Combining Protein-Shelled Platinum Nanoparticles with Graphene to Build a Bionanohybrid Capacitor

San, Boi Hoa; Kim, Jang Ah; Kulkarni, Atul; Moh, Sang Hyun; Dugasani, Sreekantha Reddy; Subramani, Vinod Kumar; Thorat, Nanasaheb D.; Lee, Hyun Ho; Park, Sungha; Kim, Taesung; Kim, Kyeong Kyu

doi:10.1021/nn503178t

Cited by 17 publications

(26 citation statements)

References 62 publications

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“…Conjugation of biomolecules (e.g., DNA, proteins and peptides) to inorganic nanoparticles (NPs) opened up a broad range of exciting research in photonics, 1,2 biocatalysis, 1,3–5 bioelectronics, 1,2,6 biosensors, 1–3 drug delivery, 7,8 and gene regulation. 9–11 NPs used in drug and gene delivery are particularly attractive, since their small size allows for tissue penetration as well as elimination, while still affording a high number of targeting moieties and bioactive molecules on NP surfaces.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle Assembly and Gelatin Binding Mediated by Triple Helical Collagen Mimetic Peptide

San

Tarbet

et al. 2016

ACS Appl. Mater. Interfaces

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Peptide-conjugated nanoparticles (NPs) have promising potential for applications in biosensing, diagnosis, and therapeutics because of their appropriate size, unique self-assembly, and specific substrate-binding properties. However, controlled assembly and selective target binding are difficult to achieve with simple peptides on NP surfaces because high surface energy makes NPs prone to self-aggregate and adhere nonspecifically. Here, we report the self-assembly and gelatin binding properties of collagen mimetic peptide (CMP) conjugated gold NPs (CMP-NPs). We show that the orientation of CMPs displayed on the NP surface can control NP assembly either by promoting or hindering triple helical folding between CMPs of neighboring NPs. We also show that CMP-NPs can specifically bind to denatured collagen by forming triple-helical hybrids between denatured collagen strands and CMPs, demonstrating their potential use for detection and selective removal of gelatin from protein mixtures. CMP conjugated NPs offer a simple and effective method for NP assembly and for targeting denatured collagens with high specificity. Therefore, they may lead to new types of functional nanomaterials for detection and study of denatured collagen associated with diseases characterized by high levels of collagen degradation.

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Section: Introductionmentioning

confidence: 99%

Nanoparticle Assembly and Gelatin Binding Mediated by Triple Helical Collagen Mimetic Peptide

San

Tarbet

et al. 2016

ACS Appl. Mater. Interfaces

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“…PepA (PDB ID 3KL9) structure: (A) PepA surface presentation, (B) PepA interior surface, (C) GFET device with PepA-PtNP schematic, (D) PepA–PtNP biocapacitor schematic. Reprinted from ref . Copyright 2014 American Chemical Society.…”

Section: Conductive Composite Biopolymersmentioning

confidence: 99%

Conductive Polymers: Opportunities and Challenges in Biomedical Applications

et al. 2018

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Research pertaining to conductive polymers has gained significant traction in recent years, and their applications range from optoelectronics to material science. For all intents and purposes, conductive polymers can be described as Nobel Prize-winning materials, given that their discoverers were awarded the Nobel Prize in Chemistry in 2000. In this review, we seek to describe the chemical forms and functionalities of the main types of conductive polymers, as well as their synthesis methods. We also present an in-depth analysis of composite conductive polymers that contain various nanomaterials such as graphene, fullerene, carbon nanotubes, and paramagnetic metal ions. Natural polymers such as collagen, chitosan, fibroin, and hydrogel that are structurally modified for them to be conductive are also briefly touched upon. Finally, we expound on the plethora of biomedical applications that harbor the potential to be revolutionized by conductive polymers, with a particular focus on tissue engineering, regenerative medicine, and biosensors.

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“…This offered the potential for multichannel and broadband biosensors [70]. San et al reported the charge transport behavior of protein-shelled inorganic nanoparticles combined with graphene and demonstrated their possible application as flexible and biocompatible bionanoelectronic devices that can be integrated into bioelectric circuits for biomedical purposes [71]. Recently, regarding B14-S18 (drug combination), the development of medicines for complex diseases requires the development of drug combination therapies.…”

Section: Patent Hotspots and Frontsmentioning

confidence: 99%

A Study on Technology Competition of Graphene Biomedical Technology Based on Patent Analysis

2019

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Graphene, with high biocompatibility, physiological solubility and stability, has been reported as an emerging material for biomedical applications such as biosensors, drug delivery, and tissue engineering. Recently, identifying the technological competition (TC) of graphene biomedical technology has received worldwide attention from stakeholders. However, few studies have attached great importance to review the TC of this field by the analysis of patents. The main objective of this study is to develop a new and comprehensive method to investigate TC in a given technology field by conducting a patent review and then employing a patent roadmap to dig out the technology opportunity. The effectiveness of the approach is verified with the case study on graphene biomedical technology. Compared to previous research, this study makes the following important contributions. First, this study provides a new and systematic framework for the dynamic analysis of TC in a given technology field. It also extends the research perspectives of TC for industry, assignees, and technology, employs a patent roadmap to dig out technology opportunities, and enables stakeholders to understand TC from a dynamic perspective. Second, this study integrates patent analysis with a patent roadmap that has not appeared in existing methodologies of patent review. Third, it first introduces indicators (e.g., high value patent and competition position of top assignees) to the previous patent roadmap and provides a new methodology for patent roadmaps from a country level and assignee level. Finally, this study provides useful information for stakeholders interested in graphene biomedical technology, helps them to find new technology opportunities in this field, encourages them to determine the direction of future research, and has important significance for its application to diverse other emerging technologies.

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Combining Protein-Shelled Platinum Nanoparticles with Graphene to Build a Bionanohybrid Capacitor

Cited by 17 publications

References 62 publications

Nanoparticle Assembly and Gelatin Binding Mediated by Triple Helical Collagen Mimetic Peptide

Nanoparticle Assembly and Gelatin Binding Mediated by Triple Helical Collagen Mimetic Peptide

Conductive Polymers: Opportunities and Challenges in Biomedical Applications

A Study on Technology Competition of Graphene Biomedical Technology Based on Patent Analysis

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