2014
DOI: 10.1534/genetics.114.171660
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Epigenetic Control of Learning and Memory inDrosophilaby Tip60 HAT Action

Abstract: Disruption of epigenetic gene control mechanisms in the brain causes significant cognitive impairment that is a debilitating hallmark of most neurodegenerative disorders, including Alzheimer's disease (AD). Histone acetylation is one of the best characterized of these epigenetic mechanisms that is critical for regulating learning-and memory-associated gene expression profiles, yet the specific histone acetyltransferases (HATs) that mediate these effects have yet to be fully characterized. Here, we investigate … Show more

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Cited by 55 publications
(59 citation statements)
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“…In Xu et al (2014), the authors investigate whether epigenetic modifications can affect memory-mediated behaviors. "Epigenetics" broadly refers to information in the genome that is not coded by the DNA but refers to certain genomic states and how these states can be influenced by the environment.…”
Section: Histone Modificationmentioning
confidence: 99%
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“…In Xu et al (2014), the authors investigate whether epigenetic modifications can affect memory-mediated behaviors. "Epigenetics" broadly refers to information in the genome that is not coded by the DNA but refers to certain genomic states and how these states can be influenced by the environment.…”
Section: Histone Modificationmentioning
confidence: 99%
“…There are three main families of nuclear HATs (Hodawadekar and Marmorstein 2007;Bannister and Kouzarides 2011). The Tip60 protein investigated in Xu et al (2014) is a member of the MYST family, named for the initial members MOX, Ybf2/Sas3, Sas2, and Tip60. The human Tip60 complex is thought to be involved in DNAdamage responses (Grant 2001).…”
Section: Histone Modificationmentioning
confidence: 99%
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