Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial

doi:10.4081/or.2014.5405

Cited by 79 publications

(95 citation statements)

References 27 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nine RCTs were included in the results, 15,16,[21][22][23][33][34][35]38 3 of which were double blinded ( Table 2). Hyaluronic acid was used for the control groups in 7 RCTs, saline was used in 1 study, and an exercise program was used in another.…”

Section: Randomized Controlled Trialsmentioning

confidence: 99%

“…Other WOMAC and SF-36 (Short Form-36) parameters improved only in the PRP group. Another interesting RCT by Raeissadat et al 16 compared intraarticular PRP injections and a prescribed exercise program with a prescribed exercise program alone. After 6 months, the mean changes of total WOMAC, physical component summery, and mental component summery of SF-36 in the PRP group showed better improvement than the control group (P < 0.05).…”

Section: Randomized Controlled Trialsmentioning

confidence: 99%

See 1 more Smart Citation

PRP for Degenerative Cartilage Disease: A Systematic Review of Clinical Studies

et al. 2016

View full text Add to dashboard Cite

Objective: To explore the utilization of platelet-rich plasma (PRP) for degenerative cartilage processes and evaluate whether there is sufficient evidence to better define its potential effects. Design: Systematic literature reviews were conducted in PubMed/MEDLINE and Cochrane electronic databases till May 2015, using the keywords "platelet-rich plasma OR PRP OR autologous conditioned plasma OR ACP AND cartilage OR chondrocyte OR chondrogenesis OR osteoarthritis (OA) OR arthritis." Results: The final result yielded 29 articles. Twenty-six studies examined PRP administration for knee OA and 3 involved PRP administration for hip OA. The results included 9 prospective randomized controlled trials (RCTs) (8 knee and 1 hip), 4 prospective comparative studies, 14 case series, and 2 retrospective comparative studies. Hyaluronic acid (HA) was used as a control in 11 studies (7 RCTs, 2 prospective comparative studies, and 2 retrospective cohort). Overall, all RCTs reported on improved symptoms compared to baseline scores. Only 2 RCTs-one for knee and one for hip-did not report significant superiority of PRP compared to the control group (HA). Nine out of 11 HA controlled studies showed significant better results in the PRP groups. A trend toward better results for PRP injections in patients with early knee OA and young age was observed; however, lack of uniformity was evident in terms of indications, inclusion criteria, and pathology definitions in the different studies. Conclusion: Current clinical evidence supports the benefit in PRP treatment for knee and hip OA, proven to temporarily relieve pain and improve function of the involved joint with superior results compared with several alternative treatments. Further research to establish the optimal preparation protocol and characteristics of PRP injections for OA is needed.

show abstract

Section: Randomized Controlled Trialsmentioning

confidence: 99%

Section: Randomized Controlled Trialsmentioning

confidence: 99%

PRP for Degenerative Cartilage Disease: A Systematic Review of Clinical Studies

et al. 2016

View full text Add to dashboard Cite

show abstract

“…There is experimental evidence for positive effects of PRP in the context of soft tissue healing, ligament and bone regeneration, and inflammation reduction [7][8][9][10]. In another study on Egyptian patients with lateral epicondylitis and with plantar fasciitis, PRP was found promising and effective in both [11].…”

Section: Introductionmentioning

confidence: 99%

Effectiveness of the intra-articular injection of platelet rich plasma in the treatment of patients with primary knee osteoarthritis

Hassan

El-Shafey

Ahmed

et al. 2015

The Egyptian Rheumatologist

View full text Add to dashboard Cite

Osteoarthritis (OA) is the most prevalent form of arthritis in the world. Aim of the work: To evaluate the effect of 6-monthly intra-articular injection of platelet rich plasma (PRP) on the functional status of knee joint measured by the International Knee Document Committee scale (IKDC), the visual analogue scale for pain (VAS) on the ultrasonographic findings of OA knee. Assessment of its safety as a new line of treatment was taken into consideration.Patients and methods: The study was carried out on 20 patients with mild to moderate primary knee OA. They were injected intra-articularly with 5 ml PRP for each affected joint, at 1 month intervals for 6 injections. Clinical examination, VAS, IKDC score and diagnostic Doppler ultrasonography were performed before and after PRP treatment.Results: After 6 months of PRP, there was a significant improvement in the duration of inactivity stiffness (8.3 ± 2.4 min), VAS score (3.9 ± 1.1) and IKDC score (74.3 ± 10.2) compared to baseline values (18.7 ± 6.5 min, 5.9 ± 1.3 and 40.9 ± 10.4 respectively; p < 0.001). A significant improvement in Doppler activity (p = 0.04) and synovial thickening (p < 0.001) was found after 6 months of PRP. A significant correlation was found between age of patients, body mass index and disease duration with the VAS (r = 0.55, p < 0.001 and r = 0.29, p = 0.03 and r = 0.71, Please cite this article in press as: Hassan AS et al. Effectiveness of the intra-articular injection of platelet rich plasma in the treatment of patients with primary knee osteoarthritis, The Egyptian Rheumatologist (2014), http://dx.) and a negative correlation with the IKDC score (r = À0.32, p = 0.03, r = À0.96, p < 0.001 and r = À0.79, p < 0.001 respectively). Conclusion: Intra-articular injection of PRP is an effective and safe method for treatment of knee OA. Maximal improvement is obtained in patients with young age and short disease duration.

