Relationship between renal apparent diffusion coefficient values and glomerular filtration rate in infants with congenital hydronephrosis

Lin, Fuchun Joseph; Li, Zhiyong; Gan, Yong; Sun, Lianwen; Fang, Diangang; Xiang, Kui; Liu, Lei

doi:10.5582/bst.2014.01110

Cited by 8 publications

(6 citation statements)

References 22 publications

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“…Fetal DW‐MRI images have been used for the assessment of various kidney diseases, such as solid renal tumors, multicystic dysplastic kidney, renal venous thrombosis, or the characterization of unilateral urinary tract dilatation with difficulty in screening the contralateral kidney . Recently, DWI with ADC determination has been used to evaluate the single renal function of infants with congenital hydronephrosis . They found a positive correlation between ADC values and the glomerular filtration function, which demonstrates that the ADC can reflect the filtration function of hydronephrotic kidneys.…”

Section: Discussionmentioning

confidence: 99%

“…Considerable attention has been given to investigate renal diffusion‐weighted magnetic resonance imaging (DW‐MRI), and some recent studies have demonstrated that DWI has potential clinical value in evaluating some renal diseases . Few authors have attempted to assess renal function based on ADC values measured by DW‐MRI . In children with congenital hydronephrosis, Lin et al found a positive correlation between the renal ADC and the split renal glomerular filtration rate (GFR).…”

Section: Introductionmentioning

confidence: 99%

“…Few authors have attempted to assess renal function based on ADC values measured by DW‐MRI . In children with congenital hydronephrosis, Lin et al found a positive correlation between the renal ADC and the split renal glomerular filtration rate (GFR). Studies focusing on the renal diffusion of fetuses are scarce, and currently, no study has been found with regard to using renal ADC values to explore the kidneys of fetuses with suspected PUV.…”

Section: Introductionmentioning

confidence: 99%

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Predicting postnatal renal function of prenatally detected posterior urethral valves using fetal diffusion‐weighted magnetic resonance imaging with apparent diffusion coefficient determination

et al. 2017

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Here, it seems that diffusion-weighted magnetic resonance imaging with ADC determination could be useful in accurately evaluating fetal kidneys in PUV and predicting renal function. It may be an additional, non-invasive method when biologic and sonographic findings are inconclusive, especially in the case of oligohydramnios. Further studies are needed to confirm our data. © 2017 John Wiley & Sons, Ltd.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Predicting postnatal renal function of prenatally detected posterior urethral valves using fetal diffusion‐weighted magnetic resonance imaging with apparent diffusion coefficient determination

et al. 2017

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“…However, some studies on diffusivity in renal pathology in adults and children show that the diffusivity of the renal parenchyma in newborns with congenital hydronephrosis is lower than of those fetuses with healthy kidneys [32]. ADC-values of healthy fetuses are lower than in newborns [24,32] which can be explained by the fact that the renal perfusion and the GFR are lower in fetuses and increase after birth [30], while the glomerular density is already determined at birth and thus has no influence on the diffusivity. In this study, it was shown that there is a negative correlation between the ADC-values with b-values of 700 and 800 s/ mm ² and the GA, which was significant for a b-value of 700 s/mm ² .…”

Section: Renal Imagingmentioning

confidence: 99%

Comparison of amniotic fluid volumetry between fetal sonography and MRI - Correlation to MR diffusion parameters of the fetal kidney

