Carotid hemodynamics is associated with monocyte count determined by serum homocysteine level in patients with essential hypertension

Jotoku, Masanori; Okura, Takafumi; Miyoshi, Katsuhiko; Irita, Jun; Nagao, Tetsuhiko; Kukida, Masayoshi; Tanino, Akari; Kudo, Kayo; Enomoto, Daijiro; Pei, Zuowei; Higaki, Jitsuo

doi:10.3109/10641963.2014.972563

Cited by 2 publications

(1 citation statement)

References 40 publications

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“…Jotoku et al have shown a significant association between pulsatility index of the common carotid artery with cardiovascular risk factors, namely homocysteine and monocyte levels. Both of the latter parameters have been shown to be related to coronary plaque development and progression in acute myocardial infarction [21].…”

Section: Pulsatility Index In Atherosclerosis and Arterial Stenosismentioning

confidence: 99%

Clinical application of pulsatility index

Wielicka

Neubauer-Geryk

Kozera

et al. 2020

Medical Research Journal

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Pulsatility index (PI) is defined as the difference between the peak systolic flow and minimum diastolic flow velocity, divided by the mean velocity recorded throughout the cardiac cycle. It is a non-invasive method of assessing vascular resistance with the use of Doppler ultrasonography. It was first introduced in 1974 by Gosling and King and is also known as the Gosling Index. PI as a method of examining macrocirculation has a variety of clinical applications. For instance, in diabetic patients, it has been measured on the common carotid, middle cerebral or renal arteries to help predict complications such as cerebrovascular disease or nephropathy. In hypertensive patients, it has been used to assess complications and assess the chronicity of the disease. To our knowledge, despite the diverse use of this ultrasonographic parameter, there is a deficiency in reports that would comprehensively summarize its clinical applications. Based on our extensive review of the literature and the gathered information, we conclude that pulsatility index (PI) is an easy to obtain parameter with a broad range of both, research and clinical applications. It has been widely used in the assessment of macrocirculation in highly prevalent chronic medical conditions, such as hypertension, both type 1 and type 2 diabetes and thyroid disorders.

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Section: Pulsatility Index In Atherosclerosis and Arterial Stenosismentioning

confidence: 99%

Clinical application of pulsatility index

Wielicka

Neubauer-Geryk

Kozera

et al. 2020

Medical Research Journal

View full text Add to dashboard Cite

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The prevalence, relative risk factors and MTHFR C677T genotype of H type hypertension of the elderly hypertensives in Shanghai, China: a cross-section study

Qian

Cao

Zhang

et al. 2021

BMC Cardiovasc Disord

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Background H type hypertension is defined as homocysteine (Hcy) ≥ 10 μmol/L in combination with primary hypertension. Studies demonstrated that the existence of hyperhomocysteine (HHcy) in hypertensive exacerbates the poor outcome of cardiocerebral incidents. This study was to investigate the current epidemic situation of H type hypertension and determine the risk factors in order to find intervention targets for H type hypertensives. Methods We conducted a cross-sectional study using cluster sampling design in Shanghai, China from July 2019 and April 2020. 23,652 patients with primary hypertension were enrolled in this study. Their medical information was recorded, and the level of Hcy concentrations and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms were detected. Results In total, 22,731 of 23,652 patients were recorded. The mean age was 68.9 ± 8.6 y and 43% were men. 80.0% of the enrolled patients had H type hypertension. The frequency of allele T was 40.9%, and the proportions of the CC, CT, and TT genotypes were 36.1%, 46.0%, and 17.9%, respectively. Compared with the TT genotype, the plasma Hcy concentration levels were lower in patients with the CC/CT genotype (18.96 ± 13.48 μmol/L vs. 13.62 ± 5.20/14.28 ± 5.36, F = 75.04, p < 0.01). The risk for H type hypertension was higher in elderly people. Men had ~ 5.55-fold odds of H type hypertension compared with women. Patients with CT genotype and TT genotype had ~ 1.36- and ~ 2.76-fold odds of H type hypertension compared with those with CC genotype, respectively. Smoking and diabetes were not significantly associated with H type hypertension. Conclusions The prevalence of H type hypertension in patients with primary hypertension was 80.0%, which was higher than the 75% found in prior report in China. Age, gender, and MTHFR C677T polymorphisms rather than smoking and diabetes were independently associated with H type hypertension.

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Carotid hemodynamics is associated with monocyte count determined by serum homocysteine level in patients with essential hypertension

Cited by 2 publications

References 40 publications

Clinical application of pulsatility index

Clinical application of pulsatility index

The prevalence, relative risk factors and MTHFR C677T genotype of H type hypertension of the elderly hypertensives in Shanghai, China: a cross-section study

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