Vitamin D Deficiency in Mycosis Fungoides and Sézary Syndrome Patients Is Similar to Other Cancer Patients

Talpur, Rakhshandra; Cox, Katherine M.; Hu, Mimi I.; Geddes, Elizabeth R.; Parker, Mary K.; Yang, Bishan; Armstrong, P.; Liu, Ping; Duvic, Madeleine

doi:10.1016/j.clml.2014.06.023

Cited by 24 publications

(28 citation statements)

References 38 publications

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“…In a recent study, Duvic et al investigated an association between vitamin D deficiency and MF/SS. 36 This study documented that vitamin D deficiency was observed in~77% of CTCL patients, and is comparable to vitamin D deficiency in other cancer patients (~75% of patients). 36 In contrast, extensive literature in the field documents that vitamin D deficiency is usually present in only~30-40% of individuals in the general United States population.…”

supporting

confidence: 67%

“…36 This study documented that vitamin D deficiency was observed in~77% of CTCL patients, and is comparable to vitamin D deficiency in other cancer patients (~75% of patients). 36 In contrast, extensive literature in the field documents that vitamin D deficiency is usually present in only~30-40% of individuals in the general United States population. 37 In recent years, vitamin D has been recognized as an emerging anticancer and immunomodulatory agent.…”

supporting

confidence: 67%

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Investigating potential exogenous tumor initiating and promoting factors for Cutaneous T-Cell Lymphomas (CTCL), a rare skin malignancy

et al. 2016

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Most skin malignancies are caused by external and often preventable environmental agents. Multiple reports demonstrated that cutaneous T-cell lymphomas (CTCL) can occur in married couples and cluster in families. Furthermore, recent studies document geographic clustering of this malignancy in Texas as well as in other areas of the United States. Multiple infectious, occupational, and medication causes have been proposed as triggers or promoters of this malignancy including hydrochlorothiazide diuretics, Staphylococcus aureus, dermatophytes, Mycobacterium leprae, Chlamydia pneumoniae, human T-Cell lymphotropic virus type 1 (HTLV1), Epstein-Barr virus (EBV), and herpes simplex virus (HSV). In this report, we review recent evidence evaluating the involvement of these agents in cancer initiation/progression. Most importantly, recent molecular experimental evidence documented for the first time that S. aureus can activate oncogenic STAT3 signaling in malignant T cells. Specifically, S. aureus Enterotoxin type A (SEA) was recently shown to trigger non-malignant infiltrating T cells to release IL-2 and other cytokines. These signals upon binging to their cognate receptors on malignant T cells are then able to activate STAT3 and STAT5 oncogenic signaling and promote cancer progression and IL-17 secretion. In light of these findings, it might be important for patients with exacerbation of their CTCL symptoms to maintain high index of suspicion and treat these individuals for S. aureus colonization and/or sepsis with topical and systemic antibiotics.

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supporting

confidence: 67%

supporting

confidence: 67%

Investigating potential exogenous tumor initiating and promoting factors for Cutaneous T-Cell Lymphomas (CTCL), a rare skin malignancy

et al. 2016

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“…Our African American cohort was also significantly less likely to have vitamin D deficiency when compared with the general population (Table A2). These observations diverge from that of Talpur et al who found about 77% of their CTCL patients to be deficient in vitamin D deficiency [31]. One rationale could be the use of phototherapy which may have led to improved vitamin D levels in our cohort, however, further longitudinal studies may be required for confirmation.…”

Section: Discussioncontrasting

confidence: 97%

Comorbidities in Mycosis Fungoides and Racial Differences in Co-Existent Lymphomatoid Papulosis: A Cross-Sectional Study of 580 Patients in an Urban Tertiary Care Center

et al. 2019

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Background: Mycosis fungoides (MF) is a cutaneous T-cell lymphoma. Previous reports have suggested MF is associated with inflammatory conditions such as psoriasis, increased cardiovascular risk factors as well as secondary neoplasms. Methods: A cross-sectional study of MF patients seen from 2013 to 2019 was performed. Comorbidities were selected based on the 2015 Medicare report highlighting the most common chronic medical illnesses in the United States. Lifetime comorbidity occurrence in patients with MF were compared with that in patients with atopic dermatitis, psoriasis and patients without MF. Additional analyses were performed with patients sub-stratified by race. Results: Compared to control groups, MF was strongly associated with lymphomatoid papulosis and Hodgkin’s disease, but not significantly associated with lung, breast or colon cancer. Interestingly, the association with lymphomatoid papulosis was observed in Caucasians (CI 1062-4338; p < 0.001) and not African Americans (p = 0.9). Patients with MF had a greater association with congestive heart failure, hypertension (HT) and hyperlipidemia (HLD) compared with the general population. However, they were significantly less likely to have HT and HLD when compared with psoriasis patients (HT CI: 0.6–0.9; p < 0.001, and HLD CI: 0.05–0.07; p < 0.001). MF patients were also significantly less likely to have concomitant vitamin D deficiency compared with atopic dermatitis (AD) and psoriasis (p < 0.001). Conclusions: Our results suggest that the association of MF with lymphomatoid papulosis varies by race. Compared to the general population, hypertension and hyperlipidemia were positively associated with MF, however, these were significantly less likely on comparison to psoriasis. Unlike previously described, vitamin D deficiency was found to be significantly less in patients with MF.

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“…Regional variations in incidence of disease, geographic or familial (e.g. married couples) clustering, drug triggers (antihistamines, antiepileptics, anti hypertensives, SSRIs)[9] and occupational/nutritional associations including exposure to aromatic hydrocarbons or vitamin D deficiency support an environmental role in the evolution of CTCL [10–16]. In some patients a shift of TH1 to Th2 cytokines may drive progression of CTCL in a positive feedback loop, e.g.…”

Section: Etiology/pathogenesismentioning

confidence: 99%

Cutaneous T-cell Lymphoma

Pulitzer

2017

Clinics in Laboratory Medicine

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Synopsis Cutaneous T-cell lymphomas comprise a heterogeneous group of diseases characterized by monoclonal proliferations of T-lymphocytes primarily involving skin, modified skin appendages and some mucosal sites. This review addresses the basic clinical, histologic and immunohistochemical characteristics of this group of diseases, with additional attention to evolving literature on dermoscopy, reflectance confocal microscopy, flow cytometry and molecular data that may increasingly be applied to diagnostic and therapeutic algorithms in these diseases. Select unusual phenotypes, or diagnostic examples of classic phenotypes are demonstrated, and flags for consideration while making a pathologic diagnosis of CTCL are suggested.

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Vitamin D Deficiency in Mycosis Fungoides and Sézary Syndrome Patients Is Similar to Other Cancer Patients

Cited by 24 publications

References 38 publications

Investigating potential exogenous tumor initiating and promoting factors for Cutaneous T-Cell Lymphomas (CTCL), a rare skin malignancy

Investigating potential exogenous tumor initiating and promoting factors for Cutaneous T-Cell Lymphomas (CTCL), a rare skin malignancy

Comorbidities in Mycosis Fungoides and Racial Differences in Co-Existent Lymphomatoid Papulosis: A Cross-Sectional Study of 580 Patients in an Urban Tertiary Care Center

Cutaneous T-cell Lymphoma

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