Assessment of inter-atrial, inter-ventricular, and atrio-ventricular interactions in tetralogy of Fallot patients after surgical correction. Insights from two-dimensional speckle tracking and three-dimensional echocardiography

Rahman, Mohamed Abdel; Raedle-Hurst, Tanja; Rentzsch, Axel; Schäfers, Hans‐Joachim; Abdul‐Khaliq, Hashim

doi:10.1017/s1047951114002108

Cited by 20 publications

(8 citation statements)

References 24 publications

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“…The clinical relevance of impaired atrial function in heart failure development is increasingly recognized [6] . Right atrial (RA) function has been studied in some congenital heart disease (CHD) [7] , [8] using echocardiography and CMR [9] . Both echocardiography and CMR-FT are equally able to discriminate left and right atrial phasic performance based on strain (ε) and strain rate (SR) imaging [10] , [11] , [12] .…”

Section: Introductionmentioning

confidence: 99%

Atrio-ventricular deformation and heart failure in Ebstein's Anomaly — A cardiovascular magnetic resonance study

Steinmetz

Broder

Hösch

et al. 2018

International Journal of Cardiology

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PurposeWe aimed to quantify atrial and ventricular myocardial deformation in Ebstein's Anomaly (EA) in a case-control study with cardiovascular magnetic resonance (CMR) feature tracking and to correlate changes in cardiac performance with the severity of disease and clinical heart failure parameters.Materials and methodsAtrial and ventricular deformation was measured using CMR feature tracking in 30 EA and 20 healthy control subjects. Atrial performance was characterized using longitudinal strain and strain rate parameters for reservoir function, conduit function and booster pump function. Ventricular performance was characterized using RV and LV global longitudinal strain (εl) and LV circumferential and radial strain (εc and εr). Volumetric measurements for the ventricles including the Total Right/Left-Volume-Index (R/L-Volume-Index) and heart failure markers (BNP, NYHA class) were also quantified.ResultsEA patients showed significantly impaired right atrial performance, which correlated with heart failure markers (NYHA, BNP, R/L-Volume-Index). LA function in EA patients was also impaired with atrial contractile function correlating with NYHA class. EA patients exhibited impaired RV myocardial deformation, also with a significant correlation with heart failure markers.ConclusionCMR feature tracking can be used to quantify ventricular and atrial function in a complex cardiac malformation such as EA. EA is characterized by impaired quantitative right heart atrio-ventricular deformation, which is associated with heart failure severity. While LV function remains preserved, there is also significant impairment of LA function. These quantitative performance parameters may represent early markers of cardiac deterioration of potential value in the clinical management of EA.

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Section: Introductionmentioning

confidence: 99%

Atrio-ventricular deformation and heart failure in Ebstein's Anomaly — A cardiovascular magnetic resonance study

Steinmetz

Broder

Hösch

et al. 2018

International Journal of Cardiology

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“…Three-dimensional (3D) echocardiography and 3D derived speckle tracking echocardiography (STE) are novel, reliable techniques for the evaluation of left ventricular (LV) left atrial (LA) performance [ 10 – 14 ]. These techniques are able to detect latent global and regional myocardial dysfunction, which cannot be detected by the conventional echocardiography methods.…”

Section: Introductionmentioning

confidence: 99%

Left Ventricular Systolic Dysfunction in Asymptomatic Marfan Syndrome Patients Is Related to the Severity of Gene Mutation: Insights from the Novel Three Dimensional Speckle Tracking Echocardiography

