Case 3: An eight-month-old boy with failure to thrive

Human, Andrea; Eltobgy, Kamal; Beck, Carolyn E

doi:10.1093/pch/19.9.463

Cited by 1 publication

(3 citation statements)

References 3 publications

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“…The clinical manifestations of PMA match with those of other pediatric brain tumors including developmental delay and altered level of consciousness, besides hydrocephalus and generalized weakness along with focal neurological symptoms. Endocrine dysfunction and visual impairment such as nystagmus have been described as a pathognomonic sign in 55% of cases [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…It may be an outcome of diverse disorders such as nervous anorexia; absorption issues (Crohn's or celiac disease …); or any other chronic illness. Subsequently, an uncommon trouble should be suspected if dietary and behavioral interventions have been useless [ 14 ]. In fact, brain tumors can be responsible for the diencephalic syndrome including optic and hypothalamic astrocytomas.…”

Section: Discussionmentioning

confidence: 99%

“…Laboratory investigations embracing electrolyte levels, complete blood count, renal function panel, liver parameters, and hormonal assay were normal: FSH (follicle-stimulating hormone): 0.32 mUI/ml (1.5-14), LH (luteinizing hormone): 0.16 mUI/ml (1.2-10), testosterone: 0.078 ng/ml, 8 AM cortisol: 18.5 ug/dl (3.7-19.4), ultrasensitive TSH (ultrasensitive thyroid-stimulating hormone): 2.59 mUI/l (0.27-4.2), and FT4 (free thyroxine): 21.8 pmol/l (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). Levels of AFP (alpha-fetoprotein) (0-7) and HCG (human chorionic gonadotropin) (0-7) were also within normal ranges: 1.2 mUI/l and 6.82 ng/ml, respectively.…”

Section: Case Reportmentioning

confidence: 99%

See 2 more Smart Citations

Failure to Thrive Revealing a Pilomyxoid Astrocytoma: An Uncommon Case Report with Literature Review

Benyakhlef

Tahri

Khlifi

et al. 2021

Case Reports in Pediatrics

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Pilomyxoid astrocytoma (PMA) is a freshly described figure of low-grade neoplasms encountered in early childhood. Nevertheless, its precise classification by the World Health Organization (WHO) is still debatable. Making an exact diagnosis relies on histological and immunohistochemical pathognomonic features with specific radiological findings. PMA behaves aggressively with a shorter progression-free survival, and its management is unfortunately still arguable. We describe a rare case of PMA involving the suprasellar region who displays symptoms consistent with diencephalic syndrome. The diagnosis was made by magnetic resonance imaging (MRI) focused on the hypothalamic-pituitary axis, and the patient underwent a subtotal tumor resection combined with chemotherapy. Diagnosis of brain tumors should be kept in mind in young children with generalized and severe unexplained loss of subcutaneous fat with failure to thrive after ruling out classical causes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%