Toxicity of the veterinary sulfonamide antibiotic sulfamonomethoxine to five aquatic organisms

Huang, Daji; Hou, Jung-Hsin; Kuo, Ting‐Shen; Lai, Hong‐Thih

doi:10.1016/j.etap.2014.09.006

Cited by 62 publications

(16 citation statements)

References 28 publications

(37 reference statements)

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“…At the genus level, Limnohabitans has been reported as one of the most stable and dominant gut microbiota members in Daphnia; moreover, variation in its abundance has been positively related to the animal fecundity [22]. Although some studies have addressed the dependence of Daphnia on its microbiota [9], including short-term effects on fitness following exposure to antibiotics in Daphnia magna [23,24], the relationships between microflora perturbation and host fitness are still unclear, as is the involvement and modulating role of antioxidants in the host responses.…”

Section: Introductionmentioning

confidence: 99%

Disparate effects of antibiotic-induced microbiome change and enhanced fitness in Daphnia magna

et al. 2020

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It is a common view that an organism's microbiota has a profound influence on host fitness; however, supporting evidence is lacking in many organisms. We manipulated the gut microbiome of Daphnia magna by chronic exposure to different concentrations of the antibiotic Ciprofloxacin (0.01-1 mg L-1), and evaluated whether this affected the animals fitness and antioxidant capacity. In line with our expectations, antibiotic exposure altered the microbiome in a concentration-dependent manner. However, contrary to these expectations, the reduced diversity of gut bacteria was not associated with any fitness detriment. Moreover, the growth-related parameters correlated negatively with microbial diversity; and, in the daphnids exposed to the lowest Ciprofloxacin concentrations, the antioxidant capacity, growth, and fecundity were even higher than in control animals. These findings suggest that Ciprofloxacin exerts direct stimulatory effects on growth and reproduction in the host, while microbiome-mediated effects are of lesser importance. Thus, although microbiome profiling of Daphnia may be a sensitive tool to identify early effects of antibiotic exposure, disentangling direct and microbiome-mediated effects on the host fitness is not straightforward.

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Section: Introductionmentioning

confidence: 99%

Disparate effects of antibiotic-induced microbiome change and enhanced fitness in Daphnia magna

et al. 2020

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“…In another study, florfenicol, one of the most commonly used antibiotic in aquaculture, was noted to cause a significant inhibition of cholinesterase activity in a bivalve Corbicula fluminea (Guilhermino et al 2018 ) and suppression of hepatopancreatic antioxidant system in the gazami crab Portunus trituberculatus (Ren et al 2017 ). Some antibiotics were also reported to induce toxic effects in a freshwater crustacean Daphnia magna such as lethality, inhibition of growth and reproduction in addition to bioaccumulation (Wollenberger et al 2000 ; Martins et al 2013 ; Kim et al 2014 ; Kim et al 2017 ; Huang et al 2014 ; Dalla Bona et al 2016 ; Ribeiro et al 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Procaine penicillin alters swimming behaviour and physiological parameters of Daphnia magna

Bownik

Ślaska

Bochra

et al. 2019

Environ Sci Pollut Res

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Procaine penicillin (PP) is a β-lactam antibiotic widely used in human and veterinary medicine. Although PP is detected in surface water, little is known on its effects on aquatic invertebrates. Our aim was to determine the influence of PP on swimming behaviour (track density, swimming speed, turning angle, hopping frequency) and physiological activity (oxygen consumption, heart rate, thoracic limb movement) of a freshwater invertebrate Daphnia magna exposed to PP at concentrations of 11.79 mg/L, 117.9 mg/L and 1179 mg/L for 2 h and 24 h. The results showed no mortality; however, reduction of swimming activity manifested by the decreased track density, swimming speed and turning angle noted in Daphnia exposed to all the concentrations of PP. Increase of oxygen consumption was observed after 2-h exposure; however, decrease of this parameter was found after 24 h. PP also reduced heart rate and thoracic limb movement in a concentration-dependent manner. The results suggest that the antibiotic should not induce mortality; however, it may affect swimming behaviour and physiological parameters of Daphnia magna particularly inhabiting aquaculture facilities with intensive antibiotic treatment. On the basis of the present results, we also suggest higher sensitivity of behavioural and physiological parameters of cladocerans than the commonly used endpoints: mortality or immobilisation and their possible application as a part of early warning systems in monitoring of surface water toxicity.

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“…Tetracyclines were present in high levels in the Wangyang river [19]. Longterm exposure to antimicrobial agents in aquatic environments imposes a threat on aquatic organisms [20,21] and accelerates the development of antibiotic-resistant microorganisms. Once antibiotic-resistant microorganisms appear in the environment, they may enlarge the resistance community through the transfer of corresponding antibiotic resistance genes among microbial populations in different environmental systems [6,22].…”

Section: Occurrence and Distribution Of Veterinary Residues In Aquatimentioning

confidence: 99%

Occurrence and Distribution of Veterinary Residues in Aquatic Environments near Livestock and Poultry Farms in Zhejiang Province, China

Wang¹,

Wu²,

Qian³

et al. 2018

Asian J. Chem.

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Five categories of antibiotics viz., nineteen fluoroquinolones, sixteen sulfonamides, four tetracyclines, three chloramphenicols, four nitroimidazoles and three of their metabolites were measured in 72 water samples from the river near the livestock and poultry farms in Zhejiang province of China. 48.6 % water sample was positive with at least one drug residue. The detection frequency ranged from 8.3 % for fluoroquinolones to 37.5 % for chloramphenicols. For all the target veterinary drugs, florfenicol had the highest occurrence of 31.9 % with the mean concentration of 484.3 ng L-1. Based on the calculation of hazard quotients, the risk to the aquatic organisms was evaluated and it was demonstrated that the occurrence of sulfamethoxazole, sulfamonomethoxine and florfenicol might pose a risk to aquatic organisms in some study areas.

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Toxicity of the veterinary sulfonamide antibiotic sulfamonomethoxine to five aquatic organisms

Cited by 62 publications

References 28 publications

Disparate effects of antibiotic-induced microbiome change and enhanced fitness in Daphnia magna

Disparate effects of antibiotic-induced microbiome change and enhanced fitness in Daphnia magna

Procaine penicillin alters swimming behaviour and physiological parameters of Daphnia magna

Occurrence and Distribution of Veterinary Residues in Aquatic Environments near Livestock and Poultry Farms in Zhejiang Province, China

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