Moschos¹,

Güllmar²,

Fiedler³

et al. 2017

Birth Defect

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Objective: Determine whether amniotic fluid volume (AFV) determination by magnetic resonance imaging (MRI) can be compared with ultrasound based amniotic fluid index (AFI) and whether diffusion weighted imaging (DWI) of the fetal kidneys can be used as surrogate marker for the assessment of AFV and fetal kidney function. Methods:In the period from August 2013 to September 2014 prospective evaluation of AFV based on TRUFI MRI in 2 spatial planes (AFVMRI) and ultrasound based AFI. Inclusion criteria for the evaluation were: 1) Full image of the fetus (including AF and placenta) in an MR-study in at least two planes (sagittal and coronal), 2) Layer thickness 8 mm, 3) DWI-images of the fetal kidney in two planes (sagittal and transverse to the fetus). ROI analysis of the ADC values in normal kidneys and in pathological fetal kidneys (CAKUT) as well as the correlation of AFVMRI vs. AFI, renal volume and ADC were performed. Results:The correlation between AFI (13.60 ± 2.46 cm) and AFVMRI (579 ± 353 mL) was 0.69 (p=0.03). There was no significant correlation between AFVMRI and kidney volume, between AFVMRI and ADC700 and ADC800. The B700-ADC values of fetuses with CAKUT (n=14) were considerably higher than the values in fetuses with healthy kidneys. Conclusion:Compared to AFI, AFVMRI showed higher accuracy, but was associated with higher time consumption. Thus it cannot be routinely recommended for the purpose of AFV-determination alone. MRI can be used to establish a relationship between kidney diffusion parameters, renal volume, GA and AFV in fetuses with CAKUT.

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“…Diffusion-weighted imaging (DWI) is a technique used to display and measure the diffusion of water molecule. It reflects the Brownian motion of water molecules in the tissues [6]. Because of the kidney's task in water reabsorption and concentration dilution, water transport is considered the main renal function.…”

Section: Introductionmentioning

confidence: 99%

DWI as a biomarker of renal function in children with CKD: what is the potential?

Emad‐Eldin

Yadav

Galal

et al. 2020

Egypt J Radiol Nucl Med

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Background: Evaluation of renal microstructure is pivotal for diagnosing and monitoring chronic renal disease. DWI has been proved to be practicable and reliable examination for the assessment of renal function and parenchymal damage in some renal diseases. Our aim is to appraise DWI sequence and ADC measurement as a potential tool of renal function assessment as well as establishing a possible relationship between the different CKD stages and the renal parenchymal ADC values changes. Results: Regarding the cause of CKD, nine patients (45%) had glomerulonephritis, 5 patients (25%) had hemolytic uremic syndrome, 2 patients (10%) had lupus nephritis, 2 patients (10%) had nepheronophthisis, and 1 patient (1.5%) had infantile nepherosis, whereas the cause of CKD was unknown in 1 patient (1.5%). The stages of CKD were classified according to KIDGO guidelines: 6 patients (30%) were stage 1, 4 patients (20%) were stage 2, 3 patients (15%) were stage 3, 2 patients (10%) were stage 4, and 5 patients (25%) were stage 5. The patients' group (group A) had a mean ADC value (1.85 × 10 −3 ± 0.24) which was significantly lower than that of the control group (group B) (2.21 × 10 −3 ± 0.12). As for the correlation between stage of CKD and ADC, we found it to be a moderate negative one with r' value of − .655 and a significant p value of < 0.001. Conclusion: DWI is recognized as a promising imaging tool that can take part in the assessment of the morphological and functional changes in diffuse renal parenchymal disease, hence playing an important role in the early diagnosis and staging of chronic kidney disease.

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Relationship between renal apparent diffusion coefficient values and glomerular filtration rate in infants with congenital hydronephrosis

Cited by 8 publications

References 22 publications

Predicting postnatal renal function of prenatally detected posterior urethral valves using fetal diffusion‐weighted magnetic resonance imaging with apparent diffusion coefficient determination

Predicting postnatal renal function of prenatally detected posterior urethral valves using fetal diffusion‐weighted magnetic resonance imaging with apparent diffusion coefficient determination

Comparison of amniotic fluid volumetry between fetal sonography and MRI - Correlation to MR diffusion parameters of the fetal kidney

DWI as a biomarker of renal function in children with CKD: what is the potential?

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