Reply

Adler-Shohet, Felice C.; Low, Julie; Carson, Michael P.; Girma, Haimanot; Singh, Jasjit

doi:10.1097/inf.0000000000000437

Cited by 1 publication

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[1][2][3][4] Similar to most antibiotics, the drug has concentration dependent bacteria killing properties. [1][2][3][4] Similar to most antibiotics, the drug has concentration dependent bacteria killing properties.…”

Section: Introductionmentioning

confidence: 99%

“…Levofloxacin (Levo), also known as Levaquin or Tavanic, is a second generation fluoroquinolone widely used against infections caused by both gram negative and gram positive bacteria. [1][2][3][4] Similar to most antibiotics, the drug has concentration dependent bacteria killing properties. Thus, discussions are on-going concerning whether it should be administered as single high dosage or multiple low dosages.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Droplet based microfluidics: spectroscopic characterization of levofloxacin and its SERS detection

Hidi

Jahn

Weber

et al. 2015

Phys. Chem. Chem. Phys.

View full text Add to dashboard Cite

Levofloxacin (Levo), a second generation fluoroquinolone, has both clinical and environmental relevance. Therefore, the implementation of fast, robust and cost effective techniques for its monitoring is required. Here, its spectroscopic characterization and its detection in aqueous environment were carried out using surface enhanced Raman spectroscopy combined with droplet based microfluidics. The Levo molecule interacts with the silver nanoparticles via the carboxylate group and it adopts an upright or slightly tilted orientation. Furthermore, it is shown that the presence of Cl(-) ions has a strong influence on the enhancement efficiency of the Raman signal of the target molecule. Thus, for the determination of the limit of detection (LOD) the measurements were carried out in the absence of any electrolytes. The estimated LOD is ∼0.8 μM and the linear dynamic window ranges between 1-15 μM. These results were achieved after the normalization of the SERS signal to the Raman mode at 230 cm(-1). This band was attributed to the ν(Ag-O) stretching and it accounts for the Levo molecules in the first layer on the Ag nanoparticles.

show abstract