Once-weekly muscle endurance and strength training prevents deterioration of muscle oxidative function and attenuates the degree of strength decline during 3-week forearm immobilization

Homma, Toshiyuki; Hamaoka, Toshiyuki; Osada, Takuya; Murase, Norio; Kime, Ryotaro; Kurosawa, Yuko; Ichimura, Shiro; Esaki, Kazuki; Nakamura, Fumiko; Katsumura, Toshihito

doi:10.1007/s00421-014-3029-0

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…; Homma et al . ), may play a more prominent role in altering muscle oxidative capacity rather than ageing per se (Kent & Fitzgerald, ).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, a recent meta-analysis of 22 studies using PCr recovery kinetics to estimate muscle oxidative capacity revealed that the muscle oxidative capacity is actually higher or does not differ in old compared to young adults for muscles of the upper extremity and the ankle plantarflexor and dorsiflexor muscles . The disparate findings between muscle groups and across studies on the knee extensors suggests that other factors, such as the patterns of use and disuse of the muscle (Kitahara et al 2003;Larsen et al 2009;Homma et al 2015), may play a more prominent role in altering muscle oxidative capacity rather than ageing per se .…”

Section: Is a Reduced Muscle Oxidative Capacity An Obligatory Consequmentioning

confidence: 99%

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Bioenergetic basis for the increased fatigability with ageing

Sundberg

Prost

Fitts

et al. 2019

The Journal of Physiology

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Key points The mechanisms for the age‐related increase in fatigability during dynamic exercise remain elusive. We tested whether age‐related impairments in muscle oxidative capacity would result in a greater accumulation of fatigue causing metabolites, inorganic phosphate (Pi), hydrogen (H+) and diprotonated phosphate (H2PO4−), in the muscle of old compared to young adults during a dynamic knee extension exercise. The age‐related increase in fatigability (reduction in mechanical power) of the knee extensors was closely associated with a greater accumulation of metabolites within the working muscle but could not be explained by age‐related differences in muscle oxidative capacity. These data suggest that the increased fatigability in old adults during dynamic exercise is primarily determined by age‐related impairments in skeletal muscle bioenergetics that result in a greater accumulation of metabolites. Abstract The present study aimed to determine whether the increased fatigability in old adults during dynamic exercise is associated with age‐related differences in skeletal muscle bioenergetics. Phosphorus nuclear magnetic resonance spectroscopy was used to quantify concentrations of high‐energy phosphates and pH in the knee extensors of seven young (22.7 ± 1.2 years; six women) and eight old adults (76.4 ± 6.0 years; seven women). Muscle oxidative capacity was measured from the phosphocreatine (PCr) recovery kinetics following a 24 s maximal voluntary isometric contraction. The fatiguing exercise consisted of 120 maximal velocity contractions (one contraction per 2 s) against a load equivalent to 20% of the maximal voluntary isometric contraction. The PCr recovery kinetics did not differ between young and old adults (0.023 ± 0.007 s−1 vs. 0.019 ± 0.004 s−1, respectively). Fatigability (reductions in mechanical power) of the knee extensors was ∼1.8‐fold greater with age and was accompanied by a greater decrease in pH (young = 6.73 ± 0.09, old = 6.61 ± 0.04) and increases in concentrations of inorganic phosphate, [Pi], (young = 22.7 ± 4.8 mm, old = 32.3 ± 3.6 mm) and diprotonated phosphate, [H2PO4−], (young = 11.7 ± 3.6 mm, old = 18.6 ± 2.1 mm) at the end of the exercise in old compared to young adults. The age‐related increase in power loss during the fatiguing exercise was strongly associated with intracellular pH (r = –0.837), [Pi] (r = 0.917) and [H2PO4−] (r = 0.930) at the end of the exercise. These data suggest that the age‐related increase in fatigability during dynamic exercise has a bioenergetic basis and is explained by an increased accumulation of metabolites within the muscle.

