“…In fact, existing evidence indicates that EE attenuates the chronic stress impact on behavior and hippocampal integrity, thus protecting against the stress-associated cognitive deficits, emotional dysregulation, dendritic atrophy and reduced neurogenesis (Hutchinson et al, 2012;Veena et al, 2009;Wright and Conrad, 2008). Similar to adult stress, restorative effects of EE have been reported in rodents submitted to prenatal (Laviola et al, 2008;Pascual et al, 2015;Yang et al, 2007) or juvenile stress (Ilin and Richter-Levin, 2009). To the best of our knowledge, there is limited information regarding the compensatory action of EE following early stress (do Prado et al, 2016;Francis et al, 2002;Koe et al, 2016;Vivinetto et al, 2013) and so far, no study has looked at the interaction of maternal separation and subsequent exposure to EE conditions concurrently at cognitive and emotional behavior, HPA function and markers of synaptic plasticity (BDNF, SYN) during adulthood.…”