Dim light at night increases body mass of female mice

Aubrecht, Taryn G.; Jenkins, Richelle; Nelson, Randy J.

doi:10.3109/07420528.2014.986682

Cited by 38 publications

(30 citation statements)

References 19 publications

(27 reference statements)

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“…Studies have shown that dim light at night can increase body weight in mice (Aubrecht et al 2014; Fonken et al 2013a; Kott et al 2012). In this study, rats that underwent TBI and received constant light exposure had a lower body weight than rats that underwent TBI with a normal LD cycle, suggesting that circadian disruption, which is associated with temporal alterations in feeding behavior, might inhibit post-TBI functional recovery.…”

Section: Discussionmentioning

confidence: 99%

Environmental Circadian Disruption Worsens Neurologic Impairment and Inhibits Hippocampal Neurogenesis in Adult Rats After Traumatic Brain Injury

Guo

et al. 2016

Cell Mol Neurobiol

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Circadian rhythms modulate many physiologic processes and behaviors. Therefore, their disruption causes a variety of potential adverse effects in humans and animals. Circadian disruption induced by constant light exposure has been discovered to produce pathophysiologic consequences after brain injury. However, the underlying mechanisms that lead to more severe impairment and disruption of neurophysiologic processes are not well understood. Here, we evaluated the effect of constant light exposure on the neurobehavioral impairment and survival of neurons in rats after traumatic brain injury (TBI). Sixty adult male Sprague–Dawley rats were subjected to a weight-drop model of TBI and then exposed to either a standard 12-/12-h light/dark cycle or a constant 24-h light/light cycle for 14 days. Our results showed that 14 days of constant light exposure after TBI significantly worsened the sensorimotor and cognitive deficits, which were associated with decreased body weight, impaired water and food intake, increased cortical lesion volume, and decreased neuronal survival. Furthermore, environmental circadian disruption inhibited cell proliferation and newborn cell survival and decreased immature cell production in rats subjected to the TBI model. We conclude that circadian disruption induced by constant light exposure worsens histologic and neurobehavioral impairment and inhibits neurogenesis in adult TBI rats. Our novel findings suggest that light exposure should be decreased and circadian rhythm reestablished in hospitalized TBI patients and that drugs and strategies that maintain circadian rhythm would offer a novel therapeutic option.

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Section: Discussionmentioning

confidence: 99%

Environmental Circadian Disruption Worsens Neurologic Impairment and Inhibits Hippocampal Neurogenesis in Adult Rats After Traumatic Brain Injury

Guo

et al. 2016

Cell Mol Neurobiol

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“…Shift workers who work from 10 pm to 6 am make up about 20% of working force in modern society (Antunes et al, 2010) and have a higher prevalence of obesity and heart disease (Karlsson et al, 2001; Kubo et al, 2011; Suwazono et al, 2008). Dim light at night or prolonged daily light exposure promotes obesity and metabolic disorders in animal models (Aubrecht et al, 2015; Kooijman et al, 2015; Opperhuizen et al, 2015). Housing mice under constant light caused arrhythmicity in locomotor activity, increased food intake, reduced energy expenditure, increased body fat mass, and impaired insulin sensitivity (Coomans et al, 2013a; Shi et al, 2013).…”

Section: Evidence Supporting a Role Of Central Clock In Energy Metabomentioning

confidence: 99%

Central Circadian Clock Regulates Energy Metabolism

Ding¹,

Gong²,

Eckel‐Mahan³

et al. 2018

Advances in Experimental Medicine and Biology

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Our body not only responds to environmental changes but also anticipates them. The light and dark cycle with the period of about 24 hours is a recurring environmental change that determines the diurnal variation in food availability and safety from predators in nature. As a result, the circadian clock is evolved in most animals to align locomotor behaviors and energy metabolism with the light cue. The central circadian clock in mammals is located at the suprachiasmatic nucleus (SCN) of the hypothalamus in the brain. We here review the molecular and anatomic architecture of the central circadian clock in mammals; describe the experimental and observational evidence that suggests a critical role of the central circadian clock in shaping systemic energy metabolism; and discuss the involvement of endocrine factors, neuropeptides, and the autonomic nervous system in the metabolic functions of the central circadian clock.

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“…(56-58) One important point to keep in mind, however, is that the spectral and absolute sensitivities to light are species-specific. Animal work, therefore, can be only be translated to human models once these spectral and absolute sensitivities to light are taken into account.…”

Section: Introductionmentioning

confidence: 99%

Disruption of Circadian Rhythms by Light During Day and Night

Figueiro

2017

Curr Sleep Medicine Rep

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Purpose of review This study aims to discuss possible reasons why research to date has not forged direct links between light at night, acute melatonin suppression or circadian disruption, and risks for disease. Recent Findings Data suggest that irregular light–dark patterns or light exposures at the wrong circadian time can lead to circadian disruption and disease risks. However, there remains an urgent need to: (1) specify light stimulus in terms of circadian rather than visual response; (2) when translating research from animals to humans, consider species-specific spectral and absolute sensitivities to light; (3) relate the characteristics of photometric measurement of light at night to the operational characteristics of the circadian system; and (4) examine how humans may be experiencing too little daytime light, not just too much light at night. Summary To understand the health effects of light-induced circadian disruption, we need to measure and control light stimulus during the day and at night.

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Dim light at night increases body mass of female mice

Cited by 38 publications

References 19 publications

Environmental Circadian Disruption Worsens Neurologic Impairment and Inhibits Hippocampal Neurogenesis in Adult Rats After Traumatic Brain Injury

Environmental Circadian Disruption Worsens Neurologic Impairment and Inhibits Hippocampal Neurogenesis in Adult Rats After Traumatic Brain Injury

Central Circadian Clock Regulates Energy Metabolism

Disruption of Circadian Rhythms by Light During Day and Night

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