Postpartum adiponectin changes in women with gestational diabetes

Martyjaszek-Matuszek, B.; Lenart-Lipińska, Monika; Kowalczyk-Bołtuć, Jolanta; Wozniak, Slawomir; Paszkowski, Tomasz

doi:10.5604/12321966.1129945

Cited by 9 publications

(8 citation statements)

References 26 publications

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“…The majority of studies have performed this assessment in the early postpartum period (1–14 days after delivery) and observed a tendency of decrease in adiponectin concentrations from pregnancy to that time point [ 6 – 9 ]. In turn, some studies performed this assessment during the late postpartum period (3–12 months after delivery) and reported higher concentrations of adiponectin than during pregnancy, which is consistent with our findings [ 10 – 12 ]. The findings of lower adiponectin concentrations in the early postpartum period and higher adiponectin concentrations in the late postpartum period is logical and is supported by two other previous findings: adiponectin concentrations tend to decrease during pregnancy [ 7 , 28 ] and delivery is an inflammatory process, independently of the mode of delivery [ 29 ].…”

Section: Discussionsupporting

confidence: 92%

Changes in Maternal Plasma Adiponectin from Late Pregnancy to the Postpartum Period According to the Mode of Delivery: Results from a Prospective Cohort in Rio de Janeiro, Brazil

Rebelo

Franco‐Sena²,

Struchiner

et al. 2016

PLoS ONE

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IntroductionMaternal plasma adiponectin is inversely related to insulin resistance, atherosclerosis and child health. However, little is known about its concentrations in the perinatal period, especially according to mode of delivery. Our aim is to evaluate the association between mode of delivery and changes in maternal plasma adiponectin from 3rd trimester of pregnancy to 30–45 days postpartum.MethodsA cohort was recruited in Rio de Janeiro, Brazil, with four waves of follow-up: 5-13th, 22-26th, 30-36th gestational weeks and 30–45 days postpartum. Eligible subjects should be between 20–40 years of age, be free of chronic and infectious diseases and presenting with a singleton pregnancy. The mode of delivery was classified as vaginal (VD) or cesarean (CS). Plasma adiponectin concentration (μg/mL) was measured using commercial ELISA kits. Statistical analyses included the Wilcoxon rank-sum test and the multiple linear mixed effects model.ResultsA total of 159 participated in the study. Median adiponectin concentrations were higher for the VD group (n = 99; 8.25, IQR: 5.85–11.90) than for the CS group (n = 60; 7.34, IQR: 4.36–9.76; p = 0.040) in the postpartum samples but were not different between the two groups in the 3rd trimester. Women who underwent CS had a lower rate of increase in adiponectin concentration from the 3rd trimester to 30–45 days postpartum compared to those who underwent VD (β = -.15, 95% CI: -.28-.02, p = 0.030).ConclusionThe CS procedure was associated with lower maternal circulating concentrations of adiponectin at 30–45 days postpartum, compared to the VD.

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Section: Discussionsupporting

confidence: 92%

Changes in Maternal Plasma Adiponectin from Late Pregnancy to the Postpartum Period According to the Mode of Delivery: Results from a Prospective Cohort in Rio de Janeiro, Brazil

Rebelo

Franco‐Sena²,

Struchiner

et al. 2016

PLoS ONE

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“…In the present study, the overall proportion of PPD was found to be 27% at six week postpartum. Findings from other community and hospital based studies in South India, reflect variability in the estimates of PPD with the reported prevalence of 18.6% and 13.8% [ 4 , 33 ]. In our present study, we found that more women in the depressed group were employed and most of the women with depression reported marital disharmony and lack of support from the husband as shown in S1 Table .…”

Section: Discussionmentioning

confidence: 73%

Low serum levels of High-Density Lipoprotein cholesterol (HDL-c) as an indicator for the development of severe postpartum depressive symptoms

et al. 2018

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Postpartum depression (PPD) is a psychiatric complication of childbirth affecting 10–20% of new mothers and has negative impact on both mother and infant. Serum lipid levels have been related to depressive disorders, but very limited literatures are available regarding the lipid levels in women with postpartum depression. The present study is aimed to examine the association of serum lipids with the development of postpartum depressive symptoms. This is a cross sectional study conducted at a tertiary care hospital in South India. Women who came for postpartum check-up at 6th week post-delivery were screened for PPD (September 2014-October 2015). Women with depressive symptoms were assessed using EPDS (Edinburgh Postnatal Depression Scale). The study involved 186 cases and 250 controls matched for age and BMI. Serum levels of lipid parameters were estimated through spectrophotometry and the atherogenic indices were calculated in all the subjects. Low serum levels of Total Cholesterol (TC) and High Density Lipoprotein cholesterol (HDL-c) were significantly low in PPD women with severe depressive symptoms. The study recorded a significant negative correlation between HDL-c and the EPDS score in PPD women (r = -0.140, p = 0.05). Interestingly, the study also observed a significant negative correlation between Body Mass Index (BMI) and EPDS scores in case group (r = -0.146, p = 0.047), whereas a positive correlation between the same in controls (r = 0.187, p = 0.004). Our study demonstrated that low levels of serum HDL-c is correlated with the development of severe depressive symptoms in postpartum women. Study highlights the role of lipids in the development of postpartum depressive symptoms.

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“…The measurement of plasma TSH is the most widely used and sensitive screening test for primary thyroid disorders. This is because even slight changes in the levels of free thyroid hormones can cause signi cant changes in the secretion of the pituitary gland (10). There are several methods to determine the levels of TSH in the serum or plasma.…”

Section: Discussionmentioning

confidence: 99%

Anti Thyroglobulin Interferences in TSH Measurement, A Case Report

Bakhtiari

2024

Preprint

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Thyroglobulin (Tg) is the most expressed protein in the thyroid gland that stores iodine and produces thyroid hormones. Tg production is specific to malignant thyroid cells, making it an ideal indicator after removing thyroid tissue. As a result, it is used as a tumor marker post-surgery to assess any disease recurrence. The presence of Thyroglobulin antibody (TgAb) which is produced in autoimmune diseases can interfere with Tg value. The evaluation of plasma TSH levels is a highly sensitive diagnostic method for primary thyroid-related issues, although it can be affected by various interferences. in the present case, the high titer of TgAb interferes with TSH measurement as well as leads to unreliable Tg results.

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Postpartum adiponectin changes in women with gestational diabetes

Cited by 9 publications

References 26 publications

Changes in Maternal Plasma Adiponectin from Late Pregnancy to the Postpartum Period According to the Mode of Delivery: Results from a Prospective Cohort in Rio de Janeiro, Brazil

Changes in Maternal Plasma Adiponectin from Late Pregnancy to the Postpartum Period According to the Mode of Delivery: Results from a Prospective Cohort in Rio de Janeiro, Brazil

Low serum levels of High-Density Lipoprotein cholesterol (HDL-c) as an indicator for the development of severe postpartum depressive symptoms

Anti Thyroglobulin Interferences in TSH Measurement, A Case Report

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