TGF-β1, Ghrelin, Neurexin, and Neuroligin are Predictive Biomarkers for Postoperative Prognosis of Laparoscopic Surgery in Children with Hirschsprung Disease

Xiao, Shangjie; Zhu, Xiaohui; Yang, Wei; Ge, Wuping; Zhang, Ying; He, Qiuming; Xia, Huimin

doi:10.1007/s12013-014-0338-1

Cited by 5 publications

(5 citation statements)

References 33 publications

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“…The analysis in the present study also demonstrated that NLGN1 mRNA and protein expression was increased in CRC. Interestingly, similar to what was observed in the previous study [ 25 ], ganglion cells had positive NLGN1 protein expression in the present study. Moreover, the patients with perineural invasion had significantly higher NLGN1 expression than those without perineural invasion.…”

Section: Discussionsupporting

confidence: 93%

“…NLGN1 and glutamate were co-expressed highest to lowest in the ganglionic, transitional and aganglionic segments. Furthermore, Xiao et al [ 25 ] found that decreasing expressions of NLGN1 proteins induced the dysfunction of ganglion cells in distal intestinal canal, which is associated with poor prognosis of children patients with Hirschsprung’s disease after operation.…”

Section: Discussionmentioning

confidence: 99%

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Upregulated NLGN1 predicts poor survival in colorectal cancer

Wang

Yang

et al. 2021

BMC Cancer

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Background Neuroligin1 (NLGN1) is a main component of excitatory glutamatergic synapses complex and is important for synapse assembly and function. The clinical value of NLGN1 in colorectal cancer (CRC) is not clear. Methods We obtained the expression data of 1143 CRC patients from 3 independent Gene Expression Omnibus (GEO) datasets (GSE32323, GSE24551, GSE39582) and The Cancer Genome Atlas (TCGA) to make the comparison of the NLGN1 expression level between CRC tissues and matched noncancerous tissues, and to evaluate its value in predicting survival of CRC patients. At the protein level, these results were further confirmed by immunohistochemical staining of 52 CRC samples in our own centre. Finally, the function of NLGN1 was explored by gene set enrichment analysis (GSEA). Results Increased mRNA and protein levels of NLGN1 expression were associated with worse overall survival or recurrence-free survival in CRC patients from 2 GEO datasets, the TCGA database, and our cohort. In addition, multivariate regression analysis showed that NLGN1 was an independent poor prognostic factor of survival in patients with CRC in TCGA database (OR = 2.524, P = 0.010). Functional analysis revealed that NLGN1 was correlated with function involving the Hedgehog signaling pathway, mismatch repair process, and some material metabolism processes. Conclusions This study is the first to implicate and verify NLGN1 as a new poor prognostic marker for CRC.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Upregulated NLGN1 predicts poor survival in colorectal cancer

Wang

Yang

et al. 2021

BMC Cancer

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“…The analysis in the present study also demonstrated that NLGN1 mRNA and protein expression was increased in CRC. Interestingly, similar to what was observed in the previous study [25], ganglion cells had positive NLGN1 protein expression in the present study. Moreover, the patients with perineural invasion had signi cantly higher NLGN1 expression than those without perineural invasion.…”

Section: Discussionsupporting

confidence: 93%

Upregulated NLGN1 predicts poor survival in colorectal cancer

Qian

Wang

Yang

et al. 2021

Preprint

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Background: Neuroligin1 (NLGN1) is a main component of excitatory glutamatergic synapses complex and is important for synapse assembly and function. The clinical value of NLGN1 in colorectal cancer (CRC) is not clear. Methods: We obtained the expression data of 1143 CRC patients from 3 independent Gene Expression Omnibus (GEO) datasets (GSE32323, GSE24551, GSE39582) and The Cancer Genome Atlas (TCGA) to make the comparison of the NLGN1 expression level between CRC tissues and matched noncancerous tissues, and to evaluate its value in predicting survival of CRC patients. At the protein level, these results were further confirmed by immunohistochemical staining of 52 CRC samples in our own centre. Finally, the function of NLGN1 was explored by gene set enrichment analysis (GSEA). Results: Increased mRNA and protein levels of NLGN1 expression were associated with worse overall survival or recurrence-free survival in CRC patients from 2 GEO datasets, the TCGA database, and our cohort. In addition, multivariate regression analysis showed that NLGN1 was an independent poor prognostic factor of survival in patients with CRC in TCGA database (OR = 2.524, P = 0.010). Functional analysis revealed that NLGN1 was correlated with function involving the Hedgehog signaling pathway, mismatch repair process, and some material metabolism processes. Conclusions: This study is the first to implicate and verify NLGN1 as a new poor prognostic marker for CRC.

