Is the use of negative pressure wound therapy for a malignant wound legitimate in a palliative context? “The concept of NPWT <i>ad vitam</i>”: A case series

Riot, Samuel; Bonnecaze, Guillaume de; Garrido, I.; Ferron, Gwénaël; Grolleau, J.-L.; Chaput, Benoît

doi:10.1177/0269216314560009

Cited by 32 publications

(34 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…NPWT successfully controlled the odour and obviated the need for frequent painful dressing changes. A subsequent case series validated the use of NPWT in this clinical scenario and concluded that its application results in improved quality of life and earlier discharge to home .…”

Section: Discussionmentioning

confidence: 86%

Use of negative pressure wound therapy on malignant wounds – a case report and review of literature

Cai

Gowda

Alexander

et al. 2016

International Wound Journal

View full text Add to dashboard Cite

The presence of malignancy is considered a contraindication to the use of negative pressure wound therapy (NPWT) because of concerns that it may promote tumourigenesis and expedite metastasis. This notion is extrapolated from studies evaluating NPWT in normal tissues. Despite the absence of direct evidence, the use of this technology in malignant wounds is widely considered a contraindication. We present the case of a patient with treatment-resistant metastatic colon cancer, who developed a chronic abdominal wound with positive margins. A staged reconstruction using NPWT was performed and wound closure allowed the patient to meet eligibility criteria and enrol in a clinical trial for treatment of his oncological disease. Skin closure remained intact until the patient expired 6 months after the wound closure. This case, as well as others in the literature, demonstrated that the use of NPWT should not be considered an absolute contraindication in malignancy. Individualised approaches taking into account the patient's clinical scenario, the available evidence, as well as the risks and benefits of this technology are recommended.

show abstract

Section: Discussionmentioning

confidence: 86%

Use of negative pressure wound therapy on malignant wounds – a case report and review of literature

Cai

Gowda

Alexander

et al. 2016

International Wound Journal

View full text Add to dashboard Cite

show abstract

“…The effect of NPWT in the presence of malignancy is not known. Many human health authorities and manufacturers have contraindicated its use for malignant wounds because of its theoretical potential to promote tumour growth . To our knowledge there are no data in the existing literature to address this concern .…”

Section: Discussionmentioning

confidence: 99%

“…All patients received perioperative cephazolin (22 mg/kg IV; Cephazolin-AFT, AFT Pharmaceuticals, NSW, Aust) followed by cephalexin (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)…”

Section: Postoperative Carementioning

confidence: 99%

Negative pressure wound therapy using a portable single‐use device for free skin grafts on the distal extremity in seven dogs

Aj¹,

Cashmore²,

Marchevsky³

et al. 2016

Aust Veterinary J

View full text Add to dashboard Cite

show abstract

“…the sarcomas, the parietal recurrence of the breast carcinoma, the head melanoma described by Riot), which had good results as a palliative treatment in those cases. 4 Heller had introduced vaccum assisted therapy as a preparation for brachytherapy of patients with sarcoma. 5 …”

Section: Discussionmentioning

confidence: 99%

“…2 There are only few contraindications for the negative pressure wound therapy use (e.g. an active malignant process, 3 however, it is reported that in some cases it has achieved positive effects [4][5][6][7][8][9][10] ).…”

Section: Introductionmentioning

confidence: 99%

Negative pressure wound therapy use in the treatment of patient with an active process of anal cancer in order to the further treatment – case report.

Kicińska

Błażejewska

Banasiewicz

2016

NPWTJ

View full text Add to dashboard Cite

Abstract-Anal cancer occurs very rare in our population. Its treatment depends on the advancement of the process. Occasionally, the lesions are removed surgically, but most of advanced lesions are treated by radiotherapy and chemotherapy, also combined with surgical removal. Sometimes the combination therapy is difficult to perform, in cases when there is no possibility to protect the bowels against the direct side effects of radiotherapy due to wide excision. In most complicated and non-healing wounds, negative pressure therapy significantly improves the treatment results. This kind of treatment has also its restrictions: main contraindication is an active malignant process, however, it is reported that in some cases it has achieved positive effects.68 years-old man was admitted to the Proctological Outpatient Office because of perianal genital warts. Histological examination diagnosed them as condylomata acuminata but when the patient reported back to the same Outpatient Office after 2 years, he presented with a giant perianal tumor. Because of severe problems with passing stool, size of the lesions, sphincter infiltration and its full dysfunction, abdominoperineal rectal resection with end colostomy was performed. In the histological examination anal cancer was recognized: stage IIIA: T3N1M0 and further radiotherapy and chemotherapy were indicated. An open, nonhealing wound was a contraindication for radiotherapy. Despite the potential malignancy in the wound, the negative pressure wound therapy (with the continuous pressure -100 mmHg) was introduced. After 20 days of treatment, the wound was closed by granulation. Patient was qualified to the radiation therapy (60 Gy) combined with 5-FU and Mitomycin C, with good results.In our case, applying negative pressure wound therapy resulted in wound closing and allowed to introduce the main way of healing -radiotherapy, suggesting that NPWT can be used as supportive management of neoplastic diseases.

show abstract

Is the use of negative pressure wound therapy for a malignant wound legitimate in a palliative context? “The concept of NPWT ad vitam”: A case series

Cited by 32 publications

References 7 publications

Use of negative pressure wound therapy on malignant wounds – a case report and review of literature

Use of negative pressure wound therapy on malignant wounds – a case report and review of literature

Negative pressure wound therapy using a portable single‐use device for free skin grafts on the distal extremity in seven dogs

Negative pressure wound therapy use in the treatment of patient with an active process of anal cancer in order to the further treatment – case report.

Contact Info

Product

Resources

About