Clinical Applications of Pediatric Positron Emission Tomography-Magnetic Resonance Imaging

Teixeira, Sara Reis; Martínez-Ríos, Claudia; Hu, Lianghai; Bangert, Barbara

doi:10.1053/j.ro.2014.10.002

Cited by 9 publications

(7 citation statements)

References 102 publications

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“…Paediatric and pregnant patients may benefit from MRI PET because of reduced radiation burden as compared to PET CT. MRI PET may play a valuable role in the evaluation of paediatric lymphomas, neuroblastomas. and soft tissue sarcomas [ 22 , 23 ].…”

Section: Imaging Techniquesmentioning

confidence: 99%

“…Whole-body MRI has shown comparable results as PET CT, and more accuracy as compared to skeletal scintigraphy in the detection of osseous metastases of RMS [ 65 ]. MRI PET may potentially improve the staging, follow-up and post-treatment assessment of RMS [ 22 ].…”

Section: Compartment-based Approach To Orbital Massesmentioning

confidence: 99%

“…Whole body PET CT has become part of standard staging of orbital lymphomas and is probably used more widely for this disease than any other orbital tumour Although, low-grade MALT lymphomas may show relatively low FDG uptake, PET CT has shown very good results in the detection of systemic metastases of even low-grade orbital lymphomas, which were not detected by conventional imaging [ 18 , 20 , 71 , 72 ]. MRI PET holds promise in evaluating post-treatment response of lymphomas, especially in children [ 22 , 73 ].…”

Section: Compartment-based Approach To Orbital Massesmentioning

confidence: 99%

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Orbital tumours and tumour-like lesions: exploring the armamentarium of multiparametric imaging

et al. 2015

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Although the orbit is a small anatomical space, the wide range of structures present within it are often the site of origin of various tumours and tumour-like conditions, both in adults and children. Cross-sectional imaging is mandatory for the detection, characterization, and mapping of these lesions. This review focuses on multiparametric imaging of orbital tumours. Each tumour is reviewed in relation to its clinical presentation, compartmental location, imaging characteristics, and its histological features. We herein describe orbital tumours as lesions of the globe (retinoblastoma, uveal melanoma), optic nerve sheath complex (meningioma, optic nerve glioma), conal-intraconal compartment (hemangioma), extraconal compartment (dermoid/epidermoid, lacrimal gland tumours, lymphoma, rhabdomysarcoma), and bone and sinus compartment (fibrous dysplasia). Lesions without any typical compartmental localization and those with multi-compartment involvement (veno-lymphatic malformation, plexiform neurofibroma, idiopathic orbital pseudotumour, IgG4 related disease, metastases) are also reviewed. We discuss the role of advanced imaging techniques, such as MR diffusion-weighted imaging (DWI), diffusion tensor imaging, fluoro-2-deoxy-D-glucose positron emission tomography CT (FDG-PET CT), and positron emission tomography MRI (MRI PET) as problem-solving tools in the evaluation of those orbital masses that present with non-specific morphologic imaging findings.Main messages/Teaching points• A compartment-based approach is essential for the diagnosis of orbital tumours.• CT and MRI play a key role in the work-up of orbital tumours.• DWI, PET CT, and MRI PET are complementary tools to solve diagnostic dilemmas.• Awareness of salient imaging pearls and diagnostic pitfalls avoids interpretation errors.

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Section: Imaging Techniquesmentioning

confidence: 99%

Section: Compartment-based Approach To Orbital Massesmentioning

confidence: 99%

Section: Compartment-based Approach To Orbital Massesmentioning

confidence: 99%

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Orbital tumours and tumour-like lesions: exploring the armamentarium of multiparametric imaging

et al. 2015

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“…The main advantage of MRI is a lack of ionizing radiation especially for a patient with a non-oncological disease or a potentially curable oncological disease. But it is not important for oncological patients (17,25,26). 6.…”

Section: A Great Number Of Papers About Evaluating and Determiningmentioning

confidence: 99%

“…However this is only advantageous when MR data acquisition, MR gating data, and PET data are acquired simultaneously and for similar amounts of time, as otherwise MR is just an expensive device to provide gating information for PET. 5The main advantage of MRI is a lack of ionizing radiation especially for a patient with a non‐oncological disease or a potentially curable oncological disease. But it is not important for oncological patients . 6Combined PET/MRI may decrease the imaging time; thus, by reducing appointment periods, department logistics have to be improved .…”

Section: Introductionmentioning

confidence: 99%

Dual nano‐sized contrast agents in PET/MRI: a systematic review

Lahooti

Sarkar

Laurent

et al. 2016

Contrast Media & Molecular

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Nowadays molecular imaging plays a vital role in achieving a successful targeted and personalized treatment. Hence, the approach of combining two or more medical imaging modalities was developed. The objective of this review is to systematically compare recent dual contrast agents in Positron Emission Tomography (PET)/Magnetic Resonance Imaging (MRI) and in some cases Single photon emission computed tomography (SPECT)/MRI in terms of some their characteristics, such as tumor uptake, and reticuloendothelial system uptake (especially liver) and their relaxivity rates for early detection of primary cancer tumor. To the best of our knowledge, this is the first systematic and integrated overview of this field. Two reviewers individually directed the systematic review search using PubMed, MEDLINE and Google Scholar. Two other reviewers directed quality assessment, using the criteria checklist from the CAMARADES (Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies) tool, and differences were resolved by consensus. After reviewing all 49 studies, we concluded that a size range of 20-200 nm can be used for molecular imaging, although it is better to try to achieve as small a size as it is possible. Also, small nanoparticles with a hydrophilic coating and positive charge are suitable as a T contrast agent. According to our selected data, the most successful dual probes in terms of high targeting were with an average size of 40 nm, PEGylated using peptides as a biomarker and radiolabeled with copper 64 and gallium 68. Copyright © 2017 John Wiley & Sons, Ltd.

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