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“…In total, 22 studies reported on paralytic ileus and entailed 1,332 patients and 120 events of paralytic ileus [ 35 , 42 , 46 , 48 , 49 , 51 , 61 , 65 , 81 , 82 , 96 , 98 , 100 , 103 , 109 , 112 , 114 , 115 , 132 , 151 , 153 , 155 ]. The pooled proportion of total paralytic ileus was 0.07 (95%-CI: 0.05–0.11; I 2 =71%, p≤0.01).…”

Section: Resultsmentioning

confidence: 99%

The incidence of different forms of ileus following surgery for abdominal birth defects in infants: a systematic review with a meta-analysis method

Schattenkerk

Musters

Nijssen

et al. 2021

Innovative Surgical Sciences

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Objectives Ileus following surgery can arise in different forms namely as paralytic ileus, adhesive small bowel obstruction or as anastomotic stenosis. The incidences of these different forms of ileus are not well known after abdominal birth defect surgery in infants. Therefore, this review aims to estimate the incidence in general between abdominal birth defects. Content Studies reporting on paralytic ileus, adhesive small bowel obstruction or anastomotic stenosis were considered eligible. PubMed and Embase were searched and risk of bias was assessed. Primary outcome was the incidence of complications. A meta-analysis was performed to pool the reported incidences in total and per birth defect separately. Summary This study represents a total of 11,617 patients described in 152 studies of which 86 (56%) had a follow-up of at least half a year. Pooled proportions were calculated as follows; paralytic ileus: 0.07 (95%-CI, 0.05–0.11; I 2=71%, p≤0.01) ranging from 0.14 (95% CI: 0.08–0.23) in gastroschisis to 0.05 (95%-CI: 0.02–0.13) in omphalocele. Adhesive small bowel obstruction: 0.06 (95%-CI: 0.05–0.07; I 2=74%, p≤0.01) ranging from 0.11 (95% CI: 0.06–0.19) in malrotation to 0.03 (95% CI: 0.02–0.06) in anorectal malformations. Anastomotic stenosis after a month 0.04 (95%-CI: 0.03–0.06; I 2=59%, p=0.30) ranging from 0.08 (95% CI: 0.04–0.14) in gastroschisis to 0.02 (95% CI: 0.01–0.04) in duodenal obstruction. Anastomotic stenosis within a month 0.03 (95%-CI 0.01–0.10; I 2=81%, p=0.02) was reviewed without separate analysis per birth defect. Outlook This review is the first to aggregate the known literature in order approximate the incidence of different forms of ileus for different abdominal birth defects. We showed these complications are common and the distribution varies between birth defects. Knowing which birth defects are most at risk can aid clinicians in taking prompt action, such as nasogastric tube placement, when an ileus is suspected. Future research should focus on the identification of risk factors and preventative measures. The incidences provided by this review can be used in those studies as a starting point for sample size calculations.

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TGF-β1, Ghrelin, Neurexin, and Neuroligin are Predictive Biomarkers for Postoperative Prognosis of Laparoscopic Surgery in Children with Hirschsprung Disease

Cited by 5 publications

References 33 publications

Upregulated NLGN1 predicts poor survival in colorectal cancer

Upregulated NLGN1 predicts poor survival in colorectal cancer

Upregulated NLGN1 predicts poor survival in colorectal cancer

The incidence of different forms of ileus following surgery for abdominal birth defects in infants: a systematic review with a meta-analysis method

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