Does the Use of Chitosan Contribute to Oxalate Kidney  Stone Formation?

Queiroz, Moacir Fernandes; Melo, Karoline Rachel Teodosio; Sabry, Diego Araújo; Sassaki, Guilherme L.; Rocha, Hugo Alexandre Oliveira

doi:10.3390/md13010141

Cited by 796 publications

(386 citation statements)

References 45 publications

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“…[31]. The peak in the region of 2870 cm −1 is assigned to the C-H stretching [31,32]. Expectedly, the N-H and C-N peaks are observed at around 1600 and 1500 cm −1 , respectively.…”

Section: Physical Appearance Of Synthesized Agnps/chitosan Nanofluidsmentioning

confidence: 94%

Preparation of Silver/Chitosan Nanofluids Using Selected Plant Extracts: Characterization and Antimicrobial Studies against Gram-Positive and Gram-Negative Bacteria

et al. 2020

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Chitosan/silver nanofluids were prepared using Phoenix dactylifera (DPLE) or Rumex vesicarius (HEL) extracts as the reducing agent, characterized using Fourier-transform infrared spectroscopy (FTIR), ultraviolet–visible (UV-vis), X-ray diffraction (XRD), and transmission electron microscope (TEM). The antimicrobial effect of the nanofluids against Gram positive, Bacillus licheniformis, Staphylococcus haemolyticus, Bacillus cereus, and Micrococcus luteus, and Gram-negative Pseudomonas aeruginosa, Pseudomonas citronellolis, and Escherichia coli bacteria has been studied. The nanoparticles were polydispersed in the chitosan matrix and are highly stable. The zeta potential of the silver nanoparticles in DPLE- and HEL-mediated composites is +46 mV and +56 mV, respectively. The FTIR results reveal that the free carboxylate groups in the plant biomaterial took part in stabilization process. HEL is a stronger reducing agent than DPLE and nanoparticles generated with HEL are smaller (8.0–36 nm) than those produced with DPLE (10–43 nm). DPLE- and HEL-mediated composites effectively inhibit the growth of the studied bacteria but HEL-mediated composite exhibited higher effect. The higher antimicrobial activity of HEL-mediated composite is linked to the smaller nanoparticles. The foregoing results indicate that HEL extract can be used in the green production of potential antimicrobial chitosan/silver nanofluids for biomedical and packaging applications.

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“…[31]. The peak in the region of 2870 cm −1 is assigned to the C-H stretching [31,32]. Expectedly, the N-H and C-N peaks are observed at around 1600 and 1500 cm −1 , respectively.…”

Section: Physical Appearance Of Synthesized Agnps/chitosan Nanofluidsmentioning

confidence: 94%

Preparation of Silver/Chitosan Nanofluids Using Selected Plant Extracts: Characterization and Antimicrobial Studies against Gram-Positive and Gram-Negative Bacteria

et al. 2020

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“…The absorption peaks observed between 2923 and 2810 cm −1 are assigned to the vibrational modes of C─H groups in the FTIR spectrum of native chitosan. These bands are characteristics of polysaccharide and are found in other polysaccharide spectra . In the FTIR spectrum of native acacia gum, the bands at 2923 cm −1 represent the existence of alkane and aldehyde C─H stretch.…”

Section: Resultsmentioning

confidence: 90%

ZnO microparticle‐loaded chitosan/poly(vinyl alcohol)/acacia gum nanosphere‐based nanocomposite thin film wound dressings for accelerated wound healing

Güldiken

Karaosmanoğlu

Sivas

et al. 2019

J of Applied Polymer Sci

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The present study deals with the development of novel ZnO microparticle‐loaded chitosan/poly(vinyl alcohol)/acacia gum nanosphere‐based nanocomposite thin films through electrospraying and evaluation of their potential use in wound healing applications for skin. ZnO microparticles were synthesized and used as bioactive agents. Morphology, size distribution, structure, and dispersion of the synthesized ZnO microparticles were analyzed by scanning electron microscopy (SEM), energy‐dispersive X‐ray spectroscopy, Fourier transform infrared spectroscopy, and transmission electron microscopy (TEM). ZnO microparticles were incorporated into the ternary nanocomposite films by electrospraying technique. Thermogravimetric analyses reveal that incorporation of ZnO microparticles into the nanocomposite structure improves the thermal stability. Mechanical analyses show that tensile strength reaches to the maximum value of 12.75 MPa with 0.6 wt % ZnO content. SEM and TEM micrographs demonstrate that the nanocomposite films consist of nanospheres with nanocapsular structures whose sizes are mostly between 250 and 550 nm. Viability tests established prevailing cellular performance of the fibroblasts on 0.6 wt % ZnO microparticle‐loaded nanocomposite films with a viability percentage of 160% compared to the control group. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48445.

