High-Density Lipoprotein: Structural and Functional Changes Under Uremic Conditions and the Therapeutic Consequences

Schuchardt, Mirjam; Tölle, Markus; Giet, Markus van der

doi:10.1007/978-3-319-09665-0_13

Cited by 9 publications

(5 citation statements)

References 152 publications

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“…It was also reported that a higher HDL-C level was not associated with a reduced mortality risk and CAD severity in patients with reduced kidney function [23]. Furthermore, patients with CKD were reported to show changes in the composition of and decreased protective function of HDL-C [24]. The vascular effects of HDL-C in patients with DKD might differ from those in normal patients.…”

Section: Discussionmentioning

confidence: 99%

Relationship between kidney function decline and initial risk factors for the progression of diabetic kidney disease: a retrospective analysis of 91 Japanese patients with type 2 diabetes

Ishizuka

Tokuyama²,

Horie

et al. 2016

Diabetol Int

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Background Diabetic kidney disease (DKD) is the leading cause of end-stage renal disease (ESRD) in Japan. The clinical course and factors related to the progression of DKD to ESRD are important issues when treating patients with DKD. Methods Ninety-one type 2 diabetic patients with DKD that had progressed from chronic kidney disease (CKD) stages G1-3 on their initial clinical visit to ESRD were enrolled. The decline in the estimated glomerular filtration rate (eGFR) was analyzed and the initial clinical factors that influenced the decline rate were explored. Results There was a linear decline in eGFR before progression to ESRD, with a median annual decline rate (DeGFR) of 9.2 mL/min/1.73 m 2 . In all patients, a history of coronary artery disease and increased levels of initial eGFR and high-density lipoprotein cholesterol (HDL-C) were positive predictors of log DeGFR, whereas age, history of cerebral infarction (CI), and an increased level of serum albumin were negative predictors of log DeGFR. In patients with CKD stages G1-2 on their first visit, male sex and increased diastolic blood pressure were positive predictors. In patients with CKD stage G3 on their first visit, an increased level of LDL-C was a positive predictor, whereas a history of CI and an increased level of serum total bilirubin (TBil) were negative predictors. Conclusion In addition to the common risk factors, initial eGFR, HDL-C, and TBil were identified as novel risk factors for ESRD. These risk factors may differ between patients with early and advanced stages of CKD.

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Section: Discussionmentioning

confidence: 99%

Relationship between kidney function decline and initial risk factors for the progression of diabetic kidney disease: a retrospective analysis of 91 Japanese patients with type 2 diabetes

Ishizuka

Tokuyama²,

Horie

et al. 2016

Diabetol Int

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“…Increase in cholesteryl ester transfer protein (CETP) and decreased lecithin-cholesterol acyltransferase (LCAT) activity contributes to decreased HDL-cholesterol levels. (Schuchardt et al, 2015). Beyond reduced HDL cholesterol levels, the HDL in CKD is less effective in its anti-oxidative and anti-inflammatory functions.…”

Section: Hyperlipidemiamentioning

confidence: 99%

Cerebro‐renal interaction and stroke

Shah

Jagtap

Sarmah

et al. 2020

Eur J of Neuroscience

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Stroke is an event causing a disturbance in cerebral function leading to death and disability worldwide. Both acute kidney injury and chronic kidney disease (CKD) are associated with an increased risk of stroke and cerebrovascular events. The underlying mechanistic approach between impaired renal function and stroke is limitedly explored and has attracted researchers to learn more for developing therapeutic intervention. Common risk factors such as hypertension, hyperphosphatemia, atrial fibrillation, arteriosclerosis, hyperhomocysteinemia, blood-brain barrier disruption, inflammation, etc. are observed in the general population, but are high in renal failure patients. Also, risk factors like bone mineral metabolism, uremic toxins, and anemia, along with the process of dialysis in CKD patients, eventually increases the risk of stroke. Therefore, early detection of risks associated with stroke in CKD is imperative, which may decrease the mortality associated with it. This review highlights mechanisms by which kidney dysfunction can lead to cerebrovascular events and increase the risk of stroke in renal impairment.

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“…46 Reduced activity of lecithincholesterol acyltransferase and elevated protein transfer cholesterol esterol (CETP) event lead to reduced levels of HDL cholesterol. [47] Statins are the frequently used lipid-lowering drugs are listed in (Table 2).…”

Section: Cardiovascular Riskmentioning

confidence: 99%

An overview on Chronic Kidney Disease allied risk factors and complications

Akhila¹,

B²,

Eega³

et al. 2020

Int J Res Pharm Hos & Clin. Pharm

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Chronic kidney disease is a long term condition characterized by the gradual loss of kidney function at least a period of 3 months or more. About two-thirds of the cases are mainly caused due to HTN and DM. The symptom load plays a crucial role in the patient's disease experience and among the main signs of CKD are troubling physical and psychological symptoms. The evaluation of the symptom burden of CKD patients is of the utmost importance in clinical management. The risk factors include age, sex, race and ethnicity, family history, drug use, smoking, and socioeconomic status; and other comorbidities, such as hypertension and diabetes. Some risk factors can be modified and prevent or slow down the progression to ESRD. CKD progression is associated with serious complications such as cardiovascular risk, dyslipidemia, anemia, nutritional issues, and mineral and bone disorders.

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High-Density Lipoprotein: Structural and Functional Changes Under Uremic Conditions and the Therapeutic Consequences

Cited by 9 publications

References 152 publications

Relationship between kidney function decline and initial risk factors for the progression of diabetic kidney disease: a retrospective analysis of 91 Japanese patients with type 2 diabetes

Relationship between kidney function decline and initial risk factors for the progression of diabetic kidney disease: a retrospective analysis of 91 Japanese patients with type 2 diabetes

Cerebro‐renal interaction and stroke

An overview on Chronic Kidney Disease allied risk factors and complications

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