Beneficial Impact of Sleep Extension on Fasting Insulin Sensitivity in Adults with Habitual Sleep Restriction

Abstract

In healthy adults who are chronically sleep restricted, a simple low cost intervention such as sleep extension is feasible and is associated with improvements in fasting insulin sensitivity.

Joint Consensus Statement of the American Academy of Sleep Medicine and Sleep Research Society on the Recommended Amount of Sleep for a Healthy Adult: Methodology and Discussion

“…Conversely, small uncontrolled studies have reported beneficial effects of sleep extension on glucose metabolism and appetite ratings in individuals who habitually curtail their sleep. 70,71 Numerous cross-sectional and longitudinal populationbased observational studies have assessed the relationships between sleep duration and diabetes, obesity, and the metabolic syndrome. Three meta-analyses of prospective studies on sleep duration and diabetes were identified.…”

Delaying time to first nocturnal void may have beneficial effects on reducing blood glucose levels

“…Possible mechanisms are sleep loss-induced changes in appetite-signaling hormones, altered responses of peripheral tissues to metabolic signals, and changes in energy intake and expenditure. Very recently, Leproult et al [29] have demonstrated that in young subjects [normal weight to overweight (BMI \ 30 kg/m 2 )], who were otherwise healthy but incurred the habitual restriction of sleep so common in students and working adults in modern society, extending sleep duration by no more than 1 h a day (duration of sleep was increased by 49 min using polysomnography and 44 min using actigraphy) was associated with improvement in surrogate measures of insulin sensitivity. Another recent study examining the effects of two nights of recovery sleep approximating 10 h (following four consecutive nights of severe sleep restriction to 4.5 h) was associated with resumption of normal insulin sensitivity in healthy young lean men [30].…”

Prospective analysis of the association of ambulatory blood pressure characteristics with incident chronic kidney disease

“…1). For the secondary incident CKD endpoint using the KDIGO definition, we analyzed the 440 individuals with information on both serum creatinine and urine albumin excretion at exams 1 and 3 who were without CKD at baseline (eGFR >60 ml/min per 1.73 m 2 and urine ACR <30 mg/g at exam 1) to determine the association of 24-h ABPM characteristics with incident CKD using the KDIGO definition [20]. In secondary analyses, we analyzed the association of 24-h ABPM characteristics with the rate of eGFR decline in all 644 participants with exams 1 and 3 serum creatinine values.…”