et al. 2015

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BackgroundIn asymptomatic Marfan syndrome (MFS) patients we evaluated the relationship between the types of fibrillin-1 (FBN1) gene mutation and possible altered left ventricular (LV) function as assessed by three-dimensional speckle tracking echocardiography (3D-STE).Methods and ResultsForty-five MFS patients (mean age 24±15 years) and 40 age-matched healthy controls were studied. Genetic evaluation for the FBN1 gene was carried on 32 MFS patients. Gene mutation (n = 15, 47%) was classified as mild when the mutation resulted in nearly normally functioning protein, while mutations resulting in abnormally function protein were considered to be severe (n = 17, 53%). All patients and controls underwent 3D-STE for evaluation of LV function by an echocardiographer blinded to the results of the genetic testing. Compared to controls, MFS patients had significantly lower 3D-STE derived LV ejection fraction (EF, 57.43±7.51 vs. 62.69±4.76%, p = 0.0001), global LV longitudinal strain (LS, 14.85±2.89 vs. 17.90±2.01%, p = 0.0001), global LV circumferential strain (CS, 13.93±2.81 vs. 16.82±2.17%, p = 0.0001) and global LV area strain (AS, 25.76±4.43 vs. 30.51±2.61%, p = 0.0001). Apart from the global LV LS all these parameters were significantly lower in patients with severe gene mutation than in those with mild mutation (p<0.05). In the multivariate linear regression analysis only the type of mutation had a significant influence on the 3D-STE derived LVEF (p = 0.017), global CS (p = 0.005) and global AS (p = 0.03).ConclusionsIn asymptomatic MFS patients latent LV dysfunction can be detected using 3D STE. The LV dysfunction is mainly related to the severity of gene mutation, suggesting possible primary cardiomyopathy in MFS patients.

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“…Others have evaluated echocardiographic parameters of the right ventricle and their agreement with volumes and function estimated by MRI . There is an increasing interest in functional assessment including strain imaging that may add complimentary information and reveal subclinical disease.…”

Section: Resultsmentioning

confidence: 99%

“…Echocardiographic findings may help decide which patients would require MRI . Echocardiographic analysis of atrial and ventricular function may provide additive information . There are no specific pediatric guidelines for PR classification, and there is no consensus regarding management of children with PR .…”

Section: Resultsmentioning

confidence: 99%

“…67 Echocardiographic analysis of atrial and ventricular function may provide additive information. [85][86][87] There are no specific pediatric guidelines for PR classification, and there is no consensus regarding management of children with PR. 58,67 Yearly echocardiographic follow-up is generally recommended for children with PR after tetralogy of Fallot repair.…”

Section: Summary Of Evidences and Implications For The Decision-makingmentioning

confidence: 99%

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Echocardiographic assessment of pediatric semilunar valve disease

et al. 2017

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We reviewed echocardiography literature for the assessment and management of semilunar valve disease in children. A search was performed within the National Library of Medicine using the keywords aortic stenosis (AS), aortic regurgitation, pulmonary stenosis (PS), and pulmonary regurgitation in children. The search was further refined adding the keywords-pediatric, neonates, echocardiographic definition, classification, evaluation. Thirty-eight studies were included. For stenotic lesions, there were sufficient consistencies between Doppler and invasive gradients (especially for PS), while other quantitative parameters used in adults showed significant limitations when applied to children. Heterogeneities remain in the range of Doppler measurements utilized to define mild vs moderate vs severe AS/PS, and to guide management. There is sufficient consensus regarding indications for interventions. In regurgitant lesions, there is weak evidence supporting the use of quantitative or semiquantitative parameters after correction for body surface area; clear indications for intervention are lacking. Because adult echocardiographic recommendations cannot be simply translated to the pediatric age, more specific pediatric guidelines and standards for the assessment of semilunar valve disease are needed.

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Assessment of inter-atrial, inter-ventricular, and atrio-ventricular interactions in tetralogy of Fallot patients after surgical correction. Insights from two-dimensional speckle tracking and three-dimensional echocardiography

Cited by 20 publications

References 24 publications

Atrio-ventricular deformation and heart failure in Ebstein's Anomaly — A cardiovascular magnetic resonance study

Atrio-ventricular deformation and heart failure in Ebstein's Anomaly — A cardiovascular magnetic resonance study

Left Ventricular Systolic Dysfunction in Asymptomatic Marfan Syndrome Patients Is Related to the Severity of Gene Mutation: Insights from the Novel Three Dimensional Speckle Tracking Echocardiography

Echocardiographic assessment of pediatric semilunar valve disease

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