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“…; Homma et al . ), may play a more prominent role in altering muscle oxidative capacity rather than ageing per se (Kent & Fitzgerald, ).…”

Section: Discussionmentioning

confidence: 99%

Section: Is a Reduced Muscle Oxidative Capacity An Obligatory Consequmentioning

confidence: 99%

Bioenergetic basis for the increased fatigability with ageing

Sundberg

Prost

Fitts

et al. 2019

The Journal of Physiology

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“…In isometric conditions, strength decline is calculated as the ratio between the initial and the final strength during sustained or repetitive contractions, or the slope of the strength decline (e.g., Borji, Sahli, Zarrouk, Zghal, & Rebai, 2013;Homma et al, 2015;Mehta & Agnew, 2012;Rantanen et al, 2000). Other authors reported a statistical comparison of the maximal strength, assessed before and after a specific task (e.g., (Delextrat, Piquet, Matthews, & Cohen, 2018;Severijns, Lemmens, Thoelen, & Feys, 2016).…”

Section: Quantification Of Performance Fatigabilitymentioning

confidence: 99%

Evaluation of performance fatigability through surface EMG in health and muscle disease: state of the art

Beretta-Piccoli

Cescon

D’Antona

2020

Arab Journal of Basic and Applied Sciences

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In literature, it is commonly reported that the progress of performance fatigability may be indirectly assessed through the changes in the features of the surface electromyogram (sEMG) signal. In particular, during isometric constant force contractions, changes in the sEMG signal are caused by several physiological factors, such as a decay in muscle fibers conduction velocity (CV), an increase of the degree of synchronization between the firing times of simultaneously active motor units (MUs), by the central nervous system, and a reduction of the recruitment threshold and a modulation of MUs firing rate. Amplitude and spectral parameters may be used to characterize the global contributions to performance fatigability, such as MU control properties and fiber membrane properties, or central and peripheral factors, respectively. In addition, being CV a physiological parameter, its estimation is of marked interest to the study of fatigue both in physiological and in presence of neuromuscular diseases.

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Effects of Moderators on Physical Training Programs: A Bayesian Approach

Vetter

Foose²

2017

Journal of Strength and Conditioning Research

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Vetter, RE, Yu, H, and Foose, AK. Effects of moderators on physical training programs: a Bayesian approach. J Strength Cond Res 31(7): 1868-1878, 2017-Creating an optimal physical training program is an important focus in sport and exercise research. The purpose of this research was to examine how different moderators (age, ability level, training weeks, training frequencies, and intensity) impacted the physiological outcomes of specific exercise training programs (muscular strength, speed, power, and cardiorespiratory) using the Bayesian method. A Bayesian approach uses flexible frameworks to determine the pattern of outcomes. This Bayesian analysis combined data generated by 34 previous studies from 1984 to 2015 to improve estimates of effects; these studies rendered 312 cases. The analyses for age were strong in cardiorespiratory and speed but less in power and muscular strength. Ability level was not a predictor of outcomes in each of the 4 areas. Training weeks contributed to power and cardiorespiratory, but not for speed, whereas for strength the effect size (ES) increased only up to the 16th week. Training frequency was a nonsignificant predictor of ES; most of the included studies within this analysis used only training frequencies of 2 or 3 days. Training intensity clearly contributed to the ES. The pattern of influence for intensity level in strength was greatest between 55 and 80%, in power it increased at 65% and continued in a positive linear pattern, in cardiorespiratory it increased up to 65% and then plateaued, and for speed no inferences could be made.

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Once-weekly muscle endurance and strength training prevents deterioration of muscle oxidative function and attenuates the degree of strength decline during 3-week forearm immobilization

Cited by 4 publications

References 34 publications

Bioenergetic basis for the increased fatigability with ageing

Bioenergetic basis for the increased fatigability with ageing

Evaluation of performance fatigability through surface EMG in health and muscle disease: state of the art

Effects of Moderators on Physical Training Programs: A Bayesian Approach

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