Neuroimaging and psychophysiological investigation of the link between anxiety, enhanced affective reactivity and interoception in people with joint hypermobility

Mallorquí‐Bagué, Núria; Garfinkel, Sarah N.; Engels, Miriam; Eccles, Jessica; Pailhez, Guillem; Bulbena, Antonio; Critchley, Hugo D.

doi:10.3389/fpsyg.2014.01162

Cited by 54 publications

(74 citation statements)

References 37 publications

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“…Respondents rate each item on a six‐point scale ranging from 0 ( never ) to 5 ( always ), with lower scores reflecting greater interoception deficits. Strong evidence of the MAIA's convergent and discriminant validity and adequate‐to‐strong reliability has been demonstrated in previous research (Mallorquí‐Bagué et al., ; Mehling et al., ).…”

Section: Methodssupporting

confidence: 60%

Examination of interoception along the suicidality continuum

2018

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Section: Methodssupporting

confidence: 60%

Examination of interoception along the suicidality continuum

2018

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“…Celletti et al [] observed that patients with a JHS/hEDS had high scores of kinesiophobia. JHS/hEDS patients also have hyperalgesia [Castori, ], enhanced interoception [Mallorqui‐Bague et al, ; Bulbena et al, ], and a tendency toward a somatosensory amplification [Baeza‐Velasco et al, ]. These aspects related to increased perception and/or reduced tolerance of pain [Feuerstein and Beattie, ; Pollatos et al, ], might influence the pain experience.…”

Section: Literature Reviewmentioning

confidence: 99%

Psychiatric and psychological aspects in the Ehlers–Danlos syndromes

Bulbena¹,

Baeza-Velasco²,

Bulbena-Cabré³

et al. 2017

American J of Med Genetics Pt C

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109

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There is increasing amount of evidence pointing toward a high prevalence of psychiatric conditions among individuals with hypermobile type of Ehlers-Danlos syndrome (JHS/hEDS). A literature review confirms a strong association between anxiety disorders and JHSh/hEDS, and there is also limited but growing evidence that JHSh/ hEDS is also associated with depression, eating, and neuro-developmental disorders as well as alcohol and tobacco misuse. The underlying mechanisms behind this association include genetic risks, autonomic nervous system dysfunction, increased exteroceptive and interoceptive mechanisms and decreased proprioception. Recent neuroimaging studies have also shown an increase response in emotion processing brain areas which could explain the high affective reactivity seen in JHS/hEDS. Management of these patients should include psychiatric and psychological approaches, not only to relieve the clinical conditions but also to improve abilities to cope through proper drug treatment, psychotherapy, and psychological rehabilitation adequately coupled with modern physiotherapy. A multidimensional approach to this "neuroconnective phenotype" should be implemented to ensure proper assessment and to guide for more specific treatments. Future lines of research should further explore the full dimension of the psychopathology associated with JHS/hEDS to define the nature of the relationship. © 2017 Wiley Periodicals, Inc.KEY WORDS: joint hypermobility; anxiety; psychopathology; neuroconnective phenotype; hypermobile Ehlers-Danlos syndrome Professor Antonio Bulbena, M.D., M.Sc, Ph.D., is the Chair of the Department of Psychiatry at the Autonoma University of Barcelona with clinical, academic, and administrative contributions particularly in the area of psychosomatic medicine and anxiety disorders, dementia, chocolate and carbohydrates, clinical measurement in psychiatry, phobias, seasonality, and biometeorology. Has recently developed the Neuroconnective Phenotype and has published numerous books, book chapters, and scientific articles in peer-reviewed journals.Carolina Baeza-Velasco, Ph.D., is a clinical psychology at the Paris Descartes University, with important contributions in the area of psychological assessment and treatment of patients with comorbid anxiety disorders and joint hypermobility among other conditions. Has published several articles about the psychological factors of EDS and related conditions. Andrea Bulbena-Cabre, M.D., M.Sc., is a Psychiatry Research Fellow at the Icahn School of Medicine at Mount Sinai/J. J. Peters Bronx VA Hospital. She has specialized in psychosomatic medicine and is currently studying the anxiety-joint hypermobility phenomena in bipolar and psychotic spectrum disorders. Other research interests include substance abuse, especially in synthetic cannabis and psychosis.Guillem Pailhez, M.D., Ph.D., is an Assistant Professor at the Department of Psychiatry at the Autonoma University of Barcelona, has devoted his career in the study of the interactions between mind and body ...

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“…Importantly, interoceptive awareness is ambiguous and can be associated with both deleterious and beneficial effects [5,8]. Maladaptive forms of IA characterized by hypervigilance and catastrophizing over body sensations are linked with clinical complaints, such as chronic pain [12], anxiety [13,14] and disordered eating [15]. However, healthy forms of IA characterized by appropriate attention regulation and acceptance can also be used to disengage from maladaptive thoughts and improve clinical symptoms, such as with pain and depression [16,17].…”

Section: Interoceptive Awareness and Psychological Well-beingmentioning

confidence: 99%

Holding the body in mind: Interoceptive awareness, dispositional mindfulness and psychological well-being

Hanley

Mehling

Garland

2017

Journal of Psychosomatic Research

103

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Objective Recent dialogue between Western and Eastern traditions has stimulated novel explorations of the relationship between mind and body. Many of these cross-cultural, mind-body dialogues have proven productive in identifying more adaptive forms of embodiment. Prior studies suggest that dispositional mindfulness (DM) and interoceptive awareness (IA) are associated but distinct, key constructs in mind-body approaches that are conceptualized in a variety of ways with imprecisely characterized relationship. The current study is a secondary data analysis that explores the relationship between scores on measures of IA and DM, examining multivariate networks of association between these constructs and addressing their relationship with scores on a measure of psychological well-being. Method Participants (n=478) were American adults completing measures of interoceptive awareness (as measured by the Multidimensional Assessment of Interoceptive Awareness; MAIA), dispositional mindfulness (as measured by the Five Facet Mindfulness Questionnaire; FFMQ), and psychological well-being (as measure by the Scales of Psychological Well-Being; SPWB) online. The average participant age was 36.44 (S.D.=12.17), and 57% were female. Results Correlational results from his study indicated that the IA scales and DM facets form two associative clusters. Canonical correlation analysis supported this finding, revealing that two primary networks of association exist between IA and DM, a Regulatory Awareness cluster and an Acceptance in Action cluster. Finally, hierarchical linear regression demonstrated that the self-report measures of IA and DM shared considerable variance, but also explained unique portions of the variance in psychological well-being. Conclusion This psychometric investigation demonstrates that IA and DM are tightly interwoven, partly overlapping constructs. Indeed, greater DM is strongly linked with greater IA. Additionally, both IA and DM appear to be independently associated with enhanced psychological well-being. Future research should investigate how mindfulness practices moderate IA for therapeutic implications.

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Neuroimaging and psychophysiological investigation of the link between anxiety, enhanced affective reactivity and interoception in people with joint hypermobility

Cited by 54 publications

References 37 publications

Examination of interoception along the suicidality continuum

Examination of interoception along the suicidality continuum

Psychiatric and psychological aspects in the Ehlers–Danlos syndromes

Holding the body in mind: Interoceptive awareness, dispositional mindfulness and psychological well-being

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