Improved osseointegration and interlocking capacity with dual acid‐treated implants: a rabbit study

Halldin, Anders; Jimbo, Ryo; Johansson, Carina B.; Gretzer, Christina; Jacobsson, Maritha

doi:10.1111/clr.12507

Cited by 8 publications

(24 citation statements)

References 30 publications

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“…33 It has been reported by Halldin et al that dual acid-etched implants with a reduced microtopography in height deviation, presented equivalent osseointegration compared to the commercially available fluoride-treated implants in a biomechanical investigation using rabbits. 34 Thus, it can be speculated that parameters other than the arithmetic average height deviation was altered in a manner that it stimulated osteogenesis for surface L.…”

Section: Discussionmentioning

confidence: 99%

The effect of controlled microrobotized blasting on implant surface texturing and early osseointegration

et al. 2015

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Surface topography modifications have become a key strategy for hastening the host-to-implant response to implantable materials. The present study evaluated the effect of three different carefully controlled surface texture patterns achieved through microrobotized blasting (controlled to high, medium and low roughness) relative to a larger scale blasting procedure (control) in early osseointegration in a canine model. Four commercially pure grade 2 titanium alloy implants (one of each surface) were bilaterally placed in the radii of six beagle dogs and allowed end points of 1 and 6 weeks in vivo. Following sacrifice, implants in bone were non-decalcified processed for bone morphologic and histometric (bone-to-implant contact; bone area fraction occupancy) evaluation. Surface topography was characterized by scanning electron microscopy and optical interferometry. Results showed initial osteogenic tissue interaction at one week and new bone in intimate contact with all implant surfaces at 6 weeks. At 1 and 6 weeks in vivo, higher bone-to-implant and bone area fraction occupancy were observed for the high texture pattern microrobotized blasted surface relative to others.

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Section: Discussionmentioning

confidence: 99%

The effect of controlled microrobotized blasting on implant surface texturing and early osseointegration

et al. 2015

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“…Also, the topography and chemistry of the surface properties can control the quantity and quality of adhered cells to the implant (Rosales-Leal et al, 2010, Logan and Brett, 2013). It has been reported that optimal surface roughness can lead to effective osseointegration (Halldin et al, 2014). This effect was due to increased osteoblast proliferation, differentiation and matrix protein production, e.g.…”

Section: Introductionmentioning

confidence: 99%

Low dose effect of bisphosphonates on hMSCs osteogenic response to titanium surface in vitro

et al. 2017

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Since the 1980s, titanium (Ti) implants have been routinely used to replace missing teeth. This success is mainly due to the good biocompatibility of Ti and the phenomenon of osseointegration, with very early events at implant placement being important in determining good osseointegration. However, enhancing implant performance with coatings such as hydroxyapatite (HA) and calcium phosphate has proved largely unsuccessful. Human mesenchymal stem cells (hMSCs) are the first osteogenic cells to colonise implant surfaces and offer a target for enhancing osseointegration. We previously reported that small doses of bisphosphonate (BP) may play an integral role in enhancing hMSC proliferation and osteogenic differentiation. The aim of this study is to investigate whether small doses of bisphosphonates enhance proliferation and osteogenic differentiation of hMSCs on Ti surfaces, to enhance bone osseointegration and to accelerate wound healing around the implant surface. Our data suggests that treating cells with small doses of BP (100 nM & 10 nM) induces significant hMSC stimulation of osteogenic markers including calcium, collagen type I and ALP compared to control group on titanium surfaces (P < 0.05). In addition, cell proliferation and migration were significantly enhanced on titanium surfaces (P < 0.05).

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“…The coordinates (x, y and z) from a representative patch of each of the three different (A, B and C) surfaces used in the study by Halldin et al [ 27 ] were extracted from interferometry measurements. Group A were blasted with coarse titanium particles thereafter treated in oxalic acid and hydrofluoric acid sequentially (CB-AT-I).…”

Section: Methodsmentioning

confidence: 99%

“…Group C implants were blasted with coarse titanium particles thereafter treated in hydrofluoric acid (CB-HF). The representative patches were selected to have surface average height values (S a ) close to the mean S a values of the implant in Halldin et al [ 27 ]. The x, y and z coordinates were imported into MATLAB (MATLAB 2013b, Mathworks Inc., USA) to calculate the average height values (S a [μm]), root-mean-square (S q [μm]), skewness (S sk [μm/μm]) and the root-mean-square of the surface slope (S dq [μm/μm]) of the selected patches [ 8 ].…”

Section: Methodsmentioning

confidence: 99%

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Simulation of the mechanical interlocking capacity of a rough bone implant surface during healing

et al. 2015

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BackgroundWhen an implant is inserted in the bone the healing process starts to osseointegrate the implant by creating new bone that interlocks with the implant. Biomechanical interlocking capacity is commonly evaluated in in vivo experiments. It would be beneficial to find a numerical method to evaluate the interlocking capacity of different surface structures with bone. In the present study, the theoretical interlocking capacity of three different surfaces after different healing times was evaluated by the means of explicit finite element analysis.MethodsThe surface topographies of the three surfaces were measured with interferometry and were used to construct a 3D bone-implant model. The implant was subjected to a displacement until failure of the bone-to-implant interface and the maximum force represents the interlocking capacity.ResultsThe simulated ratios (test/control) seem to agree with the in vivo ratios of Halldin et al. for longer healing times. However the absolute removal torque values are underestimated and do not reach the biomechanical performance found in the study by Halldin et al. which might be a result of unknown mechanical properties of the interface.ConclusionFinite element analysis is a promising method that might be used prior to an in vivo study to compare the load bearing capacity of the bone-to-implant interface of two surface topographies at longer healing times.

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Improved osseointegration and interlocking capacity with dual acid‐treated implants: a rabbit study

Cited by 8 publications

References 30 publications

The effect of controlled microrobotized blasting on implant surface texturing and early osseointegration

The effect of controlled microrobotized blasting on implant surface texturing and early osseointegration

Low dose effect of bisphosphonates on hMSCs osteogenic response to titanium surface in vitro

Simulation of the mechanical interlocking capacity of a rough bone implant surface during healing

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