Combined use of Chinese medicine with allogeneic hematopoietic stem cell transplantation for severe aplastic anemia patients

Ye, Baodong; Zhang, Xiang; Shao, Keding; Chen, Dan; Wu, Denghao; Q, Yu; Shen, Jianping; Shen, Yueqian; Zhou, Yuhong

doi:10.1007/s11655-014-2026-9

Cited by 8 publications

(9 citation statements)

References 18 publications

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“…A study on autologous and allogenic HSC transplanted in patients with chronic granulocytic leukaemia, acute non-lymphocytic leukaemia and lymphoma were treated with CHM concluded that treating with CHM reduces complications of transplantations and promotes recovery of haematopoietic functions [36]. More research on various other HSC transplantations against haematological malignancies such as severe aplastic anaemia patients [37], patients with myelodysplastic syndrome [38] and acute paediatric leukaemia [39] were cited herein [35], which had given positive results on patient survival rates, reduction of complications and increasing functional properties of haematopoietic cells. However, most of these studies were based on a low number of samples; hence, the need to perform such studies in large populations arises in order to validate and standardize the CHM procedures.…”

Section: Effects Of Herbal Extracts On Human Stem Cells 21 Stimulatmentioning

confidence: 99%

Application of Herbal Medicine as Proliferation and Differentiation Effectors of Human Stem Cells

Udagama¹,

Udalamaththa²

2019

Herbal Medicine

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One of the main streams of traditional medicine is herbal medicine; a wide range of medicinal plants and their individual parts are used for therapy. Though not scientifically validated, this traditional medicine practice is much popular in countries such as India, China and Sri Lanka and in many other countries in South, Southeast and Eastern Asia due mainly to its healing capabilities. More recently, scientists initiated the chemical analyses of these medicinal plants, obtaining invaluable results. The latest addition to such investigations is studies on effects of herbal extracts on different types of stem cells. An extensive summary of such reported studies is presented in this chapter, mainly categorizing these into proliferation stimulatory effects on stem cells and inhibitory effects on cancer stem cells (CSCs), where both properties are beneficial in cell therapy procedures. At present, standardizing the products and limited knowledge on the mechanisms of action and pathways of these have critically limited the use of herbal extracts in therapeutics. However, we believe that in the near future scientists would be focusing on herbal remedies to replace the use of synthetic stimulants and cancer drugs to overcome the disadvantages of these, such as toxicity, side effects and exorbitant costs.

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Section: Effects Of Herbal Extracts On Human Stem Cells 21 Stimulatmentioning

confidence: 99%

Application of Herbal Medicine as Proliferation and Differentiation Effectors of Human Stem Cells

Udagama¹,

Udalamaththa²

2019

Herbal Medicine

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“…The name “aplastic anemia” does not appear in the ancient Chinese classics, whose clinical manifestations tend to be “consumptive disease” or “hemorrhagic syndrome” in traditional Chinese concepts [ 18 ]. In the 1950s, AA was thought to be a deficiency of Qi and blood according to the clinical manifestations of the patients [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Medication Regularity of Traditional Chinese Medicine in the Treatment of Aplastic Anemia Based on Data Mining

Dong

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. Aplastic anemia (AA) is an uncommon disease, characterized by pancytopenia and hypocellular bone marrow, but it is common in the blood system. The medication rules of traditional Chinese medicine (TCM) in the treatment of AA are not clear, for which it is worth exploring the medication rules by data mining methods. Methods. This study used SPSS Modeler 18.0 and SPSS statistics to analyze the cases of AA from Zhejiang Provincial Hospital of Chinese Medicine (ZJHCM) from March 1, 2019, to March 1, 2022. Data mining methods, including frequency analysis, cluster analysis, and association rule learning, were performed in order to explore the medication rules for AA. Results. (1) A total of 859 prescriptions, which met the inclusion criteria, consisted of 255 herbs. In descending order of the frequency of herbal medicine, we have Danggui, Huangqi, Shudihuang, Fuling, Gancao, Shanyao, Shanzhuyu, Baizhu, Dangshen, and Xianhecao. (2) Frequency analysis of herb properties: the Four Qi of 255 kinds of TCMs are mainly warm and neutral medicines. The Five Flavors are mainly sweet medicines, followed by bitter medicines. The main meridians are the liver, spleen, and kidney. (3) Clustering of medications: TCMs with the top 20 frequencies are classified into 9 groups by cluster analysis. (4) Association rule analysis of high-frequency herbs: using the Apriori algorithm, the results showed that there were 3 herb pairs with support of over 0.3 and 12 herb pairs with confidence above 0.85. Conclusion. The basic pathogenesis of AA (Sui Lao) is spleen and kidney essence deficiency, Qi deficiency, and blood stasis. The main herbs have warm and neutral properties, sweet tastes, and liver, spleen, and kidney meridian tropisms, whose purpose is to tonify the kidney and invigorate the spleen, tonify Qi, and promote blood circulation.

