Ectopic recurrence of craniopharyngioma: Reporting three new cases

Yang, Yang; Shrestha, Devendra; Shi, Xiaoyan; Zhou, Zhongqing; Qi, Xueling; Qian, Hai

doi:10.3109/02688697.2014.967751

Cited by 10 publications

(3 citation statements)

References 2 publications

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“…The involvement of the third ventricle may derive from craniopharyngioma's development along the migration of the Rathke's pouch close to the infundibulum and attached to the third ventricle floor, or from residual squamous epithelium of the stomodeum embedded within the ventricular system at early stages of pituitary gland development (24). Aggressive growth may also lead to tumor's invasion into the lateral ventricles through the Monro's foramina, with only 12 cases reported in the current literature (25)(26)(27)(28)(29). A total of 4 cases of fourth ventricle CP-Vs were described, defined as ectopic craniopharyngiomas invading the cerebellopontine angle (11,(18)(19)(20), with some authors suggesting a potential relationship with Gardner's syndrome (30).…”

Section: Discussionmentioning

confidence: 99%

Craniopharyngiomas Invading the Ventricular System: A Systematic Review

et al. 2022

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Background/Aim: Craniopharyngiomas involving the ventricular system are rare but pose significant surgical challenges. We systematically reviewed the literature on craniopharyngiomas invading the ventricles (CP-V). Materials and Methods: PubMed, EMBASE, Scopus, Web of Science, and Cochrane were searched to include studies reporting clinical data of patients with CP-Vs. Clinico-radiological features, management, and treatment outcomes were analyzed. Results: We included 73 studies encompassing 407 patients. Patients were mostly male (61.5%), presenting with headache (57.9%) and/or endocrine disorders (52.1%). CP-Vs mostly involved the third ventricle (96.3%), followed by the lateral ventricles (2.9%), and the fourth ventricle (1%). Tumors had cystic components in 59% of cases and were mostly adamantinomatous (70.8%). Open resection was performed in 232 cases (57%), mostly with trans-lamina terminalis (36.6%) and trans-callosal (31.9%) approaches. Endoscopic resection was performed in 169 cases (41.5%), mostly with trans-sphenoidal (74.6%) and transventricular (24.9%) approaches. Gross-total tumor resection was obtained in most cases (62.9%). Adjuvant radiotherapy was delivered in 22.8% cases. A total of 178 patients experienced persistent complications, mostly including diabetes insipidus (47.1%) and panhypopituitarism (12.7%), not significantly different after open versus endoscopic resection (p=0.117). Symptom improvement was obtained in 88% of cases. CP-Vs recurrences were reported in 94 patients (23.1%), with median progression-free survival of 13.5 months (range=0.5-252.0 months). Fifty-nine patients died (14.5%), with median overall survival of 32.0 months (range=0.5-252.0 months), significantly longer after endoscopic resection than open resection (p=0.019). Conclusion: CP-Vs are uncommon and challenging entities. Surgical resection is feasible, but patient-tailored selection of open/endoscopic approaches is necessary to achieve optimal outcomes and minimize complication risks.Craniopharyngiomas comprise a heterogeneous group of benign neoplasms accounting for 1.2-4.6% of all intracranial tumors and showing two peaks of age incidence, in children or young 4189

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Section: Discussionmentioning

confidence: 99%

Craniopharyngiomas Invading the Ventricular System: A Systematic Review

et al. 2022

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“…All reported cases underwent surgery. 1,3,[5][6][7] Ectopic recurrence can occur over a wide range of time after resection (1 month-26 years), with a median of 4 years. Equal prevalence was seen in male and female patients (43% female, 57% male).…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Recurrence of Craniopharyngioma at Ectopic Site after Surgical Resection of Primary Tumor

Dey

Rao

Sinha

et al. 2018

IJNS

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Ectopic recurrence of craniopharyngiomas after surgical resection of primary lesion is extremely rare. In this article, the authors describe a case of a 12-year-old girl with ectopic recurrence of craniopharyngioma in an extra-axial location in the right frontal region, after an attempt to completely resect the lesion originally located in the sellar region. The patient was investigated radiologically, hormonally, and histopathologic confirmation was sought. During surgery, it is important to take extra care in removing the primary lesion in toto. In case of cystic tumors, it is very important to aspirate cystic fluid completely, before resecting the capsule to avoid rupture or spillage. Long-term clinical and radiologic follow-up is suggested as ectopic recurrence may occur at a very late stage.

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“…Unlike the diverse anatomical classification methods applied to PCP, the cystic nature of ACP facilitates tumor growth in various locations, including the anterior and middle cranial fossae, interpeduncular cisterna, ramus, cerebellar pontine region, and there have even been partial reports of ectopic ACP cases (28)(29)(30)(31). Currently, there exists no pertinent literature on the anatomical classification of ACP.…”

Section: Morphological and Histological Featuresmentioning

confidence: 99%

Advances in the treatment of Adamantinomatous craniopharyngioma: How to balance tumor control and quality of life in the current environment: a narrative review

Chen,

Ai,

Sun

2023

Front. Oncol.

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Adamantinomatous craniopharyngioma (ACP) presents a significant challenge to neurosurgeons despite its benign histology due to its aggressive behavior and unique growth patterns. This narrative review explores the evolving landscape of ACP treatments and their efficacy, highlighting the continuous development in therapeutic approaches in recent years. Traditionally, complete resection was the primary treatment for ACP, but surgical -related morbidity have led to a shift. The invasive nature of the finger-like protrusions in the histological structure results in a higher recurrence rate for ACP compared to papillary craniopharyngioma (PCP), even after complete macroscopic resection. Given this, combining subtotal resection with adjuvant radiotherapy has shown potential for achieving similar tumor control rates and potentially positive endocrine effects. Simultaneously, adjuvant treatments (such as radiotherapy, intracystic treatment, and catheter implantation) following limited surgery offer alternative approaches for sustained disease control while minimizing morbidity and alleviating clinical symptoms. Additionally, advances in understanding the molecular pathways of ACP have paved the way for targeted drugs, showing promise for therapy. There is a diversity of treatment models for ACP, and determining the optimal approach remains a subject of ongoing debate in the present context. In order to achieve a good-term quality of life (QOL), the main goal of the cyst disappearance or reduction of surgical treatment is still the main. Additionally, there should be a greater emphasis on personalized treatment at this particular stage and the consideration of ACP as a potentially chronic neurosurgical condition. This review navigates the evolving landscape of ACP therapies, fostering ongoing discussions in this complex field.

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Ectopic recurrence of craniopharyngioma: Reporting three new cases

Cited by 10 publications

References 2 publications

Craniopharyngiomas Invading the Ventricular System: A Systematic Review

Craniopharyngiomas Invading the Ventricular System: A Systematic Review

A Rare Case of Recurrence of Craniopharyngioma at Ectopic Site after Surgical Resection of Primary Tumor

Advances in the treatment of Adamantinomatous craniopharyngioma: How to balance tumor control and quality of life in the current environment: a narrative review

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