Mortality in women with pregnancy-associated malignant melanoma

Johansson, Anna L.V.; Andersson, Therése; Plym, Anna; Ullenhag, Gustav; Møller, Henrik; Lambe, Mats

doi:10.1016/j.jaad.2014.09.018

Cited by 51 publications

(55 citation statements)

References 24 publications

(52 reference statements)

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“…The definition of PAMM varies across studies, with the window of diagnosis varying from diagnosis during pregnancy to diagnosis as far out as 5 years postpartum. 16 Fortunately, some of these studies perform additional analyses in which the group diagnosed during pregnancy was separated from those diagnosed in the postpartum period. While the population-based cohort studies offer the advantage of large numbers of patients, data are often incomplete concerning Breslow depth of the primary tumor and stage of disease.…”

Section: Introductionmentioning

confidence: 99%

“…Nonetheless, we have based our conclusions on the best data available. Overall, most small, controlled studies 17-23 and large, population-based cohort studies 16,[24][25][26][27] have reported no significant influence of pregnancy on survival in women diagnosed with MM compared with women not pregnant at the time of diagnosis (Table I). Two studies 17,18 from 1 institutional database showed a shorter disease-free interval (DFI) in the pregnant group compared to controls, but 3 other trials 19,21,22 that calculated DFI did not find any effect (Table I).…”

Section: Introductionmentioning

confidence: 99%

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Pregnancy and melanoma

Driscoll

Martires

Bieber

et al. 2016

Journal of the American Academy of Dermatology

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pregnancy and melanoma

Driscoll

Martires

Bieber

et al. 2016

Journal of the American Academy of Dermatology

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“…Estrogen inhibits the growth of human melanoma cell lines by reducing the expression of IL8 [19]. Previous assumptions suggested that PAM had worse prognosis, however several publications have refuted this [20][21][22]. Nonetheless, a newly published meta-analysis reported increased mortality in PAM [23].…”

Section: Discussionmentioning

confidence: 99%

“…The mean age of women at melanoma diagnosis was 32.5 ± 5.6 years (min.-max. [22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40]. Most PAMs (23/34, 67.6 %) were diagnosed at very early stages (2/34 (5.9 %) in situ melanoma, 21/34 (61.7 %) stage I melanoma).…”

Section: Temporal Relation and Clinical Staging Of Melanoma To Pregnancymentioning

confidence: 99%

Retrospective Analysis of Clinicopathological Characteristics of Pregnancy Associated Melanoma

Fábián

Tóth

Somlai

et al. 2015

Pathol. Oncol. Res.

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Pregnancy associated melanoma (PAM) by definition appears during pregnancy or within 1 year after delivery. In this retrospective study we analysed the pathological characteristics and survival rate of PAM and matched the data with non-pregnant age- and stage-matched control patients. Between 2003 and 2014, 34 pregnant women (aged 32.5 ± 5.6 years) were diagnosed with melanoma at the Department of Dermatology, Venereology and Dermatooncology of the Semmelweis University. During the pathological process histologic subtype, Breslow thickness and Clark level, tumor cell type, mitotic rate, peritumoral inflammation, as well as ulceration, regression, necrosis, vascular invasion and presence of satellite were analyzed and related to clinical data. Primary tumor location and clinical staging, disease course, local recurrence and metastases, 5-year survival rate, other tumor development before or after the diagnosis of melanoma have also been documented. We found no difference in all parameters between pregnant and non-pregnant melanoma cases except peritumoral inflammation which was higher in PAM group, moreover the presence of mild inflammation was significantly higher in PAM group compared to non-pregnancy associated melanoma (NPAM) women group.

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“…Breslow's depth is also never specifically mentioned. To test our conclusions regarding Byrom et al's meta-analysis, 1 we re-calculated a summary effect for a meta-analysis using HRs reported by Johanssen et al 7 (in place of Lens et al 3 ), MacKie et al 2 and the adjusted Steinsheim et al 4 We excluded the study by Moller et al 5 due to inconsistency of their definition of PAM. Our summary effect shows a HR = 1.19 (0.96, 1.48) (Fig.…”

mentioning

confidence: 99%