Utilization of star-shaped polymer architecture in the creation of high-density polymer brush coatings for the prevention of platelet and bacteria adhesion

Totani, Masayasu; Ando, Tetsu; Terada, Kazumasa; Terashima, Takaya; Kim, Ill Yong; Ohtsuki, Chikara; Xi, Chuanwu; Kuroda, Kenichi; Tanihara, Masao

doi:10.1039/c4bm00034j

Cited by 21 publications

(13 citation statements)

References 54 publications

(75 reference statements)

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“…Many polymer platforms have been studied, including random and block copolymers, star-shaped polymers, and graft copolymers [15,31,32]. However, the role of aggregates in their antimicrobial mechanisms is not clear yet.…”

Section: Discussionmentioning

confidence: 99%

Aggregation of Cationic Amphiphilic Block and Random Copoly(vinyl ether)s with Antimicrobial Activity

et al. 2018

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Abstract:In this study, we investigated the aggregation behaviors of amphiphilic poly(vinyl ether)s with antimicrobial activity. We synthesized a di-block poly(vinyl ether), B38 26 , composed of cationic primary amine and hydrophobic isobutyl (iBu) side chains, which previously showed antimicrobial activity against Escherichia coli. B38 26 showed similar uptake behaviors as those for a hydrophobic fluorescent dye, 1,6-diphenyl-1,3,5-hexatriene, to counterpart polymers including homopolymer H44 and random copolymer R40 25 , indicating that the iBu block does not form strong hydrophobic domains. The cryo-TEM observations also indicated that the polymer aggregate of B38 26 appears to have low-density polymer chains without any defined microscopic structures. We speculate that B38 26 formed large aggregates by liquid-liquid separation due to the weak association of polymer chains. The fluorescence microscopy images showed that B38 26 bonds to E. coli cell surfaces, and these bacterial cells were stained by propidium iodide, indicating that the cell membranes were significantly damaged. The results suggest that block copolymers may provide a new platform to design and develop antimicrobial materials that can utilize assembled structures and properties.

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Section: Discussionmentioning

confidence: 99%

Aggregation of Cationic Amphiphilic Block and Random Copoly(vinyl ether)s with Antimicrobial Activity

et al. 2018

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“…Analysis of Polymerization Process in Materials and Methods for Equation (2)) and the molar ratio of CTA to monomers ([SH]/[monomer]). We have previously prepared star-shape polymers with 10-12 polymer chain arms by crosslinking the end groups of pre-existing polyHEMA polymer chains [17]. However, this preparation method required multiple synthesis and purification steps.…”

Section: Synthesis Of 4-and 6-arm Star-shaped Polymers and Characterimentioning

confidence: 99%

Understanding the Role of Shape and Composition of Star-Shaped Polymers and their Ability to Both Bind and Prevent Bacteria Attachment on Oral Relevant Surfaces

Mortazavian

Picquet

Lejnieks

et al. 2019

JFB

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In this study, we have prepared a series of 4- and 6-arm star-shaped polymers with varying molecular weight and hydrophobicity in order to provide insight into the role and relationship that shape and composition have on the binding and protecting of oral relevant surfaces (hydroxyapatite, HAP) from bacteria colonization. Star-shaped acrylic acid polymers were prepared by free-radical polymerization in the presence of chain transfer agents with thiol groups, and their binding to the HAP surfaces and subsequent bacteria repulsion was measured. We observed that binding was dependent on both polymer shape and hydrophobicity (star vs. linear), but their relative efficacy to reduce oral bacteria attachment from surfaces was dependent on their hydrophobicity only. We further measured the macroscopic effects of these materials to modify the mucin-coated HAP surfaces through contact angle experiments; the degree of angle change was dependent on the relative hydrophobicity of the materials suggesting future in vivo efficacy. The results from this study highlight that star-shaped polymers represent a new material platform for the development of dental applications to control bacterial adhesion which can lead to tooth decay, with various compositional and structural aspects of materials being vital to effectively design oral care products.

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“…Branched copolymers, such as star-shaped copolymers, hyper-branched copolymers, and dendrimers, have been highlighted owing to excellent mechanical and rheological properties 16,17. Star-shaped block copolymer is a branched polymer, the branches of which all extend to form a core 18.…”

Section: Introductionmentioning

confidence: 99%

“… 14 , 15 Branched copolymers, such as star-shaped copolymers, hyper-branched copolymers, and dendrimers, have been highlighted owing to excellent mechanical and rheological properties. 16 , 17 Star-shaped block copolymer is a branched polymer, the branches of which all extend to form a core. 18 The drug carriers based on star-shaped polymers have smaller hydrodynamic radii as well as high EEs and loading contents (LCs) than those of the linear polymers with similar molecular weights.…”

Section: Introductionmentioning

confidence: 99%

Paclitaxel-loaded star-shaped copolymer nanoparticles for enhanced malignant melanoma chemotherapy against multidrug resistance

Su¹,

Hu²,

Huang³

et al. 2017

DDDT

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Malignant melanoma (MM) is the most dangerous type of skin cancer with annually increasing incidence and death rates. However, chemotherapy for MM is restricted by low topical drug concentration and multidrug resistance. In order to surmount the limitation and to enhance the therapeutic effect on MM, a new nanoformulation of paclitaxel (PTX)-loaded cholic acid (CA)-functionalized star-shaped poly(lactide-co-glycolide) (PLGA)-D-α-tocopheryl polyethylene glycol 1000 succinate (TPGS) nanoparticles (NPs) (shortly PTX-loaded CA-PLGA-TPGS NPs) was fabricated by a modified method of nanoprecipitation. The particle size, zeta potential, morphology, drug release profile, drug encapsulation efficiency, and loading content of PTX-loaded NPs were detected. As shown by confocal laser scanning, NPs loaded with coumarin-6 were internalized by human melanoma cell line A875. The cellular uptake efficiency of CA-PLGA-TPGS NPs was higher than those of PLGA NPs and PLGA-TPGS NPs. The antitumor effects of PTX-loaded NPs were evaluated by the MTT assay in vitro and by a xenograft tumor model in vivo, demonstrating that star-shaped PTX-loaded CA-PLGA-TPGS NPs were significantly superior to commercial PTX formulation Taxol®. Such drug delivery nanocarriers are potentially applicable to the improvement of clinical MM therapy.

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Utilization of star-shaped polymer architecture in the creation of high-density polymer brush coatings for the prevention of platelet and bacteria adhesion

Cited by 21 publications

References 54 publications

Aggregation of Cationic Amphiphilic Block and Random Copoly(vinyl ether)s with Antimicrobial Activity

Aggregation of Cationic Amphiphilic Block and Random Copoly(vinyl ether)s with Antimicrobial Activity

Understanding the Role of Shape and Composition of Star-Shaped Polymers and their Ability to Both Bind and Prevent Bacteria Attachment on Oral Relevant Surfaces

Paclitaxel-loaded star-shaped copolymer nanoparticles for enhanced malignant melanoma chemotherapy against multidrug resistance

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