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“…We previously reported it could improve adhesion molecules expression levels of bone marrow mesenchymal stem cells (BMSCs) in AA patients [ 8 , 9 ]. Besides treatment with the kidney-reinforcing, blood-activating, and stasis-removing herbals could reduce the rate of graft failure and treatment-related mortality and improve the rate of overall survival (OS) in severe AA patients with allogeneic hematopoietic stem cell transplantation (allo-HSCT) [ 10 ]. However, its underlying mechanism for AA treatment remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Bushen Jianpi Quyu Formula Alleviates Myelosuppression of an Immune-Mediated Aplastic Anemia Mouse Model via Inhibiting Expression of the PI3K/AKT/NF-κB Signaling Pathway

Shen

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Bushen Jianpi Quyu Formula (BSJPQYF), an experienced formula, has been used to treat aplastic anemia (AA) more than three decades. To determinate the effect of BSJPQYF on AA, we constructed an immune-mediated AA mouse model. All mice were divided into four groups: control, model, low dose (0.85 g/mL), and high dose (1.7 g/mL BSJPQYF) group. They were administered with different concentrations of BSJPQYF or normal saline for 14 days. Besides, components of BSJPQYF were analyzed by electrospray ionization and mass spectrometry (ESI-MS). Subsequently, mouse peripheral blood and femurs were collected, and bone marrow mesenchymal stem cells (BMSCs) were isolated by fluorescence-activated cell sorting (FACS). Among them, tumor necrosis factor-α (TNF-α), transforming growth factor-β (TGF-β), and interferon-γ (IFN-γ) were measured by ELISA assay, PI3K, AKT, p-AKT, NF-κB, p-NF-κB, TNF-α, and cleaved caspase-3 proteins were detected by western blot. Compared with standard compounds, we identified three compounds of BSJPQYF, namely, icariin, kaempferol and tanshinone iia, as potentially effective compounds for the treatment of AA. Through an in vivo study, we found the administration of BSJPQYF in high dose for 14 days could significantly increase peripheral blood count and bone marrow (BM) cells, meanwhile decrease TNF-α, TGF-β, and IFN-γ levels. Besides, it could suppress the protein expression of PI3K and the phosphorylation of AKT and NF-κB to restrict the protein expression of TNF-α, eventually reduce the protein expression of cleaved caspase-3. This study demonstrated the therapeutic effects of BSJPQYF in AA, which could alleviate myelosuppression through inhibiting the expression of the PI3K/AKT/NF-κB signaling pathway.

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Combined use of Chinese medicine with allogeneic hematopoietic stem cell transplantation for severe aplastic anemia patients

Abstract: Treatment with the KBS formulation may reduce the rate of graft failure and treatment-related mortality and improve the rate of OS in SAA patients with allo-HSCT.

Cited by 8 publications

References 18 publications

Application of Herbal Medicine as Proliferation and Differentiation Effectors of Human Stem Cells

Application of Herbal Medicine as Proliferation and Differentiation Effectors of Human Stem Cells

Medication Regularity of Traditional Chinese Medicine in the Treatment of Aplastic Anemia Based on Data Mining

Bushen Jianpi Quyu Formula Alleviates Myelosuppression of an Immune-Mediated Aplastic Anemia Mouse Model via Inhibiting Expression of the PI3K/AKT/NF-κB Signaling Pathway

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