Effects of Medical Male Circumcision (MC) on Plasma HIV Viral Load in HIV+ HAART Naïve Men; Rakai, Uganda

Kigozi, Godfrey; Musoke, Richard; Kighoma, Nehemiah; Watya, Stephen; Serwadda, David; Nalugoda, Fred; Kiwanuka, Noah; Wâbwire-Mângen, Fred; Tobian, Aaron A.R.; Makumbi, Fredrick; Galiwango, Ronald M.; Sewankambo, Nelson; Nkale, James; Nalwoga, Grace Kigozi; Anyokorit, Margaret; Lutalo, Tom; Gray, Ronald H.; Wawer, Maria J.

doi:10.1371/journal.pone.0110382

Cited by 3 publications

(4 citation statements)

References 7 publications

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“…As compared to other therapies, the efficacy of Antiretroviral therapy depends on strict adherence to the regimen. This poses the greatest challenges ever to many clients who initiated the therapy [14][15][16][17][18][19][20]. HIV is a pandemic infection that affects every part of the globe.…”

Section: Adherencementioning

confidence: 99%

“…Byrd et al [16] urged that adherence to Antiretroviral therapy (ART) is a powerful predictor of survival for People living with HIV/AIDS (PLWHIV) and that obtaining the full benefit from the therapy is a complex individual behavioral process influenced by many broader factors. Factors significantly associated with high ART adherence levels are adequate knowledge regarding the therapy, accessibility of the ART, and positive attitude towards the therapy [17,18].…”

Section: Adherencementioning

confidence: 99%

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Evaluation of the factors influencing adherence to ART in HIV/AIDS patients at Kampala International University Teaching Hospital Bushenyi District

Claire¹

2023

IDOSR JST

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Globally, there were an estimated 33 million people living with HIV by the end of 2007, and more than 25 million people since 1981 have died from AIDS. In 2007 there were 2.7 million new infections and 2 million HIV-related deaths. All these facts are attributed to the compromise of adherence to ART. Currently, there are an estimated 940,000 people (adults and children) living with HIV in Uganda but the adherence levels are hence posing a great challenge in the fight against the scourge. To assess factors influencing adherence to ART among HIV/AIDS clients at Kampala International University Teaching Hospital, a descriptive cross-sectional study design quantitative in nature was used to recruit 52 respondents for the study out of whom 52 questionnaires thus giving a response rate of 100%. 75% of the respondents strongly agreed that level of income may influence adherence to ART, 57% of the respondents agreed that drug hypersensitivity and side effects affect adherence to ART and 63.5% of the respondents agreed that clinic characteristics can impact adherence. The researcher concluded that client-related factors influencing adherence to ART include the client’s age, level of education, level of income, social support, co-morbidities, and patient’s belief about the effectiveness of ART. Therapy-related factors affecting adherence to ART include; polypharmacy, hypersensitivity, pill burden, and regimen complexity. Health system-related factors affecting adherence to ART include; clinic characteristics, selfmedication, lengthy wait before the next clinic visit, and the patient-provider relationship. Keywords: HIV/AIDS, ART, Adherence, Uganda, Hypersensitivity.

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Section: Adherencementioning

confidence: 99%

Section: Adherencementioning

confidence: 99%

Evaluation of the factors influencing adherence to ART in HIV/AIDS patients at Kampala International University Teaching Hospital Bushenyi District

Claire¹

2023

IDOSR JST

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“…A level of adherence that is greater than 95% (optimal adherence) suppresses viral replication and prevents the development of resistance and treatment failure. The clinical efficacy of antiretroviral therapy (ART) in suppressing the HIV virus and improving survival rates for those living with HIV has been well-documented [20][21][22][23][24][25]. However, successful antiretroviral therapy is dependent on sustaining high levels of adherence (correct dosage, taken on time, and in the correct way-either with or without food).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the factors that affect adherence to Anti-Retroviral Therapy in HIV-Positive Clients at Comboni Hospital Kyamuhunga Bushenyi Uganda

