte Chemoattractant Protein-1

The Relationship of Residual Renal Function with Cardiovascular Morbidity in Hemodialysis Patients and the Potential Role of Monocyte Chemoattractant Protein-1

Nonparallel Progression of Left Ventricular Structure and Function in Long-Term Peritoneal Dialysis Patients

Echocardiography in patients with chronic kidney diseases

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