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“…); IR (KBr): 3355 cm −1 (-OH) P1 , 2863 cm −1 (-CH-) P2 , 1645 cm −1 (-CO-NH-) P3 1575 cm −1 (-NH 2 ) P4 , 1150 cm −1 (-C-O-C-) P5 , 1026 cm −1 (-C-O-) P6 and 891 (pyranoid ring) P7 (Fig. 3A-CHI) 17,30,31 (Fig. S1E,f, S.I.…”

Section: Characterization and Detailed Spectral Data Of The Pnsc Syntmentioning

confidence: 99%

Photosensitive nanocarriers for specific delivery of cargo into cells

Mena-Giraldo

Pérez-Buitrago

Londoño-Berrio

et al. 2020

Sci Rep

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Nanoencapsulation is a rapidly expanding technology to enclose cargo into inert material at the nanoscale size, which protects cargo from degradation, improves bioavailability and allows for controlled release. Encapsulation of drugs into functional nanocarriers enhances their specificity, targeting ability, efficiency, and effectiveness. Functionality may come from cell targeting biomolecules that direct nanocarriers to a specific cell or tissue. Delivery is usually mediated by diffusion and erosion mechanisms, but in some cases, this is not sufficient to reach the expected therapeutic effects. This work reports on the development of a new photoresponsive polymeric nanocarrier (PNc)-based nanobioconjugate (NBc) for specific photo-delivery of cargo into target cells. We readily synthesized the PNcs by modification of chitosan with ultraviolet (UV)-photosensitive azobenzene molecules, with Nile red and dofetilide as cargo models to prove the encapsulation/release concept. The PNcs were further functionalized with the cardiac targeting transmembrane peptide and efficiently internalized into cardiomyocytes, as a cell line model. Intracellular cargo-release was dramatically accelerated upon a very short UV-light irradiation time. Delivering cargo in a time-space controlled fashion by means of NBcs is a promising strategy to increase the intracellular cargo concentration, to decrease dose and cargo side effects, thereby improving the effectiveness of a therapeutic regime. Functional nanocarriers for intracellular drug delivery are systems ideally composed of biodegradable and biocompatible materials such as natural polymers, lipids, amphiphilic polymers, among others, assembled with cell-targeting biomolecules (CTBs) 1,2. Nanocarriers can be designed for transporting a variety of cargo, either encapsulated into, adsorbed at, or dispersed with the nanocarriers 3. Encapsulation of therapeutic agents into nanocarriers protects them from degradation, improves their solubility and bioavailability, and enhances the efficiency and effectiveness of therapeutic regimens. However, nanocarrier systems have shown some limitations related to storage stability and administration route, because they are susceptible to aggregation and early degradation 4. Biodistribution may be also unspecific, generating inefficient therapies, side effects, genetic damage or mutations. To solve these issues, apart from carboxylic, amino, poly(ethylene glycol) and poly(phosphoester) moieties that can be placed at the outermost nanocarrier surface to confer a stealth effect, they can be functionalized with specific CTBs for site-specific controlled cargo release 5-7. Targeting ability and specificity of the resultant NBcs allows them to accumulate in the target cell or tissue at higher concentrations compared to nanoparticles without activity, thus reducing doses, frequency, toxicity and potential adverse effects that most drugs intrinsically have 8,9. Whereas the small size of NBcs, which are commonly less than 200 nm for biomedical applications 10,1...

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Does the Use of Chitosan Contribute to Oxalate Kidney Stone Formation?

Cited by 796 publications

References 45 publications

Preparation of Silver/Chitosan Nanofluids Using Selected Plant Extracts: Characterization and Antimicrobial Studies against Gram-Positive and Gram-Negative Bacteria

Preparation of Silver/Chitosan Nanofluids Using Selected Plant Extracts: Characterization and Antimicrobial Studies against Gram-Positive and Gram-Negative Bacteria

ZnO microparticle‐loaded chitosan/poly(vinyl alcohol)/acacia gum nanosphere‐based nanocomposite thin film wound dressings for accelerated wound healing

Photosensitive nanocarriers for specific delivery of cargo into cells

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