Alex¹

2023

IDOSR JST

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HIV is a global public health issue. In 2015 an estimated 36.7 million people were living with HIV including 1.8 million children. The majority of this number lives in low and middleincome countries. In the same year, 1.1 million people died of AIDS-related illnesses. Antiretroviral therapy (ART) has been shown to delay the progression of AIDS, resulting in a greater and more sustained virologic and immunologic response and improve survival. The study was a descriptive cross-sectional study, involving HIV patients on ART attending Comboni Hospital Kyamuhunga from 12st to 30th June 2017. The study aimed at understanding factors associated with poor adherence to ART among HIV-positive patients attending Comboni Hospital Kyamuhunga. Out of the 57 clients, 41(71.9%) had good adherence, and 16(28.10%) had poor adherence to Antiretroviral therapy. Forgetting accounted for (27)47% of the poor adherence, travel problems accounted for (14)25%, drug stock-outs (7)12%, and stigma, disclosure or privacy issues accounted for (9)16%. Despite results showing that most patients had good adherence, a significant number still had poor adherence to Antiretroviral therapy, the most common contributor to poor adherence being forgetting their doses and travel problems. There is a need to strengthen continuous monitoring of both adherence and correlating it with the clinical outcomes of the clients. This will create an interactive feedback mechanism that could lead to optimal clinical states and improved quality of life of clients. Keywords: HIV/AIDS, Antiretroviral therapy, Stigma, Drug stock out, Poor adherence, Comboni Hospital.

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“…To achieve this, the numbers of EMTCT health clinics were raised significantly. This allowed the people living in rural areas to have access to EMTCT, education, counseling and testing [10,11,12,13]. HIV transmission in Uganda is believed to be around 21 percent due to mother to child transmission [14,15,16,17].…”

Section: Introductionmentioning

confidence: 99%

Factors Affecting Health Workers in Implementation of EMTCT Services at Bushenyi Health Centre IV Bushenyi District

Olivia

2023

IDOSR JBBAF

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This study focused on factors affecting health workers in the implementation of EMTCT services at Bushenyi Health Centre IV. The objectives of the study were, to find out the health worker-based factors affecting health workers in the implementation of EMTCT services, to establish maternal-based factors affecting health workers in the implementation of EMTCT services and to assess mothers, knowledge in relation to participating in EMTCT services at Bushenyi health centre IV. The study was carried out at Bushenyi Health centre IV which is located in Bushenyi municipality in Bushenyi district which basically serves people from Bushenyi district with a few others from neighbouring districts. It was descriptive and crosssectional in which quantitative and qualitative methods of data collection were used and the study included health workers offering EMTCT services to the mother and mothers receiving EMTCT services who were around during the period of the study. The study found that 81.25%, of the health workers, had ever attained an EMTCT reinforcement workshop and only 3(18.75%) had not attended any workshop of that nature since they were transferred to Bushenyi health centre IV. The study found out that a bigger percentage of mothers at 93.75% have knowledge on various methods in which HIV can spread from the mother to the baby and only 6.25 percentage said she didn’t know of such ways and regarding knowledge on importance of VCT, study found out that all the 16 mothers who took part in the study knew that its of health importance to attend a VCT, but they didn’t have a detailed information about how EMTCT could help a mother who is found HIV positive. In conclusion, from the study health workers and mothers who participated in the study acknowledge that EMTCT is an essential service to the health of the mother and the baby, but is being hindered by fore mentioned challenges which are controllable if timely intervention is put in place. The following are therefore recommendations made for a better EMTCT service delivery, the government through the ministry of health should organize more workshops and short course training on EMTCT to enable health workers to acquire knowledge of the service also the government should sensitize people through public media to make use of EMTCT services from health facilities, the management of Bushenyi health centre IV should make outreaches for EMTCT services to mothers who may be able to come to the health facility quite often, health workers should always do follow up on their EMTCT clients so as to reduce the number of defaulters and lastly pregnant mothers should be encouraged to attend ANC services in which those who need EMTCT services can be identified. Keywords: EMTCT services, health workers, Pregnant mothers, HIV positive, Health facility

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Effects of Medical Male Circumcision (MC) on Plasma HIV Viral Load in HIV+ HAART Naïve Men; Rakai, Uganda

Cited by 3 publications

References 7 publications

Evaluation of the factors influencing adherence to ART in HIV/AIDS patients at Kampala International University Teaching Hospital Bushenyi District

Evaluation of the factors influencing adherence to ART in HIV/AIDS patients at Kampala International University Teaching Hospital Bushenyi District

Evaluation of the factors that affect adherence to Anti-Retroviral Therapy in HIV-Positive Clients at Comboni Hospital Kyamuhunga Bushenyi Uganda

Factors Affecting Health Workers in Implementation of EMTCT Services at Bushenyi Health Centre IV Bushenyi District

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