show abstract

“…61 In some in vitro and in vivo studies, antiinflammatory and reparative effects of PRP on cartilage, tendon, and ligament recovery have been shown. [62][63][64] The rationale for the use of Several studies have reported PRP to be clinically safe and effective in reducing pain following intra-articular injection of PRP up to 12 months following treatment. [66][67][68][69] Positive outcomes are mostly found more commonly in younger patients with Milles severe knee OA.…”

Section: Platelet-rich Plasma (Prp)mentioning

confidence: 99%

“…61 In some in vitro and in vivo studies, antiinflammatory and reparative effects of PRP on cartilage, tendon, and ligament recovery have been shown. [62][63][64] The rationale for the use of PRP is to stimulate the natural healing cascade and tissue regeneration by release of platelet-derived factors directly at the site of treatment. …”

mentioning

confidence: 99%

Emerging Potential of Cell Based Therapies for Articular Cartilage Repair and Regeneration

Venkatesh¹

2017

ATROA

View full text Add to dashboard Cite

Abbreviations: ACI, autologous chondrocyte implantation;MSCs, mesenchymal stem cells; PRP, platelet-rich plasma; BMC, autologous bone marrow concentrate; TKR, total knee replacement IntroductionOsteoarthritis is a form of arthritis described as a degenerative joint disease that results from the breakdown of articular cartilage and underlying subchondral bone.1,2 Cartilage is firm, rubbery, protein substance that serves as a "cushion" between the bones, providing a smooth, gliding surface for joint motion. As the cartilage breaks down, it causes pain, swelling, stiffness and problems moving the joint.3 Therefore, Osteoarthritis is a chronic disease and a major cause of disability, characterized by irreversible cartilage degeneration, bony changes of the joints, deterioration of tendons and ligaments, and inflammation of the synoviumas shown in Figure 1. 4 An initial degeneration, known as the 'pre-OA' state may be reversible spontaneously or through preventive measures, however, if not stopped, the disease progresses to later stages which results in loss of articular cartilage surface integrity, break down of bone and osteophyte formation.3,5 OA can affect any joint, but it most often occurs in the knee, hip, lower back and neck, small joints in the finger and base of the big toe ( Figure 2). 6,7Osteoarthritis of the knee is the most common chronic condition affecting all races, gender and ages, but known to be the most common in elderly and obese people. 8,9 The knee acts as a conduit for transferring body weight essential for normal human mobility and the menisci is known to maintain the normal function of the knee, distribute load, lubricate the joint and provide joint stability. Injury to the meniscus from ageing cartilage, repetitive activity or trauma results in pain, limits movement and can accelerate the occurrence and development of OA. In general, partial or complete meniscectomy causes OA of the knee. 8,10,11 While the prevalence of OA increases with age and causes significant decline in the quality of life of individuals above the age of 65, there is increasing evidence of OA in younger population as a result of prior injuries such as anterior cruciate ligament tear or meniscal tears. 8,12,13 Figure 1 Comparison schematic between healthy knee and arthritic knee.Osteoarthritis affects about 237 million of the population, of which an estimated 9 million people alone in United States suffer from symptomatic knee osteoarthritis and it is predicted that an additional 19 million people will be affected by arthritis by 2020. 14-17The incidence of chondral defects is frequent with sporting injuries, and in elderly patients specifically 10% of population over the age of 55 years have troublesome knee pain, and of those, 25% are severely disabled.18 Depending on disease severity, management ranges from conservative treatment to surgical intervention, including total knee replacement. 14,19 In recent years the number and cost of TKR has increased dramatically between 2001 and 2012 from 305,000 to 610,000 procedu...

show abstract

Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial

Cited by 79 publications

References 27 publications

PRP for Degenerative Cartilage Disease: A Systematic Review of Clinical Studies

PRP for Degenerative Cartilage Disease: A Systematic Review of Clinical Studies

Effectiveness of the intra-articular injection of platelet rich plasma in the treatment of patients with primary knee osteoarthritis

Emerging Potential of Cell Based Therapies for Articular Cartilage Repair and Regeneration

Contact Info

Product

Resources

About