Preparation and characterization of gatifloxacin-loaded alginate/poly (vinyl alcohol) electrospun nanofibers

Abstract

The aim of this study was to develop novel biomedicated electrospun nanofibers for controlled release. Pre-formulation studies were carried out for nanofibers of sodium alginate (SA) (2 wt %)/polyvinyl alcohol (PVA) (10 wt %) composites (2/8, 3/7 and 4/6), by an electrospinning technique. The morphology and average diameter of the nanofibers were investigated by scanning electron microscopy (SEM). The optimum ratio (3/7) was used to load gatifloxacin hydrochloride (GH) (1wt %), found to form smooth fibers with uniform structures. The drug entrapment in the composite nanofibers was confirmed by SEM, X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermo gravimetric analysis (TGA), differential scanning calorimetry (DSC), and swelling behavior. The drug release behavior was investigated using phosphate-buffered saline (PBS) (pH 7.4) at 37°C for 24 h. The XRD and FTIR data demonstrate that there are good interactions between PVA and SA, possibly caused by hydrogen bonds. As much as 90% of the GH was released from the electrospun fibers within 6 h of incubation. Beyond this, the release was sustained for 24 h. The thickness of nanofibers greatly influenced the initial release and rate of drug release. Moreover, GH-loaded sodium alginate/PVA composite nanofibers exhibited a useful and convenient method for electrospinning in order to control the rate and period of drug release in wound-healing applications.

Folic acid-containing nanofibers by simultaneous process for transdermal drug delivery: preparation, characterization, and in vitro biocompatibility

“…7 showed diffusion based drug release occured for 30 min, then followed by a constant drug release till 8 h due to erosion of polymer matrix. Similar UV-Vis results were reported by Arthani et al [53]. However, the release rate in PVA-Gel/FA ber is partially slower than others for the rst 30 min.…”

“…The electrospun PVA-Alg and PVA bers were same absorption peaks approximately. However, the absorption peaks at 3284 cm -1 (-OH stretching) belongs to PVA that shifted to the 3297 cm -1 [53,54].…”

Recent advances on biomedical applications of scaffolds in wound healing and dermal tissue engineering

“…Also, alginates were extensively used for the tissue engineering scaffold fabrication [72][73][74]. For example, the alginate microspheres [75] or combination of the alginate, chitosan and chit oligosaccharides (alginate-chitosan-cos) and alginate chitosan, chit oligosaccharides with collagen (alginate-chitosan-cos-collagen) scaffold was used for the skin substitute and was illustrated that these scaffolds were improved the biocompatible nature that mimicked the functional environment of skin [76][77][78].…”

Fabrication of mucoadhesive chitosan coated polyvinylpyrrolidone/cyclodextrin/clotrimazole sandwich patches for oral candidiasis

“…Electrospun nanofibers offer great flexibility in the selection of materials or drugs for drug delivery applications. Moreover, electrospun nanofibers exhibit marvelous characteristics such as high loading capacity, high encapsulation efficiency, they provide coincident delivery of various compounds, and are cost effective (Arthanari et al, 2014;Hu et al, 2014;Van Roey, Haxaire, Kamya, Lwanga, & Katabira, 2004). In our previous study, the fast dissolving CZ-loaded nanofiber mats were fabricated using PVP/HP␤CD as the fiber forming polymer.…”