Two new compounds from <i>Ganoderma lucidum</i>

Wang, Xinfang; Yan, Yong‐Ming; Wang, Xinlong; Ma, Xiu-Jing; Fu, Xueyan; Cheng, Yong‐Xian

doi:10.1080/10286020.2014.960858

Cited by 16 publications

(7 citation statements)

References 5 publications

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“…configs. being not assigned [279]. Compounds 576a/576b featuring an interesting polycyclic meroterpenoid skeleton with a glycerol unit were isolated from G. applanatum in 2017 [280].…”

Section: Enantiomers From Phylum Basidiomycotamentioning

confidence: 99%

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Natural Enantiomers: Occurrence, Biogenesis and Biological Properties

Capon

et al. 2022

Molecules

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The knowledge that natural products (NPs) are potent and selective modulators of important biomacromolecules (e.g., DNA and proteins) has inspired some of the world’s most successful pharmaceuticals and agrochemicals. Notwithstanding these successes and despite a growing number of reports on naturally occurring pairs of enantiomers, this area of NP science still remains largely unexplored, consistent with the adage “If you don’t seek, you don’t find”. Statistically, a rapidly growing number of enantiomeric NPs have been reported in the last several years. The current review provides a comprehensive overview of recent records on natural enantiomers, with the aim of advancing awareness and providing a better understanding of the chemical diversity and biogenetic context, as well as the biological properties and therapeutic (drug discovery) potential, of enantiomeric NPs.

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“…configs. being not assigned [279]. Compounds 576a/576b featuring an interesting polycyclic meroterpenoid skeleton with a glycerol unit were isolated from G. applanatum in 2017 [280].…”

Section: Enantiomers From Phylum Basidiomycotamentioning

confidence: 99%

“…configs. of the enantiomers [279]. In 2015, sesquiterpenoids 603a and 604a [288] from the fungus Granulobasidium vellereum were identified as the enantiomers of illidin M (603b) [289] and dihydroilludin (604b) [290], respectively.…”

Section: Enantiomers From Phylum Basidiomycotamentioning

confidence: 99%

Natural Enantiomers: Occurrence, Biogenesis and Biological Properties

Capon

et al. 2022

Molecules

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“…However, all of them didn’t show any inhibitory activities. (±)-Chizhine E and F ( 15 , 19 ) and (±)-lucidulactone ( 16 ) were isolated from G. lucidum and the individual enantiomers of compounds 15 and 19 significantly inhibit monocyte chemotactic protein 1 (MCP-1) and fibronectin production in a dose-dependent manner [ 31 , 36 ]. Fornicin E ( 25 ) obtained from G. capense also was a pair of enantiomers, which showed stronger DPPH scavenging activity than vitamin E (positive control) [ 16 ].…”

Section: Chemical Structures and Bioactivities Of Gmsmentioning

confidence: 99%

Meroterpenoids from Ganoderma Species: A Review of Last Five Years

Peng

Qiu

2018

Nat. Prod. Bioprospect.

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Meroterpenoids are hybrid natural products that partially originate from the terpenoid pathway. Ganoderma meroterpenoids (GMs) are a type of meroterpenoids containing a 1,2,4-trisubstituted phenyl and a polyunsaturated terpenoid part. Over last 5 years, great efforts have been made to conduct phytochemistry research on the genus Ganoderma, which have led to the isolation and identification of a number of GMs. These newly reported GMs showed diverse structures and a wide range of biological activities. This review gives an overview of new GMs from genus Ganoderma and their biological activities and biosynthetic pathway, focusing on the period from 2013 until 2018.Graphical Abstract

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“…We have conducted an extensive and oriented study on meroterpenoids from G. lucidum and found structurally and biologically intriguing meroterpenoids. [8][9][10] Inspired by these previous findings, we have embarked an investigation on G. sinensis, leading to the isolation of (±)-sinensilactam A and biologically important meroterpenoids with a para-hydroxycinnamyl group in the structure [11][12][13]. As a continuous study on G. sinensis, the current investigation resulted in the characterization of five new meroterpenoids, zizhines P−S and U (1−4,7) along with two previously reported meroterpenoids (5 and 6) (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Meroterpenoids from the Fungus Ganoderma sinensis and First Absolute Configuration Clarification of Zizhine H

et al. 2019

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Five new meroterpenoids, zizhines P-S and U (1−4,7), together with two known meroterpenoids (5 and 6) were isolated from Ganoderma sinensis. Their structures including absolute configurations were assigned by using spectroscopic, computational, and chemical methods. Racemics zizhines P and Q were purified by HPLC on chiral phase. Biological evaluation found that 4, 5 and 6 are cytotoxic toward human cancer cells (A549, BGC-823, Kyse30) with IC50 values in the range of 63.43–80.83 μM towards A549, 59.2 ± 2.73 μM and 64.25 ± 0.37 μM towards BGC-823, 76.28 ± 1.93 μM and 85.42 ± 2.82 μM towards Kyse30.

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Two new compounds from Ganoderma lucidum

Abstract: Two pairs of new enantiomers, lucidulactones A and B (1 and 2), and two known compounds were isolated from Ganoderma lucidum. Their structures were determined by means of spectroscopic methods. The chiral HPLC was used to separate the ( - )- and (+)-antipodes of the new compounds.

Cited by 16 publications

References 5 publications

Natural Enantiomers: Occurrence, Biogenesis and Biological Properties

Natural Enantiomers: Occurrence, Biogenesis and Biological Properties

Meroterpenoids from Ganoderma Species: A Review of Last Five Years

Meroterpenoids from the Fungus Ganoderma sinensis and First Absolute Configuration Clarification of Zizhine H

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